The infl uence of Nano-SiO 2 (NS) content and lignocellulosic material addition on hydration behavior of cement paste was studied through measurement of hydration temperature, initial and fi nal setting time of cement paste and compressive strength of hardened cement paste. Besides, the amount of NS, particle size of reed and bagasse as lignocellulosic materials and bagasse to reed particles weight ratio were selected as manufacturing variables for cement-bonded particleboard (CBPB) each at fi ve levels. The relationships between independent parameters and output variables (modulus of rupture (MOR), modulus of elasticity (MOE) and internal bonding (IB)) were modeled using response surface methodology (RSM) based on mathematical model equations (second-order multiple linear regression model) by computer simulation programming. The results indicated that cement pastes containing 3 wt.% Nano-SiO 2 content mixed with milled reed or bagasse particles enhanced maximum hydration temperature; however, the time of reaching the main rate peak shortened. Besides, the increase of SiO 2 replacement shortened the setting time. On the other hand, using reed particles, initial and fi nal setting times of cement prolonged, while bagasse particles shortened initial and fi nal setting times. Analysis of variance (ANOVA) was performed to determine the adequacy of the mathematical model and its respective variables. The interaction effect curves of the independent variables obtained from simulations showed a good agreement between the measured MOR, MOE and IB of CBPB and predicted values obtained by the developed models, and hence, the proposed concept was verifi ed.