“…Clinical signs of ophidiomycosis vary among individuals, from general signs such as lethargy, skin lesions, excessive shedding, to crusts, granulomas, corneal opacity, and ulcers on the head and body in more severe cases (29). Ophidiomycosis has the potential to cause widespread morbidity and mortality in snakes (31,32,35,40,41) but the mode of infection, specific mechanisms of pathology, and physiological responses by infected individuals are unclear despite the value of this information for understanding and mitigating the impact of this disease (29,42). Specifically, the two key elements of SFD pathology that are still unknown are (a) Is the snake host response is localized to the skin, as in the case of Bd infections in amphibians, or whether SFD is more systemic disease, like the white nose syndrome in bats?…”