Rheological properties of human blood plasma — A comparison of measurements with three different viscometers

Gräf, Christian; Barras, Jean‐Luc

doi:10.1007/bf01920630

Cited by 20 publications

(11 citation statements)

References 7 publications

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“…If there is a set of events having the same reaction rate, Gillespie's algorithm [13] is used to reduce the computational load. For the set of N set possible free receptor-ligand pairs, each with its L sep 5l, we select the time to the next bond formation for the set, as shown in Equation 17:…”

Section: Competition For the Next Eventmentioning

confidence: 99%

Event‐Tracking Model of Adhesion Identifies Load‐Bearing Bonds in Rolling Leukocytes

et al. 2009

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Objectives P-selectin binding to P-selectin glycoprotein ligand (PSGL)-1 mediates leukocyte rolling under conditions of inflammation and injury. The objectives were to develop an efficient, high temporal resolution model for direct simulation of leukocyte rolling, and then to conduct a study of load-bearing bonds using the model. Methods A stochastic π-calculus-driven Event Tracking Model of Adhesion was developed and compared with experimental data. Multiple simulations for each case were conducted to obtain high confidence numerical characteristics of leukocyte rolling. Results Leukocyte rolling and the underlying P-selectin—PSGL-1 bonds were studied under low wall shear rate (25-50 s-1) conditions from measured parameters of leukocyte rolling and bond properties. For the first time, the location, number, lifetime, history, and kinetics of load-bearing bonds and their influence on cell rolling are identified. Instantaneous cell displacements, translational and rotational velocities, and cell-endothelium distances are derived. The model explains the commonly observed “stop-start” type rolling behavior and reveals that a few load-bearing bonds are sufficient to support rolling while a large number of bonds dissociate before becoming load-bearing. Conclusions The presented model provides a method for precise and direct simulation of leukocyte rolling, and sets a foundation upon which further refinements can be introduced.

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Section: Competition For the Next Eventmentioning

confidence: 99%

Event‐Tracking Model of Adhesion Identifies Load‐Bearing Bonds in Rolling Leukocytes

et al. 2009

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“…The value for n is slightly reduced to 0.78, which is within the allowable deviation range. (Note that in the measurement by Graf and Barras [23], the standard deviation for the power-law index is 0.07.) We use the same value for l Ã as above, namely, 3.16 mPa s n .…”

Section: The Effect Of Non-newtonian Properties On the Filtration Velmentioning

confidence: 98%

“…(8), we specify the power-law index n and consistency index l Ã to be 0.81 and 3.16 mPa s n , respectively. The values for n and l Ã are calculated from the experimental data measured with a Contraves Low Shear 30 Couette Viscometer [23]. The data is fitted with the constitutive equation of power-law fluid (l a ¼ l Ã _ c nÀ1 ), equivalent to a straight line on the following log-log plot with the correlation coefficient r = À0.9672 (Fig.…”

Section: The Effect Of Non-newtonian Properties On the Filtration Velmentioning

confidence: 99%

“…Although the blood cells are absent, the plasma still behaves like a non-Newtonian fluid at low shear rates [22]. The measurements of the rheological properties of plasma with three different viscometers were in comparison, which showed that the plasma is a non-Newtonian fluid with shear thinning behavior [23]. Sharma and Bhat [24] performed the measurements of plasma viscosity by using Rheometer LS30, which allows measuring the viscosity in the middle and low shear rate ranges.…”

Section: Introductionmentioning

confidence: 99%

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Non-Newtonian effects on low-density lipoprotein transport in the arterial wall

Hong¹,

Fu²,

Lin³

et al. 2012

Journal of Non-Newtonian Fluid Mechanics

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“…35,39 In general, non-Newtonian plasma which in¯ltrate through porous layers, can be described by the Darcy equation for the power-law°uid 36,40 as…”

Section: Non-newtonian Formulationmentioning

confidence: 99%

Non-Newtonian effects of blood on LDL transport inside the arterial lumen and across multi-layered arterial wall with and without stenosis

Deyranlou¹,

Niazmand

Sadeghi

et al. 2016

Int. J. Mod. Phys. C

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Blood non-Newtonian behavior on low-density lipoproteins (LDL) accumulation is analyzed numerically, while°uid-multilayered arteries are adopted for nonstenotic and 30%-60% symmetrical stenosed models. Present model considers non-Newtonian e®ects inside the lumen and within arterial layers simultaneously, which has not been examined in previous studies. Navier-Stokes equations are solved along with the mass transport convection-di®usion equations and Darcy's model for species transport inside the luminal°ow and across wall layers, respectively. Carreau model for the luminal°ow and the modi¯ed Darcy equation for the power-law°uid within arterial layers are employed to model blood rheological characteristics, appropriately. Results indicate that in large arteries with relatively high Reynolds number Newtonian model estimates LDL concentration patterns well enough, however, this model seriously incompetent for regions with low WSS. Moreover, Newtonian model for plasma underestimates LDL concentration especially on luminal surface and across arterial wall. Therefore, applying non-Newtonian model seems essential for reaching to a more accurate estimation of LDL distribution in the artery. Finally, blood°ow inside constricted arteries demonstrates that LDL concentration patterns along the stenoses inside the luminal°ow and across arterial layers are strongly in°uenced as compared to the nonstenotic arteries. Additionally, among four stenosis severity grades, 40% stenosis is prone to more LDL accumulation along the post-stenotic regions. Int. J. Mod. Phys. C Downloaded from www.worldscientific.com by CAMBRIDGE UNIVERSITY on 08/18/15. For personal use only. Non-Newtonian e®ects of blood on LDL transport 1650003-3 Int. J. Mod. Phys. C Downloaded from www.worldscientific.com by CAMBRIDGE UNIVERSITY on 08/18/15. For personal use only.

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Rheological properties of human blood plasma — A comparison of measurements with three different viscometers

Cited by 20 publications

References 7 publications

Event‐Tracking Model of Adhesion Identifies Load‐Bearing Bonds in Rolling Leukocytes

Event‐Tracking Model of Adhesion Identifies Load‐Bearing Bonds in Rolling Leukocytes

Non-Newtonian effects on low-density lipoprotein transport in the arterial wall

Non-Newtonian effects of blood on LDL transport inside the arterial lumen and across multi-layered arterial wall with and without stenosis

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