Rheology of colloidal particles in lyotropic hexagonal liquid crystals: the role of particle loading, shape, and phase transition kinetics

Kulkarni, Siddharth; Thareja, Prachi

doi:10.1007/s00397-015-0896-1

Cited by 7 publications

(2 citation statements)

References 50 publications

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“…This shear‐thinning effect in the high shear rate regime may be attributed to the high aspect ratio of the cylindrical micelles of the surfactant causing them to be reorganized to orient along the flow direction under shear. Similar rheological behavior has been reported for the isotropic solutions of surfactants and inorganic nanowires . The addition of 0.10 wt% SWNTs to the isotropic phase results in little change in rheological properties.…”

Section: Resultssupporting

confidence: 81%

Ordered Nanostructures of Carbon Nanotube–Polymer Composites from Lyotropic Liquid Crystal Templating

Kasprzak

Scherzinger

Sarkar

et al. 2018

Macro Chemistry & Physics

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A series of polymer nanocomposites containing single‐walled carbon nanotubes (SWNTs) are prepared from polymerizable quaternary ammonium surfactants using photo‐polymerization and investigated by means of polarized optical microscopy, small‐angle X‐ray scattering, and rheological measurements. The surfactant monomers with various alkyl chains of nonpolar tails form lyotropic liquid crystalline (LLC) mesophases in aqueous medium with hexagonal packing of cylindrical micelles. The physical adsorption of nonpolar tails of surfactants on the surface of SWNTs results in de‐bundled nanotubes. The LLC phase diagram is investigated as functions of alkyl chain length, concentration, temperature, and SWNTs. As such, addition of SWNTs does not change the hexagonal mesophases but enhances the order–disorder transition temperatures and alters the rheological behaviors. After photo‐polymerization, the microstructures of hexagonal packing are changed while addition of SWNTs does not disrupt the resulting microstructures. The polymerized composites are consistent with both lamellar and gyroid nanostructures and a possible model is proposed to interpret the observed phenomenon. Under the shear flow, the defect‐free monodomain structures are obtained in the LLC phase and subsequently locked in the solid film after polymerization.

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Section: Resultssupporting

confidence: 81%

Ordered Nanostructures of Carbon Nanotube–Polymer Composites from Lyotropic Liquid Crystal Templating

Kasprzak

Scherzinger

Sarkar

et al. 2018

Macro Chemistry & Physics

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“…The special structures provide incorporation of drugs with different solubility, including hydrophilic, hydrophobic and amphiphilic molecules (Conn & Drummond, 2013;Rajabalaya et al, 2017) and also tunable release rate (Rizwan & Boyd, 2015;Abd-Allah et al, 2016;Huang & Gui, 2018). LLC exhibits perfect performance on mucosal (Huang et al, 2017), transdermal (Peng et al, 2015;Musa et al, 2017), periodontal (Mei et al, 2017a;Zheng et al, 2018), subcutaneous (Mei et al, 2017b) and other parenteral drug delivery (Wan et al, 2015;Qin et al, 2016), due to its high drug-loading capacity, appropriate viscoelasticity and good biocompatibility (Abd-Allah et al, 2016;Kulkarni & Thareja, 2016).…”

Section: Introductionmentioning

confidence: 99%

Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs

Zhang

Xiao²,

Huang

et al. 2020

Drug Delivery

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Smart phase transformation systems@hard capsule (SPTS@hard capsule) based on lyotropic liquid crystalline (LLC) were developed for oral sustained release in this study. Doxycycline hydrochloride (DOXY) and meloxicam (MLX) were used as hydrophilic and hydrophobic model drug, respectively. Two systems were added with different additives, that is, gelucire 39/01, PEG 1000 and Tween 80 to adjust their melting point and release profiles. The phase transformation of these systems could be triggered by water as well as temperature. They could spontaneously transform into cubic phase or hexagonal phase when coming across with water, to achieve the 24 h sustained release profile. In addition, the obtained systems could switch between semisolid state and liquid state when temperature changed within room temperature and body temperature, which facilitated the phase transformation in gastrointestinal tract and during their encapsulation into hard capsules. LLC-based SPTS@hard capsule revealed potential for the industrialization of its oral administration on account of its drugs accommodation with different solubility, controllable release profile and simple preparation process.

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Suspensions of titania nanoparticle networks in nematic liquid crystals: rheology and microstructure

Kulkarni

Thareja

2017

Rheol Acta

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Rheology of colloidal particles in lyotropic hexagonal liquid crystals: the role of particle loading, shape, and phase transition kinetics

Cited by 7 publications

References 50 publications

Ordered Nanostructures of Carbon Nanotube–Polymer Composites from Lyotropic Liquid Crystal Templating

Ordered Nanostructures of Carbon Nanotube–Polymer Composites from Lyotropic Liquid Crystal Templating

Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs

Suspensions of titania nanoparticle networks in nematic liquid crystals: rheology and microstructure

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