Review of experiences with iodized oil in national programmes for control of iodine deficiency disorders

Sankar, Rajan; Pandav, Chandrakant S; Ahmed, F. U.; Rao, P. Amruth; Dwivedi, Manish Kumar; Desai, VK; Karmarkar, M. G.; Nath, L. M.

doi:10.1007/bf02755058

Cited by 9 publications

(2 citation statements)

References 21 publications

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“…It has only been possible to document this parame ter indirectly by a reduction in the prevalence of neonatal hypothyroidism and its adverse effects on the development of the nervous sys tem. This study confirms that iodine supple mentation during the early phase of pregnan cy effectively prevents iodine deficiency in this organ before birth as well as in the neona tal period [4,5,15,18].…”

Section: Discussionsupporting

confidence: 75%

“…It has indeed been shown that the iodine concentration in a mother treated with iodized oil during preg nancy was 4 times higher than that observed in an untreated control group [18]. Further more, it would seem that treatment during early pregnancy (first trimester) gives rise to a higher rate of secretion in milk than when treatment is administered later [5].…”

Section: Discussionmentioning

confidence: 96%

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Secretion in Milk and Transplacental Transfer of Two Iodized Oils, Lipiodol UF® and Oriodol®, in Rabbits

et al. 1997

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Many countries in the world are inhabited by populations suffering from iodine deficiency. These populations are affected by serious diseases directly related to iodine deficiency. Iodized oil (Lipiodol UF^® or Oriodol^®) is routinely used orally or intramuscularly to treat these populations, including pregnant women. The experiments of the present study in gravid or lactating rabbits show that there is transplacental transfer of iodine and secretion of iodine in milk after administration of iodized oil and consequently an accumulation of iodine in the thyroid glands of the mother, the fetus and the neonate. The advantages of treating pregnant women with iodized oil in the populations concerned is thus confirmed. The oral route can be substituted by the intramuscular route.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 96%

Secretion in Milk and Transplacental Transfer of Two Iodized Oils, Lipiodol UF® and Oriodol®, in Rabbits

et al. 1997

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Iodine supplementation for preventing iodine deficiency disorders

Clar¹,

2002

The Cochrane Database of Systematic Reviews (Protocol)

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Iodine supplementation for preventing iodine deficiency disorders in children

Angermayr¹,

Clar²

2004

Cochrane Database of Systematic Reviews

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Despite most of the included studies being of low quality, the results suggest that iodine supplementation, especially iodised oil, is an effective means of decreasing goitre rates and improving iodine status in children. Indications of positive effects on physical and mental development and mortality were seen, although results were not always significant. Adverse effects were generally minor and transient. Insufficient evidence was available on non-oil supplements. High quality controlled studies investigating relevant long term outcome measures are needed to address the question of the best form of iodine supplementation in different population groups and settings.

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Review of experiences with iodized oil in national programmes for control of iodine deficiency disorders

Cited by 9 publications

References 21 publications

Secretion in Milk and Transplacental Transfer of Two Iodized Oils, Lipiodol UF<sup>®</sup> and Oriodol<sup>®</sup>, in Rabbits

Secretion in Milk and Transplacental Transfer of Two Iodized Oils, Lipiodol UF<sup>®</sup> and Oriodol<sup>®</sup>, in Rabbits

Iodine supplementation for preventing iodine deficiency disorders

Iodine supplementation for preventing iodine deficiency disorders in children

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