2020
DOI: 10.1002/jbm.a.36870
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RGD‐functionalized supported lipid bilayers modulate pre‐osteoblast adherence and promote osteogenic differentiation

Abstract: Biomaterial integration into bone requires optimal surface conditions to promote osteoprogenitor behavior, which is affected by integrin-binding via arginine-glycine-aspartate (RGD). RGD-functionalized supported lipid bilayers (SLBs) might be interesting as biomaterial coating in bone regeneration, because they allow integration of proteins, for example, growth factors, cytokines, and/or antibacterial agents. Since it is unknown whether and how they affect osteoprogenitor adhesion and differentiation, the aim … Show more

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Cited by 5 publications
(2 citation statements)
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References 51 publications
(153 reference statements)
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“…3032 In fact, a fused peptide construct, containing both RGDS and laminin-derived YIGSR (Tyr-Ile-Gly-Ser-Arg) motifs, 33 exhibited 10-fold higher adhesion to endothelial cells than that to SMCs. 911 In addition, RGD-functionalized biomaterials surface promotes not only cell adhesion but also various in vitro and in vivo phenomena, such as proliferation, 34 differentiation, 3436 , endothelialization, 37 and wound healing. 38 The CCM BPs linked to these peptides could be effectively functionalized on the CCM surface and provided biocompatibility.…”
Section: Discussionmentioning
confidence: 99%
“…3032 In fact, a fused peptide construct, containing both RGDS and laminin-derived YIGSR (Tyr-Ile-Gly-Ser-Arg) motifs, 33 exhibited 10-fold higher adhesion to endothelial cells than that to SMCs. 911 In addition, RGD-functionalized biomaterials surface promotes not only cell adhesion but also various in vitro and in vivo phenomena, such as proliferation, 34 differentiation, 3436 , endothelialization, 37 and wound healing. 38 The CCM BPs linked to these peptides could be effectively functionalized on the CCM surface and provided biocompatibility.…”
Section: Discussionmentioning
confidence: 99%
“…As biocompatible coatings on solid surfaces, SLBs can be incorporated as functional elements into highly sensitive, surface-based measurement devices. 150,179 Aside from fundamental research into membrane biology, SLBs have proven useful for various surface coating and sensing applications across the biomedical, [180][181][182][183] environmental, [184][185][186] and food [187][188][189] sectors. Currently, the most widely used method to fabricate SLBs is the vesicle fusion method in which spherical lipid vesicles adsorb and rupture spontaneously on a target surface to form a two-dimensional SLB.…”
Section: Introductionmentioning
confidence: 99%