Aconitum heterophyllum, a medicinal herb commonly used in Ayurveda, which belongs to the Ranunculaceae family and is known to have a number of therapeutic properties. Root tubers of this plant are commonly used in pediatric medicine for fever management. It has also been used as an antipyretic, antibacterial, anthelmintic, antitussive, anti-inflammatory, and antidiarrheal agent. The root tubers are rich sources of diterpene alkaloids, which may be one of the reasons for the medicinal properties. Required data on this plant were obtained from electronic sources (Google scholar, PubMed, Scopus, Web of Science), several classical textbooks on Ayurveda, and ethnopharmacology. This review article covers all the relevant information on its pharmacological and phytochemical aspects. In this study, we have critically reviewed recent advancements of Aconitum heterophyllum in order to validate its usage as a multipurpose therapeutic agent.