Reward-system effect (BAS rating), left hemispheric “unbalance” (alpha band oscillations) and decisional impairments in drug addiction

Balconi, Michela; Finocchiaro, Roberta; Canavesio, Ylenia

doi:10.1016/j.addbeh.2014.02.007

Cited by 62 publications

(58 citation statements)

References 63 publications

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“…We used a reproducible unbiased definition of ROIs derived from a large, publicly available dataset (https://neurosynth.org). Whereas a prior EEG study in cocaine users found higher BAS scores and, separately, relative left asymmetric activity during decision-making (Balconi et al, 2014b), we extend the literature in reporting for the first time in an fMRI study a direct correlation between BAS and left OFC activity across individuals.…”

Section: Discussionsupporting

confidence: 71%

“…An EEG study by Balconi et al observed higher BAS Reward Responsiveness and BAS Drive in cocaine users compared to controls. In addition, there was relatively increased left compared to right alpha power when participants made disadvantageous decisions on the IGT (Balconi et al, 2014b), suggesting that behavioral approach was associated with left relative to right hemisphere activity. However, this study did not correlate EEG with behavioral approach.…”

Section: Discussionmentioning

confidence: 99%

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Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence

Yamamoto

Banich

Regner

et al. 2017

Drug and Alcohol Dependence

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Behavioral approach, defined as behavior directed toward a reward or novel stimulus, when elevated, may increase one’s vulnerability to substance use disorder. Behavioral approach has been associated with relatively greater left compared to right frontal activity; behavioral inhibition may be associated with relatively greater right compared to left frontal brain activity. We hypothesized that substance dependent individuals (SDI) would have higher behavioral approach than controls and greater prefrontal cortical activity during decision-making involving reward. We hypothesized that behavioral approach would correlate with left frontal activity during decision-making and that the correlation would be stronger in SDI than controls. 31 SDI and 21 controls completed the Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales and performed a decision-making task during fMRI. Orbitofrontal (OFC) and dorsolateral prefrontal activity were correlated with BIS and BAS scores. Compared to controls, SDI had higher BAS Fun Seeking scores (p<0.001) and worse decision-making performance (p=0.004). BAS Fun Seeking correlated with left OFC activity during decision-making across group (r=0.444, p<0.003). The correlation did not differ by group. There was no correlation between BIS and right frontal activity. Left OFC may play a role in reward-related decision-making in substance use disorder especially in individuals with high behavioral approach.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence

Yamamoto

Banich

Regner

et al. 2017

Drug and Alcohol Dependence

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“…The present results also offer a valid background to explain the cortical and behavioral mechanisms underlying gambling behavior or drug addiction. 27,28 Moreover, they potentially support specific treatment strategies to intervene to reduce the reward-bias effect in gambling behavior, by conditioning the subjects' response to a delayed reward more than to an immediate gain. In parallel, they may suggest the utility to integrate this reward-related intervention to a more specific cognitive support, to induce a realistic representation of the situation based on a functional metacognitive strategy.…”

Section: Discussionmentioning

confidence: 99%

“…More reward-dependent subjects should make more risky, disadvantageous choices on the IGT. 27,28 BAS construct, specifically BAS-reward subscale, is supposed to be able to distinguish subjects who are potentially more reward-dependent. However, no previous study directly considered the significance of Carver and White's BIS/BAS measures for gambling behavior, by comparing the high-versus low-BAS construct and specifically BASreward subscale, with IGT performance.…”

mentioning

confidence: 99%

Reward Sensitivity (Behavioral Activation System), Cognitive, and Metacognitive Control in Gambling Behavior: Evidences From Behavioral, Feedback-Related Negativity, and P300 Effect

Balconi

Finocchiaro

Canavesio³

2015

JNP

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The present research explored the main factors able to influence the subjects' choices in the case of decisions and distinguish between high- and low-risk decisions. Behavioral responses (Iowa Gambling Task [IGT]), meta-cognitive strategy, and event-related potential (feedback-related negativity [FRN] and P300) effects were used as predictive markers of gambling behavior. Behavioral activation system (BAS)-reward measure was applied to distinguish between high-BAS and low-BAS. It was found that higher-BAS opted in favor of the immediate reward, with a concomitant dysfunctional metacognition of their strategy. Finally, a consistent "reward bias" affected the high-BAS performance reducing the P300 and FRN in response to unexpected (loss) events. The cortical localization (sLORETA) of ERPs showed the contribution by distinct anterior and posterior areas.

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“…Functional near Infrared Spectroscopy is being used to find potential biological markers for assessment of addiction and its recovery [85]. Alpha frequency waves are being explored for reward-system effect to heal decisional impairments contributing to and damaged by drug addiction [86,87]. Stem cell and frequency research are carving the path, meandering from present to the future.…”

Section: Discussionmentioning

confidence: 99%

Integrating the Science of Addiction and the Science of Wellbeing

Gilley¹

2017

J Alcohol Drug Depend

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A gap between public understanding, cutting edge brain science and the practice of addiction treatment has created hardship for those suffering. New perspective replaces the term addiction with the new concept of a continuum of substance use. Substance Use Disorder (SUD) is now regarded as a manifestation of Reward Deficiency Syndrome, which contributes to a spectrum of disorders related to genetic polymorphisms, especially in regard to impulsive, addictive and compulsive behaviors. The new brain science of addiction requires neurological medical intervention and novel treatment with nutraceuticals, the building blocks of neurotransmission. Innovative alterative holistic and wellness therapies are proving to be beneficial in helping the sufferer thrive despite chronic neurological challenge.

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Reward-system effect (BAS rating), left hemispheric “unbalance” (alpha band oscillations) and decisional impairments in drug addiction

Cited by 62 publications

References 63 publications

Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence

Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence

Reward Sensitivity (Behavioral Activation System), Cognitive, and Metacognitive Control in Gambling Behavior: Evidences From Behavioral, Feedback-Related Negativity, and P300 Effect

Integrating the Science of Addiction and the Science of Wellbeing

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