RFID sensors as the common sensing platform for single-use biopharmaceutical manufacturing

Abstract

The lack of reliable single-use sensors prevents the biopharmaceutical industry from fully embracing single-use biomanufacturing processes. Sensors based on the same detection platform for all critical parameters in single-use bioprocess components would be highly desirable to significantly simplify their installation, calibration and operation. We review here our approach for passive radio-frequency identification (RFID)-based sensing that does not rely on costly proprietary RFID memory chips with an analog input but rather implements ubiquitous passive 13.56 MHz RFID tags as inductively coupled sensors with at least 16 bit resolution provided by a sensor reader. The developed RFID sensors combine several measured parameters from the resonant sensor antenna with multivariate data analysis and deliver unique capability of multiparameter sensing and rejection of environmental interferences with a single sensor. This general sensing approach provides an elegant solution for both analytical measurement and identification and documentation of the measured location.

Sensors for disposable bioreactors

“…Pioneering work in this field has been done by Potyrailo et al . . They presented passive RFID sensors for physical, chemical, and biological sensing .…”

Functional and Consumption Analysis of Integrated Circuits Supplied by Inductive Power Transfer by Powering Modulation and Lock-In Infrared Imaging

“…In addition, |Δ | , , depends on the local power density of each block fixed by the electrical behavior at f pow (high frequency), which is represented by and , in Eq. (5). Thanks to the frequency down conversion offered by the proposed modulations (see Figs.…”

“…This technology is based on the electromagnetic coupling between the platform (usually, an external coil) with a coil integrated in the remote device. During the last years, IPT has been implemented in a wide range of applications, from powering of low power single-chip systems (e.g., radio frequency identification -RFID-tags, access cards or wireless sensors) [4,5] to high-power systems (e.g., wireless battery charge in electric or hybrid-electric vehicles, or induction cooking) [6,7,8,9]. Focusing on low power applications, several recent publications show an increasing interest on integrating IPT-powered systems and data transmission antennas into the same chip [10,11,12,13].…”

Antenna Sensors in Passive Wireless Sensing Systems

“…When a reader antenna is placed in the near field of an antenna sensor, these two antennas are inductively coupled. Therefore, the impedance or scattering parameter (S-parameter) of the sensor antenna can be measured directly from the S 11 parameter of the reader antenna (Potyrailo et al 2011;Jang and Kim 2012;Daliri et al 2012). The reading range of the near-field communication, however, is comparable with that of the inductively coupled sensors.…”