Rift <scp>V</scp>alley fever virus and <scp>E</scp>uropean mosquitoes: vector competence of Culex pipiens and Stegomyia albopicta (= Aedes albopictus)

Brustolin, Marco; Talavera, Sandra; Núñez, Ana Isabel; Santamaría, C. Berástegi; Rivas, Raquel; Pujol, Núria; Valle, Marta; Verdún, Marta; Brun, Alejandro; Pagès, Nonito; Busquets, Núria

doi:10.1111/mve.12254

Cited by 69 publications

(67 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that RVFV epidemics typically follow periods of heavy rainfall conducive to large mosquito populations (Davies, Linthicum, & James, 1985;Hassan, Ahlm, Sang, & Evander, 2011;Leedale, Jones, Caminade, & Morse, 2016;Redding, Tiedt, Lo Iacono, Bett, & Jones, 2017) as well as the trade and importation of infected animals into susceptible regions (Napp et al, 2018). In Africa, RVFV is mainly transmitted by the Aedes aegypti mosquito, however, a growing number of studies have made it clear that other mosquito species present in Asia, Europe and North/South America are experimentally competent as RVFV vectors (Brustolin et al, 2017;Ndiaye et al, 2016;Turell et al, 2015). Therefore, if RVFV were to be introduced into other continents and their endemic mosquito populations, it could cause widespread epidemics and could seriously impact the health of human populations and economically important livestock herds.…”

Section: Introductionmentioning

confidence: 99%

RVFV Infection in Goats by Different Routes of Inoculation

Kroeker

Smid

Embury-Hyatt

et al. 2018

Preprint

View full text Add to dashboard Cite

Rift Valley Fever virus (RVFV) is a zoonotic arbovirus of the Phenuiviridae family. Infection causes abortions in pregnant animals, high mortality in neonate animals and mild to severe symptoms in both people and animals. There is currently an ongoing effort to produce safe and efficacious veterinary vaccines against RVFV in livestock to protect against both primary infection in animals and zoonotic infections in people. To test the efficacy of these vaccines it is essential to have a reliable challenge model in relevant target species, including ruminants. We evaluated two goats breeds (Nubian and LaMancha), three routes of inoculation (intranasal, mosquito-primed subcutaneous and subcutaneous) using an infectious dose of 107 pfu/ml, a virus strain from the 2006-07 Kenyan/Sudan outbreak and compared the effect of using virus stocks produced in either mammalian or mosquito cells. Our results demonstrated that Nubian goats achieved the highest levels and longer duration of viremia. In the Nubian goats, all three routes of inoculation were equally efficient at producing clinical signs, consistent viremia (peak viremia: 1.2x103 - 1.0x105 pfu/ml serum), nasal and oral shedding of viral RNA (1.5x101 – 8x106 genome copies/swab), a systemic infection of tissues, and robust antibody responses. The Nubian goat breed and a needle-free intranasal inoculation technique could both be utilized in future vaccine and challenge studies.

show abstract

Section: Introductionmentioning

confidence: 99%

RVFV Infection in Goats by Different Routes of Inoculation

Kroeker

Smid

Embury-Hyatt

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition, serological studies have suggested that RVFV may be circulating in Turkey (71) and Iran (72). To date there has been no evidence of RVFV introduction into Europe, although some researchers have speculated that this is likely based on previous examples of translocation out of Africa and a number of studies have shown that mosquito species in Europe are competent vectors for the virus (12,73). With the possible exception of human travel from Africa, it seems unlikely that RVFV could be introduced inadvertently in livestock or livestock products to the UK due to paucity of such trade at the current time.…”

Section: Rift Valley Fevermentioning

confidence: 99%

Emerging Threats to Animals in the United Kingdom by Arthropod-Borne Diseases

et al. 2020

View full text Add to dashboard Cite

Worldwide, arthropod-borne disease transmission represents one of the greatest threats to public and animal health. For the British Isles, an island group on the northwestern coast of continental Europe consisting of the United Kingdom (UK) and the Republic of Ireland, physical separation offers a barrier to the introduction of many of the pathogens that affect animals on the rest of the continent. Added to this are strict biosecurity rules at ports of entry and the depauperate vector biodiversity found on the islands. Nevertheless, there are some indigenous arthropod-borne pathogens that cause sporadic outbreaks, such as the tick-borne louping ill virus, found almost exclusively in the British Isles, and a range of piroplasmid infections that are poorly characterized. These provide an ongoing source of infection whose emergence can be unpredictable. In addition, the risk remains for future introductions of both exotic vectors and the pathogens they harbor, and can transmit. Current factors that are driving the increases of both disease transmission and the risk of emergence include marked changes to the climate in the British Isles that have increased summer and winter temperatures, and extended the period over which arthropods are active. There have also been dramatic increases in the distribution of mosquito-borne diseases, such as West Nile and Usutu viruses in mainland Europe that are making the introduction of these pathogens through bird migration increasingly feasible. In addition, the establishment of midge-borne bluetongue virus in the near continent has increased the risk of wind-borne introduction of infected midges and the inadvertent importation of infected cattle. Arguably the greatest risk is associated with the continual increase in the movement of people, pets and trade into the UK. This, in particular, is driving the introduction of invasive arthropod species that either bring disease-causing pathogens, or are known competent vectors, that increase the risk of disease transmission if introduced. The following review documents the current pathogen threats to animals transmitted by mosquitoes, ticks and midges. This includes both indigenous and exotic pathogens to the UK. In the case of exotic pathogens, the pathway and risk of introduction are also discussed.

show abstract

“…In terms of vector competence, European Cx. pipiens hybrid forms have been shown to be able to transmit WNV [101] and RVFV [102].…”

Section: Culex Pipiens Biotype Molestus Forskal 1775mentioning

confidence: 99%

“…Ae. albopictus is a competent vector to 26 arboviruses in laboratory conditions [125] including WNV [101] and RVFV [102]. It has also been found infected with USUV in the field [126].…”

Section: Aedes (Stegomyia) Albopictus (Skuse1895)mentioning

confidence: 99%

West Nile virus and other mosquito-borne viruses present in Eastern Europe

Napp

Petrić

Busquets

2018

Pathogens and Global Health

View full text Add to dashboard Cite

Eastern Europe (EE) has been severely affected by mosquito-borne viruses (moboviruses). In this review, we summarize the epidemiology of moboviruses, with particular attention to West Nile virus (WNV). The study of WNV human cases in EE between 2010 and 2016, revealed that the epidemiology of WNV in EE is complex with the combination of introduction of different WNV strains from lineages 1 and 2, and the establishment of endemic cycles. We found a positive correlation between the risk of WNV re-emergence in an area and the number of human cases reported in the previous year. We also report the main ecological and biological characteristics of the key mosquito species vectors of moboviruses. Recent expansion of invasive mosquito species in EE, mainly Aedes albopictus but also Aedes aegypti and Culex quinquefasciatus, may result in new scenarios with an increased risk of transmission of moboviruses. Main gaps of knowledge in relation to moboviruses and their vectors in EE are identified. Understanding the epidemiology of moboviruses in EE is essential for the improvement of their surveillance and the control of the diseases they cause.

show abstract

Rift Valley fever virus and European mosquitoes: vector competence of Culex pipiens and Stegomyia albopicta (= Aedes albopictus)

Cited by 69 publications

References 60 publications

RVFV Infection in Goats by Different Routes of Inoculation

RVFV Infection in Goats by Different Routes of Inoculation

Emerging Threats to Animals in the United Kingdom by Arthropod-Borne Diseases

West Nile virus and other mosquito-borne viruses present in Eastern Europe

Contact Info

Product

Resources

About