-This paper deals with the adaption of construction schedule due to real-time data. This real-time data needs to be evaluated regarding the effects on the schedule. If significant delays or other problems are identified, the schedule should be adapted. That means that under the existing condition a new schedule needs to be generated. Thereby, different constraints of the target schedule like contracted delivery dates, milestones or resource allocation should be considered. In the presented approach these additional constraints are modeled and integrated into a simulation model which represents the planned target schedule. By applying simulationbased optimization a new efficient schedule is generated considering existing and additional so-called target constraints. If the identified delays are that large, such that an adaption considering all significant constraints is not possible, some constraints, like resource capacity or shifts, can be relaxed. The proposed concept for reactive adaptation of construction schedules by applying simulation-based optimization is verified by a standard construction schedule example.