Review on Role of Natural Αlpha-Glucosidase Inhibitors for Management of Diabetes Mellitus

Naquvi, Kamran Javed; Ahamad, Javed; Mir, Showkat R.; Ali, Mohd.; Shuaib, Mohd

doi:10.7439/ijbr.v2i6.121

Cited by 28 publications

(11 citation statements)

References 13 publications

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“…Rhazya stricta is claimed to contain various medicinal properties including antihyperglycemic effects like some other members of Apocynaceae family e.g., Telosma procumbens Merr., Vinca rosea L., Picralima nitida [ 47 ] . Root extracts of the plant inhibited α-glucosidase enzyme that can lead to better glycemic control through a reduction in disaccharide hydrolysis [ 48 ]. The inhibition of the DPP-IV enzyme is another strategy to keep incretin hormones available in the blood for insulin-dependent disposal of glucose from the blood.…”

Section: Discussionmentioning

confidence: 99%

Assessment of antidiabetic potential and phytochemical profiling of Rhazya stricta root extracts

Mahmood

Kayani

Ahmed

et al. 2020

BMC Complement Med Ther

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Background Diabetes mellitus is a chronic disease characterized by hyperglycemia that may occur due to genetic, environmental or lifestyle factors. Natural remedies have been used to treat diabetes since long and many antidiabetic compounds of varied efficacies have been isolated from medicinal plants. Rhazya stricta has been used for decades for the treatment of diabetes mellitus and associated ailments. Considering the folkloric use of R. stricta against diabetes, it was aimed to investigate the effectiveness of its root extracts against diabetes through in vitro assays and in vivo studies using animal model along with phytochemical profiling through GCMS. Methods Various fractions of Rhazya stricta obtained through column chromatography were evaluated for a variety of assays including α-glucosidase, Dipeptidyl peptidase-IV (DPP-IV), β-secretase and Glucagon-like peptide-1 (GLP-1) secretion studies. For the in vivo studies the alloxan-induced diabetic mice were treated with root extracts and blood glucose levels, HbA1C, and other biochemical markers along with the histological study of the liver were done. The phytochemical identification was performed using an Agilent 7890B GC coupled to a 7010 Triple Quadrupole (MS/MS) system. GraphPad Prism software version 5.01 was used for statistical analysis. Results Majority of the extract fractions showed excellent results against diabetes by inhibiting enzymes DPP-IV (Up to 61%) and β-secretase (Up to 83%) with IC50s 979 μg/ml and 169 μg/ml respectively with increase in the GLP1 secretion. The results of in vivo studies indicated a marked reduction in blood glucose and HbA1c levels along with positive effects on other parameters like lipid profile, liver functions and renal functions of extract-treated mice as compared to control. The histological examination of the liver demonstrated hepatoprotective effects against diabetes led changes and various classes of phytochemicals were also identified through GCMS in different fractions. Conclusion The results revealed strong antidiabetic activity of R. stricta root with the potential to protect body organs against diabetic changes. Moreover, a variety of phytochemicals has also been identified through GCMS that might be responsible for the antidiabetic potential of Rhazya stricta root. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Assessment of antidiabetic potential and phytochemical profiling of Rhazya stricta root extracts

Mahmood

Kayani

Ahmed

et al. 2020

BMC Complement Med Ther

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“…Currently, the screening of the inhibitors of α-amylase and α-glucosidase of natural origin has received attention because this would avoid the side effects of commercial inhibitors for treating type-2 diabetes [ 10 ]. Extracts of natural plants with inhibitory α-glucosidase activity, such as tea and raspberry, are recommended as substitutes for synthetic drugs [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Polyphenols from Southern Chile Seaweed as Inhibitors of Enzymes for Starch Digestion

et al. 2020

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The increment of non-communicable chronic diseases is a constant concern worldwide, with type-2 diabetes mellitus being one of the most common illnesses. A mechanism to avoid diabetes-related hyperglycemia is to reduce food digestion/absorption by using anti-enzymatic (functional) ingredients. This research explored the potential of six common Chilean seaweeds to obtain anti-hyperglycemic polyphenol extracts, based on their capacity to inhibit key enzymes related with starch digestion. Ethanol/water hot pressurized liquid extraction (HPLE), which is an environmentally friendly method, was studied and compared to conventional extraction with acetone. Total polyphenols (TP), antioxidant activity, cytotoxicity and inhibition capacity on α-glucosidase and α-amylase were analyzed. Results showed that the Durvillaea antarctica (cochayuyo) acetone extract had the highest TP content (6.7 ± 0.7 mg gallic acid equivalents (GAE)/g dry seaweed), while its HPLE ethanol/water extract showed the highest antioxidant activity (680.1 ± 11.6 μmol E Trolox/g dry seaweed). No extract affected cell viability significantly. Only cochayuyo produced extracts having relevant anti-enzymatic capacity on both studied enzymes, showing a much stronger inhibition to α-glucosidase (even almost 100% at 1000 µg/mL) than to α-amylase. In conclusion, from the Chilean seaweeds considered in this study, cochayuyo is the most suitable for developing functional ingredients to moderate postprandial glycemic response (starchy foods), since it showed a clear enzymatic inhibition capacity and selectivity.

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“…Carbohydrate hydrolyzing enzymes including α-glucosidase may be utilized for blocking the breakdown of starch and disaccharide into glucose and made glucose less available for absorption into the blood and ultimately sugar elevated level into the blood can be controlled. 5 Protein tyrosine phosphatase 1B (PTP1B) is considered as the main regulator of body stored body fat, insulin resistance, and energy balance. Insulin controls various functions at the level of gene transcription, protein translation, and enzyme activity.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Content Determination of Different Species of Genus Caesalpinia belonging to Different Origin with Antidiabetic Activity

Parveen¹,

Zahra²,

Farooqi³

et al. 2017

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Aim:The main aim of the study is to investigate the phytochemical screening of C. decapetala along with the content determination of different species of genus Caesalpinia with respect to their antidiabetic activity and identification of most bioactive species belonging to different origins. Methods: To achieve our goal different species of genus Caesalpinia collected from China and Pakistan were subjected to open column chromatography, High Pressure Liquid Chromatography (HPLC), antioxidant, and antidiabetic assays for evaluation. Results: From η-BuOH fraction of C. decapetala extract, eight compounds were isolated using open column chromatography and identified as apigenin-7-rhamnoside (1), 4-O-methylepisappanol (2), caesalpinol (3), daucosterol (4), astragalin (5), kaempferol (6), quercitrin (7), and naringin (8) using Nuclear Magnetic Resonance (NMR) spectroscopy. HPLC analysis of different species of genus Caesalpinia showed that the most active antidiabetic compound 'quercitrin' was present more in C. pulcherrima followed by decreasing order in C. sappan, C.decapetala, and C. bonduc. Conclusion: The results indicated that quercitrin is the most bioactive content and C. pulcherrima is most bioactive specie of China origin from genus Caesalpinia.

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Review on Role of Natural Αlpha-Glucosidase Inhibitors for Management of Diabetes Mellitus

Cited by 28 publications

References 13 publications

Assessment of antidiabetic potential and phytochemical profiling of Rhazya stricta root extracts

Assessment of antidiabetic potential and phytochemical profiling of Rhazya stricta root extracts

Bioactive Polyphenols from Southern Chile Seaweed as Inhibitors of Enzymes for Starch Digestion

Phytochemical Screening and Content Determination of Different Species of Genus Caesalpinia belonging to Different Origin with Antidiabetic Activity

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