Reviews: Altered Laboratory Findings Associated with End‐Stage Renal Disease

Robitaille, Robert; Lafrance, Jean‐Philippe; Leblanc, Martine

doi:10.1111/j.1525-139x.2006.00192.x

Cited by 17 publications

(8 citation statements)

References 93 publications

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“…LDH is known to be elevated in patients on HD, increased by 20%-40% in patients with ESRD compared to normal volunteers (25). LDH concentrations in both of our groups were above the reference range in our study, but no particular relationship with platelet counts was established.…”

Section: Discussioncontrasting

confidence: 67%

Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C

Orășan¹,

Urian²,

Ciulei³

et al. 2018

JMMS

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Objectives. We evaluated platelet counts in end-stage renal disease and chronic viral hepatitis. Materials and Methods. We studied 70 patients with end-stage renal disease and chronic viral hepatitis and compared them to a control group of 45 patients without hepatitis. Results. The presence of viral hepatitis was associated with a higher prevalence of thrombocytopenia. Correlations between age, C-reactive protein, liver stiffness measurement, and platelet count were observed. C-reactive protein levels > 10 mg/dl were associated with a lower risk of thrombocytopenia in patients with end-stage renal disease and chronic viral hepatitis, yet age > 60 years, dialysis vintage > 10 years, aspartate and alanine aminotransferase levels > 20 IU/L, albumin levels < 3.5 g/dl, and fibrosis stage ≥ 3 were not related. Conclusions. Chronic viral hepatitis leads to a higher prevalence of thrombocytopenia. Platelet counts in these patients begin to decrease significantly once liver fibrosis reaches stage III. Keywords  thrombocytopenia, end-stage renal disease, chronic viral hepatitis Highlights ✓ Thrombocytopenia is a common occurrence in patients with end-stage renal disease undergoing hemodialysis; ✓ Chronic viral hepatitis B or C in end-stage renal disease patients does not impact platelet counts, suggesting that the natural course of liver disease is slowed in subjects undergoing hemodialysis

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Section: Discussioncontrasting

confidence: 67%

Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C

Orășan¹,

Urian²,

Ciulei³

et al. 2018

JMMS

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“…To our knowledge, serum concentrations can be increased for reasons other than muscle disease, such as exercise, muscle trauma, motor neuron disease, and renal disease. [ 27 – 29 ] As a result, caution is warranted when diagnosing muscle injury on the basis of elevated laboratory indices alone.…”

Section: Discussionmentioning

confidence: 99%

Muscle ultrasound

Hwang

Hsu²,

Lee³

et al. 2017

Medicine

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Our study aimed to evaluate the utility of muscle ultrasound in newborn screening of infantile-onset Pompe disease (IOPD) and to establish a system of severity grading. We retrospectively selected 35 patients with initial low acid alpha-glucosidase (GAA) activity and collected data including muscle ultrasound features, GAA gene mutation, activity/performance, and pathological and laboratory findings. The echogenicity of 6 muscles (the bilateral vastus intermedius, rectus femoris, and sartorius muscles) was compared to that of epimysium on ultrasound and rated either 1 (normal), 2 (mildly increased), or 3 (obviously increased). These grades were used to divide patients into 3 groups. IOPD was present in none of the grade-1 patients, 5 of 9 grade-2 patients, and 5 of 5 grade-3 patients (P < .001). Comparing grade-2 plus grade-3 patients to grade-1 patients, muscle ultrasound detected IOPD with a sensitivity and specificity of 100.0% (95% confidence interval [CI]: 69.2%–100%) and 84.0% (95% CI: 63.9%–95.5%), respectively. The mean number of affected muscles was larger in grade-3 patients than in grade-2 patients (4.2 vs. 2.0, P = .005). Mean alanine transaminase (ALT), aspartate transaminase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH) levels were differed significantly different between grade-3 and grade-1 patients (P < .001). Because it permits direct visualization of injured muscles, muscle ultrasound can be used to screen for IOPD. Our echogenicity grades of muscle injury also correlate well with serum levels of muscle-injury biochemical markers.

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“…In addition, in cardiomyopathy, tachycardia, left ventricular hypertrophy, pulmonary emboli, and renal dysfunction measurement of serum troponin level can be helpful. 9,17 –20…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Heart Function in Patients With Hemophilia

Amoozgar

Fath

Jooya

et al. 2015

Clin Appl Thromb Hemost

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There are conflicting reports about the protective effect of hemophilia on the occurrence of ischemic heart disease. This study focuses on evaluation of heart function in patients with hemophilia. Cross-sectional, case-control study was done on all patients with hemophilia A or B who came to hemophilia center, and data were compared to controls. The data were collected from their charts, and heart function was evaluated by 2-dimensional, Doppler and pulse tissue Doppler. The serum troponin I level was measured in all patients as a marker of myocardial damage. Fifty patients with hemophilia took part in this study. All of them were male with mean age 29.1 years. Systolic blood pressure (mean = 121.52 ± 11 vs 115.61 ± 9.81, P = .038) and diastolic (mean = 81.94 ± 4.51 vs 75.21 ± 3.95, P = .042) blood pressure were higher in the patients. Five (10%) patients had systolic hypertension and 7 (14%) patients had diastolic hypertension. The M-mode echocardiography results showed that interventricular septum in diastole in patients with hemophilia (mean 1.143 ± 0.29) was significantly thicker than the control group (mean 0.828 ± 0.22, P < .001). Tissue Doppler echocardiography showed that late diastolic velocity of septum (Aa; P = .030), systolic velocity (S) of lateral mitral valve ( P = .006), late diastolic velocity of lateral mitral (Aa) annulus ( P = .038), and late velocity of (Aa) tricuspid ( P = .004) had significant difference compared with the control group ( P < .05). Troponin enzyme level was < 0.1 in all patients. Patients with hemophilia had higher blood pressure and more hypertension. Echocardiographic study of patients with hemophilia showed some increase in septal thickness and changes in diastolic dysfunction.

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Reviews: Altered Laboratory Findings Associated with End‐Stage Renal Disease

Cited by 17 publications

References 93 publications

Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C

Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C

Muscle ultrasound

Evaluation of Heart Function in Patients With Hemophilia

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