Right ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?

Borgdorff, M. A. J.; Dickinson, Michael G.; Berger, Rudolphus; Bartelds, Beatrijs

doi:10.1007/s10741-015-9479-6

Cited by 58 publications

(75 citation statements)

References 115 publications

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“…In many experimental studies in the literature, data interpretation is hampered by the lack of RV pressure-volume analysis (Borgdorff et al 2015a), which remains the gold standard to assess the RV response to pressure overload (Vogel, 2008;Chesler et al 2009;Spruijt et al 2014;Voelkel et al 2015). Indeed, the use of pressure-volume analysis as means of load-independent contractility measurement has for a long time been restricted to the LV, because RV anatomy complicates accurate conductance signal acquisition.…”

Section: Discussionmentioning

confidence: 99%

Maintained right ventricular pressure overload induces ventricular–arterial decoupling in mice

Böehm

Lawrie

Wilhelm

et al. 2017

Experimental Physiology

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This is the peer reviewed version of the following article: Boehm, M. et al (2016), Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice. Exp Physiol., which has been published in final form at https://doi.org/10.1113/EP085963. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.This is an Accepted Article that has been peer-reviewed and approved for publication in the Experimental Physiology, but has yet to undergo copy-editing and proof correction. Please cite this article as an Accepted Article; doi: 10.1113/EP085963. This article is protected by copyright. All rights reserved. AbstractNew Findings: What is the central question of this study?The aim is to investigate whether complementary assessment of non-invasive ultrasound imaging along with closed chest-derived intra-cardiac pressure-volume catheterization is applicable to mice for an in-depth characterization of right ventricular (RV) function even upon maintained pressure overload. What is the main finding and its importance?Characterization

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Section: Discussionmentioning

confidence: 99%

Maintained right ventricular pressure overload induces ventricular–arterial decoupling in mice

Böehm

Lawrie

Wilhelm

et al. 2017

Experimental Physiology

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“…Moreover, PAH is also associated with long-term functional, structural and geometrical changes in the RV 5 . These changes and their impacts on ventricular mechanics are currently not well-understood 6 . Although animal models have been used to understand ventricular mechanics associated with RV remodeling in PAH 7,8 , similar studies in humans are lacking and most clinical investigations have been confined to quantifying global ventricular mechanics through pressure-volume (PV) loop measurements 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Patient-Specific Computational Analysis of Ventricular Mechanics in Pulmonary Arterial Hypertension

Chen

Latnie

Zhao

et al. 2016

Journal of Biomechanical Engineering

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Patient-specific biventricular computational models associated with a normal subject and a pulmonary arterial hypertension (PAH) patient were developed to investigate the disease effects on ventricular mechanics. These models were developed using geometry reconstructed from magnetic resonance (MR) images, and constitutive descriptors of passive and active mechanics in cardiac tissues. Model parameter values associated with ventricular mechanical properties and myofiber architecture were obtained by fitting the models with measured pressure-volume loops and circumferential strain calculated from MR images using a hyperelastic warping method. Results show that the peak right ventricle (RV) pressure was substantially higher in the PAH patient (65 mmHg versus 20 mmHg), who also has a significantly reduced ejection fraction (EF) in both ventricles (left ventricle (LV): 39% versus 66% and RV: 18% versus 64%). Peak systolic circumferential strain was comparatively lower in both the left ventricle (LV) and RV free wall (RVFW) of the PAH patient (LV: -6.8% versus -13.2% and RVFW: -2.1% versus -9.4%). Passive stiffness, contractility, and myofiber stress in the PAH patient were all found to be substantially increased in both ventricles, whereas septum wall in the PAH patient possessed a smaller curvature than that in the LV free wall. Simulations using the PAH model revealed an approximately linear relationship between the septum curvature and the transseptal pressure gradient at both early-diastole and end-systole. These findings suggest that PAH can induce LV remodeling, and septum curvature measurements may be useful in quantifying transseptal pressure gradient in PAH patients.

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“…Additionally, the vasodilatory response during Stress was more prominent in the RCA (44%) than in the LCA (39%). These microcirculatory events suggest that the calibrated CMCM LPN could describe the capillary density inadequacy in patients with RV hypertrophy [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Patient-specific modeling of right coronary circulation vulnerability post-liver transplant in Alagille’s syndrome

et al. 2018

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ObjectivesCardiac output (CO) response to dobutamine can identify Alagille's syndrome (ALGS) patients at higher risk of cardiovascular complications during liver transplantation. We propose a novel patient-specific computational methodology to estimate the coronary autoregulatory responses during different hemodynamic conditions, including those experienced in a post-reperfusion syndrome (PRS), to aid cardiac risk-assessment.Material and methodsData (pressure, flow, strain and ventricular volumes) from a 6-year-old ALGS patient undergoing catheter/dobutamine stress MRI (DSMRI) were used to parameterize a closed-loop coupled-multidomain (3D-0D) approach consisting of image-derived vascular models of pulmonary and systemic circulations and a series of 0D-lumped parameter networks (LPN) of the heart chambers and the distal arterial and venous circulations. A coronary microcirculation control model (CMCM) was designed to adjust the coronary resistance to match coronary blood flow (and thus oxygen delivery) with MVO2 requirements during Rest, Stress and a virtual PRS condition.ResultsIn all three simulated conditions, diastolic dominated right coronary artery (RCA) flow was observed, due to high right ventricle (RV) afterload. Despite a measured 45% increase in CO, impaired coronary flow reserve (CFR) (~1.4) at Stress was estimated by the CMCM. During modeled PRS, a marked vasodilatory response was insufficient to match RV myocardial oxygen requirements. Such exhaustion of the RCA autoregulatory response was not anticipated by the DSMRI study.ConclusionImpaired CFR undetected by DSMRI resulted in predicted myocardial ischemia in a computational model of PRS. This computational framework may identify ALGS patients at higher risk of complications during liver transplantation due to impaired coronary microvascular responses.

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Right ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?

Cited by 58 publications

References 115 publications

Maintained right ventricular pressure overload induces ventricular–arterial decoupling in mice

Maintained right ventricular pressure overload induces ventricular–arterial decoupling in mice

Patient-Specific Computational Analysis of Ventricular Mechanics in Pulmonary Arterial Hypertension

Patient-specific modeling of right coronary circulation vulnerability post-liver transplant in Alagille’s syndrome

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