Rheumatoid arthritis in Burkina Faso: clinical and serological profiles

Abstract

The objective of this work was to study the clinical and serological profiles of rheumatoid arthritis in Burkina Faso (West Africa). It is a cross-sectional study conducted from March 2006 to February 2009 in the Internal Medicine Department of the University Hospital Yalgado Ouedraogo. All patients seen in the rheumatologic consultation unit during this period, with rheumatoid arthritis fulfilling the ACR criteria, were routinely selected. The determination of anticyclic citrullinated peptide antibodies (ACPA) was carried out with a computerized method (Elia CCP, Phadia AB, Uppsala, Sweden). Values higher than 10 IU/l were considered positive. Forty-eight cases of rheumatoid arthritis (RA) were recruited throughout the study period among 2,194 (2.2 %) patients. Forty-two files were subjected to the study. There were 34 women and 8 men. The average age was 41.70 ± 13 years with extremes of 22 and 71 years. The average duration of the disease was 86.17 ± 82.01 months with extremes of 8 and 360 months. Rheumatoid factors (RF) were positive in 21 out of 30 patients (70.0%). The determination of ACPA carried out in all the patients was positive in 34 (81%) patients; their average value was 217 IU/l with extremes of 38 and 1,170. RF and ACPA were associated to bones erosions (p = 0.0001). Twenty-two patients were placed on methotrexate, eight on hydroxychloroquine, and three on salazopyrine. Nine were given only NSAIDs or prednisolone. No patients had had a biotherapy agent. The frequency of RA was low in our study compared to other African studies published so far. The particularity of RA cases reported in African series, including ours, is the rarity of extra-articular manifestations of the disease. The severity of the disease at presentation in the rheumatology clinic may be due to their late consultation among other causes.

Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations

“…The strong seropositivity to the rheumatoid factor (54.5%) and to the anti-CCP antibodies (89.2%) noted in this study was also reported by Ndongo (rheumatoid factor: 78% and anti-CCP: 90%) [25] and by Ouédraogo (rheumatoid factor: 70% and anti-CCP: 80%) [24]. In the western literature we note the prevalence of the factor and superimpose able antibodies anti-CCP to these data [29] [30] [31].…”

“…In a study assessing the structural damage in the RA in Benin Zomalhèto, et al listed some characteristic articular deformations in 7 cases in 10 and over half of patients had a score of Larsen superior to 40 [23]. In Burkina, 9 patients in 10 presented at least a stage II of radiological Steinbrecher according to Ouédraogo et al [24].…”

Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden

“…The Journal of on May 9, 2018 -Published by www.jrheum.org Downloaded from Burkina Faso (81%), Egypt (85%), Cameroon (95%), and Senegal (91%) 3,31,32,33 . Thus, there seems to be a rather uniform finding of a higher female preponderance of RA in Africa as compared with in Europe.…”

Systemic Autoimmune Diseases: Not So Rare in Black Africans

“…RA presently constitutes 10 -15% of the rheumatologic cases seen in many of the rheumatology clinics in Nigeria(unreported observation). Other reports from Burkina Faso [9]; Kenya [10]; Cameroun [11]; South Africa [12]; Democratic Republic of Congo [13]; Senegal [14]; Zambia [15] also indicate that this condition may not be rare after all.…”