Review on heavy ion radiotherapy facilities and related ion sources (invited)

Kitagawa, A.; Fujita, Takeshi; Muramatsu, M.; Biri, S.; Drentje, A.G.

doi:10.1063/1.3268510

Cited by 41 publications

(25 citation statements)

References 37 publications

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“…Although PLD repair has been studied extensively for decades, the molecular and biochemical events mediating its expression remain incompletely understood, particularly for cells exposed to high-LET radiations. Such studies would have important implications for radiotherapy, because α particles and high-charge/high-energy particles, another type of high-LET radiation, are being used increasingly in cancer treatment (60, 61). Understanding the biological effects that occur shortly or a few hours after exposure to such particles may help potentiate their therapeutic efficacy and clarify the associated risks to irradiated, or bystander, normal tissues adjacent to the tumor target.…”

Section: Discussionmentioning

confidence: 99%

The Role of Gap Junction Communication and Oxidative Stress in the Propagation of Toxic Effects among High-Dose α-Particle-Irradiated Human Cells

et al. 2011

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We investigated the roles of gap junction communication and oxidative stress in modulating potentially lethal damage repair in human fibroblast cultures exposed to doses of α particles or γ rays that targeted all cells in the cultures. As expected, α particles were more effective than γ rays at inducing cell killing; further, holding γ-irradiated cells in the confluent state for several hours after irradiation promoted increased survival and decreased chromosomal damage. However, maintaining α-particle-irradiated cells in the confluent state for various times prior to subculture resulted in increased rather than decreased lethality and was associated with persistent DNA damage and increased protein oxidation and lipid peroxidation. Inhibiting gap junction communication with 18-α-glycyrrhetinic acid or by knockdown of connexin43, a constitutive protein of junctional channels in these cells, protected against the toxic effects in α-particle-irradiated cell cultures during confluent holding. Upregulation of antioxidant defense by ectopic overexpression of glutathione peroxidase protected against cell killing by α particles when cells were analyzed shortly after exposure. However, it did not attenuate the decrease in survival during confluent holding. Together, these findings indicate that the damaging effect of α particles results in oxidative stress, and the toxic effects in the hours after irradiation are amplified by intercellular communication, but the communicated molecule(s) is unlikely to be a substrate of glutathione peroxidase.

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Section: Discussionmentioning

confidence: 99%

The Role of Gap Junction Communication and Oxidative Stress in the Propagation of Toxic Effects among High-Dose α-Particle-Irradiated Human Cells

et al. 2011

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“…2 Presently, there are eight facilities in operation, and six facilities are under construction. There are many other constructions under planning or budget requests.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, heavy-ion beams are utilized for radiotherapy. 2 In the case of carbon ions, an energy of 430 MeV/u is necessary to realize a range of 30 cm in water. The relative biological effectiveness (RBE) is defined as the ratio of a biological effect by gamma rays to that by other radiation.…”

Section: Introductionmentioning

confidence: 99%

Recent developments of ion sources for life-science studies at the Heavy Ion Medical Accelerator in Chiba (invited)

Kitagawa¹,

Drentje²,

Fujita³

et al. 2015

Review of Scientific Instruments

Self Cite

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With about 1000-h of relativistic high-energy ion beams provided by Heavy Ion Medical Accelerator in Chiba, about 70 users are performing various biology experiments every year. A rich variety of ion species from hydrogen to xenon ions with a dose rate of several Gy/min is available. Carbon, iron, silicon, helium, neon, argon, hydrogen, and oxygen ions were utilized between 2012 and 2014. Presently, three electron cyclotron resonance ion sources (ECRISs) and one Penning ion source are available. Especially, the two frequency heating techniques have improved the performance of an 18 GHz ECRIS. The results have satisfied most requirements for life-science studies. In addition, this improved performance has realized a feasible solution for similar biology experiments with a hospital-specified accelerator complex.

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“…[22][23][24] At present, there are only nine facilities for CIRT worldwide, and only three have more than three years of experience: NIRS in Japan since 1994; GSI (Gesellschaft für Schwerionenforschung) in Germany since 1997; and HIBMC (Hyogo Ion Beam Medical Center) in Japan since 2002. 25 However, we anticipate that it will become more widely available in the future.…”

Section: -13mentioning

confidence: 99%

Total spondylectomy following carbon ion radiotherapy to treat chordoma of the mobile spine

Matsumoto

Imagama

Ito

et al. 2013

The Bone & Joint Journal

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The main form of treatment of a chordoma of the mobile spine is total en bloc spondylectomy (TES), but the clinical results are not satisfactory. Stand-alone carbon ion radiotherapy (CIRT) for bone and soft-tissue sarcomas has recently been reported to have a high rate of local control with a low rate of local recurrence.We report two patients who underwent TES after CIRT for treating a chordoma in the lumbar spine with good medium-term outcomes. At operation, there remained histological evidence of viable tumour cells in both cases. After the combination use of TES following CIRT, neither patient showed signs of recurrence at the follow-up examination. These two cases suggest that CIRT should be combined with total spondylectomy in the treatment of chordoma of the mobile spine. Chordomas are thought to arise from cellular remnants of the notochord; they account for 1% to 4% of all malignant tumours of bone.

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Review on heavy ion radiotherapy facilities and related ion sources (invited)

Cited by 41 publications

References 37 publications

The Role of Gap Junction Communication and Oxidative Stress in the Propagation of Toxic Effects among High-Dose α-Particle-Irradiated Human Cells

The Role of Gap Junction Communication and Oxidative Stress in the Propagation of Toxic Effects among High-Dose α-Particle-Irradiated Human Cells

Recent developments of ion sources for life-science studies at the Heavy Ion Medical Accelerator in Chiba (invited)

Total spondylectomy following carbon ion radiotherapy to treat chordoma of the mobile spine

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