Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins

Voronkov, Andrey; Gamzeleva, O. Yu.

doi:10.21518/1995-1477-2019-1-2-27-33

Stacionarozameshchayushchie tekhnologii: Ambulatornaya khirurgi

2019

DOI: 10.21518/1995-1477-2019-1-2-27-33

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Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins

Andrey Voronkov

O. Yu. Gamzeleva

Abstract: Информация об авторах Воронков Андрей Владиславовичд.м.н., доцент, заведующий кафедрой фармакологии с курсом клинической фармакологии Пятигорского медикофармацевтического институтафилиала государственного бюджетного образовательного учреждения высшего профессионального образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации;

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Cited by 5 publications

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Improving the Efficiency of Betulin-Containing Food Ingredients From Silver Birch (Betula Pendula Roth.) in Food Systems

Averyanova¹,

Shkolnikova²

2022

JCPRM

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The demand for food micro-ingredients in modern technologies is quite high, however, the production of preservatives, antioxidants and other food additives in the Russian Federation is extremely limited, which has created a high import dependence unacceptable in modern conditions. Raw sources of preservatives include birch bark containing 10–40% betulin – a triterpenoid with high biological activity and preservative / antioxidant properties. However, the weak solubility of betulin in an aqueous medium hinders its use in food products. In this work, a study was carried out to develop a method for obtaining a micronized form of betulin for use as a food ingredient in food products of various compositions. The following values of parameters and modes of ultrasonic micronization of water suspensions of betulin were established: frequency – 50±5 kHz, acoustic power – 50 W, temperature, about 50 °С, duration 60 min. It is shown that the micronization of betulin under ultrasonic exposure indicates an increase in the uniformity of its aqueous suspension of betulin, the alignment of the size and shape of particles, which minimizes the influence of barrier factors during the assimilation of a food additive and determines its effectiveness and bioavailability in the composition of both water-based and fat-based foods.

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Improving the Efficiency of Betulin-Containing Food Ingredients From Silver Birch (Betula Pendula Roth.) in Food Systems

Averyanova¹,

Shkolnikova²

2022

JCPRM

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Phleboprotectors Based on Flavonoids: Dosage Forms, Biopharmaceutical Characteristics, Technological Features

Степанова

Remezova

Shevchenko

et al. 2021

Farm. farmakol. (Pâtigorsk)

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Micronized purified flavonoid fraction (MPFF) is the original phlebotropic drug. Its marketed form (Detralex®) consists of 90% diosmin and 10% of other flavonoids. Calculated as hesperidin, it is the most widely used drug today. Diosmin and hesperidin, which are parts of the majority of venoactive drugs, are sparingly water-soluble compounds, and this feature can effect on their clinical efficacy. One of the ways to increase the solubility of these compounds leading to an increase in bioavailability, is the micronization of the active ingredients.The aim of the investigation is a comparative determination of the dynamics and dissolution efficiency of the drugs containing bioflavonoid fractions in the dissolution test, as well as the analysis of the micronization degree and its impact on technology and biopharmaceutical parameters.Materials and methods. A biopharmaceutical release profile was determined using HPLC. Disintegration, characteristics of the shape and size of the tablets’ particles were determined according to the methods of the State Pharmacopoeia of the XIV-th edition.Results. The objects created with the use of diosmin and hesperidin, have been considered in detail. The role of technological solutions in relation to the corresponding dosage forms is notified. Detailed biopharmaceutical characteristics have been established with a choice of HPLC-based release control methodology. All the drugs in this group have a low water solubility leading to the maximum bioavailability for Detralex® which is about 1.26%; and no more than 0.2% for other analyzed models.Conclusion. Detralex® dominates among the analyzed objects (tablets) in terms of the release rate. With regard to the overall quantitative indicators of release, the actual numbers are quite low, which is associated with the poor water solubility of the active substances.

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A combination of bioflavonoid, oral thrombolytic and anticoagulant in the treatment of thrombophlebitis of varicose veins in outpatient surgical practice

Krivoshchekov,

Poseryaev,

Khoroshilov

et al. 2024

Ambulatornaya khirurgiya

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Introduction. Comparability of the outcomes of treatment of patients with thrombophlebitis of varicose veins using surgical intervention and medical therapy, a wide range of drugs have become the basis for conducting this study.Aim. To evaluate the effectiveness of the use of micronized purified flavonoid fraction in comparison with the isolated use of diosmin in patients with superficial varicothrombophlebitis in outpatient surgical practice.Materials and methods. From 2021 to 2022, a prospective study of the treatment results of 82 patients (from 42 to 68 years old, average age: 54.3 ± 12.34 years) with a diagnosis of superficial vein thrombophlebitis was conducted. To relieve inflammation as soon as possible and accelerate recanalization, a direct oral thrombolytic was prescribed. The patients were divided into two groups. The main group (44 patients) took a drug consisting of diosmin 900 mg (90%) and flavonoids in terms of hesperidin 100 mg (10%). In the comparison group (38 people), unmicronized diosmin was taken at a dosage of 600 mg.Results and discussion. Thrombophlebitis of superficial veins was more often localized in the basin of the great saphenous vein (47 patients (57.3%)). On the 30th day after the start of treatment, there was no progression of the thrombotic process. In the main and control groups, the symptoms of thrombophlebitis (a feeling of tightness under the skin and local soreness in the area of varicose veins) were eliminated in 34 (77.3%) of the main group and 22 (57.9%) patients of the comparison group. There was a decrease in the signs of chronic venous insufficiency from 73.7 to 36.4%, as well as a statistically large proportion of patients with complete or partial recanalization (70.5 vs 44.5% in the control group).Conclusion. The results of the study show that the micronized purified flavonoid fraction has advantages over non-micronized diosmin in reducing the severity of symptoms, significantly reducing the signs of chronic venous insufficiency and improving quality.

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Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins

Cited by 5 publications

References 19 publications

Improving the Efficiency of Betulin-Containing Food Ingredients From Silver Birch (Betula Pendula Roth.) in Food Systems

Improving the Efficiency of Betulin-Containing Food Ingredients From Silver Birch (Betula Pendula Roth.) in Food Systems

Phleboprotectors Based on Flavonoids: Dosage Forms, Biopharmaceutical Characteristics, Technological Features

A combination of bioflavonoid, oral thrombolytic and anticoagulant in the treatment of thrombophlebitis of varicose veins in outpatient surgical practice

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