Background. Conducting clinical studies to determine the factors determining the aseptic instability of knee joint endoprosthesis components is an urgent issue in modern orthopedics. The aim of the study was to determine some clinical factors of aseptic instability of knee joint endoprosthesis components. Materials and methods. Comprehensive research was conducted on 285 patients who underwent primary knee arthroplasty between 2010 and 2021, including 85 patients with clinical and radiological signs of aseptic instability of knee arthroplasty components (AIKAC). Also, 200 patients made up a control group with no signs of AIKAC instability observed. Clinical research methods included general, and special orthopedic methods of studying local changes in the knee joint. They included measurement of body mass index (BMI), overloading of the knee joint due to work, previous surgical interventions and early postoperative complications of primary arthroplasty, and presence of angular deformities in the knee joint. For the clinical assessment of the knee joint of patients after knee arthroplasty, we used our own point assessment of the state of the knee joint. Results. It was determined that significant factors for the development of instability of components of the knee joint endoprosthesis are both directly related to the patient (increase in BMI, difficult working conditions, the presence of operative interventions on the knee joint), and factors related to errors during the primary total arthroplasty (residual deformities of the knee joint and early postoperative complications). Conclusions. We determined important factors of aseptic instability of the knee joint in the patients after arthroplasty. Taking into account the results of this study will improve the diagnosis and treatment of aseptic instability of the knee joint.