Rhombencephalitis Caused by<i>Listeria monocytogenes</i>in Humans and Ruminants: A Zoonosis on the Rise?

Oevermann, Anna; Zurbriggen, Andreas; Vandevelde, M.

doi:10.1155/2010/632513

Cited by 89 publications

(164 citation statements)

References 324 publications

(415 reference statements)

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“…The CNS is frequently involved in both, animal and human cases, and accounts for the high mortality rate associated with listeriosis (Oevermann et al, 2010b). Most commonly, Listeria CNS infections in ruminants occur as rhombencephalitis, i.e.…”

Section: Cns Infectionmentioning

confidence: 99%

Listeria monocytogenes infection in ruminants: Is there a link to the environment, food and human health? A review

Walland¹,

Lauper²,

Frey³

et al. 2015

SAT

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Listeria (L.) monocytogenes is widely distributed in the environment, but also has the ability to cause serious invasive disease in ruminants and humans. This review provides an overview of listeriosis in ruminants and discusses our insufficient understanding of reservoirs and possible cycling ofL. monocytogenes between animal and human hosts, food and the environment. It indicates gaps in our knowledge of the role of genetic subtypes in L. monocytogenes ecology and virulence as well as risk factors, in vivo diagnostics and pathogenesis of listeriosis in ruminants. Filling these gaps will contribute to improving the control of L. monocytogenes and enhancing disease prevention. As the prevalence of listeriosis in ruminants in Switzerland is likely to be underestimated, propositions concerning improvement options for surveillance of listeriosis in ruminants are provided. Summary Listeria (L.) monocytogenes is widely distributed in the environment, but also has the ability to cause serious invasive disease in ruminants and humans. This review provides an overview of listeriosis in ruminants and discusses our insufficient understanding of reservoirs and possible cycling of L. monocytogenes between animal and human hosts, food and the environment. It indicates gaps in our knowledge of the role of genetic subtypes in L. monocytogenes ecology and virulence as well as risk factors, in vivo diagnostics and pathogenesis of listeriosis in ruminants. Filling these gaps will contribute to improving the control of L. monocytogenes and enhancing disease prevention. As the prevalence of listeriosis in ruminants in Switzerland is likely to be underestimated, propositions concerning improvement options for surveillance of listeriosis in ruminants are provided.

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Section: Cns Infectionmentioning

confidence: 99%

Listeria monocytogenes infection in ruminants: Is there a link to the environment, food and human health? A review

Walland¹,

Lauper²,

Frey³

et al. 2015

SAT

View full text Add to dashboard Cite

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“…Listeria monocytogenes se aisló por primera vez en un ser humano en 1921, pero solo en 1980 se reconoció como causante de una enfermedad transmitida por la comida y potencialmente fatal (10). Frecuentemente, se encuentra como agente causal de casos esporádicos de meningitis (±0,5 por 100.000 al año), la mayoría asociados a consumo de alimentos contaminados, con una incidencia anual de 1 a 10 casos por millón.…”

Section: Discussionunclassified

“…Frecuentemente, se encuentra como agente causal de casos esporádicos de meningitis (±0,5 por 100.000 al año), la mayoría asociados a consumo de alimentos contaminados, con una incidencia anual de 1 a 10 casos por millón. Tiene una tasa de mortalidad de 24 a 62 %, a pesar del tratamiento antimicrobiano adecuado (10,11).…”

Section: Discussionunclassified

“…Una vez en el tallo, se disemina rostralmente a los centros cerebrales altos y caudalmente a la médula espinal, a lo largo de las conexiones axonales, por lo cual rara vez entra en contacto con el líquido cefalorraquídeo. El compromiso de neuronas motoras y sensitivas, indica que la bacteria se disemina anterógrada y retrógradamente por migración axonal (10). Nuestro caso favorece esta teoría; suponemos que luego del consumo de leche no pasteurizada, L. monocytogenes probablemente infectó la mucosa En un estudio descriptivo en Noruega, de 19 casos de encefalitis del tallo cerebral, se encontró que los infiltrados inflamatorios estaban predominantemente en los núcleos, tractos y regiones intraparenquimatosas de los nervios craneales que inervan la orofaringe (V, VII, IX, X y XII) (13).…”

Section: Discussionunclassified

“…La romboencefalitis fue descrita por primera vez en 1957 por Eck, como una forma inusual de listeriosis y suele aparecer en pacientes previamente sanos, contrariamente a la meningitis. El curso clínico se inicia con pródromos inespecíficos como cefalea, malestar general, náuseas, vómito y fiebre, que duran de 4 a 10 días, seguidos de una disfunción progresiva del tallo cerebral con compromiso de los nervios craneales, hemiparesia o cuadriparesia, déficit sensitivo, insuficiencia respiratoria, deterioro de la conciencia y, algunas veces, convulsiones (10).…”

Section: Discussionunclassified

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Encefalitis del tallo cerebral y mielitis por Listeria monocytogenes: caso clínico y revisión del tema

et al. 2013

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La romboencefalitis por Listeria monocytogenes es una presentación poco común de la listeriosis del sistema nervioso central; sin embargo, es la presentación más común en personas inmunocompetentes. Aun más rara es la combinación de romboencefalitis con mielitis causada por L. monocytogenes; no obstante, en este artículo se reporta un caso de encefalitis del tallo y mielitis grave en un paciente sin compromiso del sistema inmunitario. Se presenta un paciente de 21 años de edad, sin deficiencias del sistema inmunitario, que consumió productos lácteos no pasteurizados y, posteriormente, presentó un cuadro de cefalea, vómito, deterioro de su estado general y, finalmente, alteración del estado de conciencia y muerte. Consultó al Instituto Neurológico de Colombia y se hizo diagnóstico de encefalitis del tallo y mielitis por L. monocytogenes. Se discuten las diferencias entre el caso presentado y los reportados en la literatura científica. Ante un paciente con signos de compromiso del tallo cerebral, de posible origen infeccioso, es prudente iniciar tratamiento antibiótico para L. monocytogenes y, en caso de poca respuesta, escalar rápidamente en dicho tratamiento. También lo es extender el estudio radiológico hacia la columna vertebral, con el fin de descartar compromiso de la médula espinal. Brainstem encephalitis and myelitis due to Listeria monocytogenes: a case report and literature reviewBrainstem encephalitis caused by Listeria monocytogenes is an uncommon form of central nervous system listeriosis; however, it is the most common presentation in immunocompetent individuals. Here, we describe an even more rare combination of rhombencephalitis with severe myelitis caused by L. monocytogenes in an immunocompetent patient. We report the case of a 21-year-old immunocompetent patient who consumed unpasteurized dairy products and experienced headache and vomiting that progressed to an impaired general condition, altered consciousness and ultimately death. The patient had presented to the Neurological Institute of Colombia (INDEC in Spanish) for consultation and was diagnosed with brainstem encephalitis and myelitis caused by Listeria monocytogenes. The differences between this particular case and those reported in the literature will be discussed. It is advisable to initiate antibiotic treatment for Listeria monocytogenes if a patient shows signs of brainstem compromise of possible infectious origin and quickly intensify treatment if there is no or minimal response. It is also necessary to extend radiological assessment to include the spinal column to rule out spinal cord involvement. Keywords Contribución de los autores:Aracelly Castro, Olga Hernández y Carlos Santiago hicieron la revisión del tema y la escritura del artículo. Alejandro Guerra facilitó el caso del paciente. Piedad Urueña facilitó la revisión de las imágenes y su interpretación específica para este artículo.Listeria monocytogenes es un bacilo Gram positivo que infecta al ser humano principalmente por el consumo de alimentos contaminados y que ha mos...

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Dissociation of innate immune responses in microglia infected with Listeria monocytogenes

Frande-Cabanes

Fernández-Prieto

Calderon-Gonzalez

et al. 2013

Glia

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Microglia, the innate immune cells of the brain, plays a central role in cerebral listeriosis. Here, we present evidence that microglia control Listeria infection differently than macrophages. Infection of primary microglial cultures and murine cell lines with Listeria resulted in a dual function of the two gene expression programmes involved in early and late immune responses in macrophages. Whereas the bacterial gene hly seems responsible for both transcriptional programmes in macrophages, Listeria induces in microglia only the tumor necrosis factor (TNF)‐regulated transcriptional programme. Listeria also represses in microglia the late immune response gathered in two clusters, microbial degradation, and interferon (IFN)‐inducible genes. The bacterial gene actA was required in microglia to induce TNF‐regulated responses and to repress the late response. Isolation of microglial phagosomes revealed a phagosomal environment unable to destroy Listeria. Microglial phagosomes were also defective in several signaling and trafficking components reported as relevant for Listeria innate immune responses. This transcriptional strategy in microglia induced high levels of TNF‐α and monocyte chemotactic protein‐1 and low production of other neurotoxic compounds such as nitric oxide, hydrogen peroxide, and Type I IFNs. These cytokines and toxic microglial products are also released by primary microglia, and this cytokine and chemokine cocktail display a low potential to trigger neuronal apoptosis. This overall bacterial strategy strongly suggests that microglia limit Listeria inflammation pattern exclusively through TNF‐mediated responses to preserve brain integrity. GLIA 2014;62:233–246

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Rhombencephalitis Caused byListeria monocytogenesin Humans and Ruminants: A Zoonosis on the Rise?

Cited by 89 publications

References 324 publications

Listeria monocytogenes infection in ruminants: Is there a link to the environment, food and human health? A review

Listeria monocytogenes infection in ruminants: Is there a link to the environment, food and human health? A review

Encefalitis del tallo cerebral y mielitis por Listeria monocytogenes: caso clínico y revisión del tema

Dissociation of innate immune responses in microglia infected with Listeria monocytogenes

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