Ring A-seco limonoids and flavonoids from the Kenyan Vepris uguenensis Engl. and their antioxidant activity

Kiplimo, Joyce Jepkorir; Islam, Shahidul; Koorbanally, Neil A.

doi:10.1016/j.phytochem.2012.06.025

Cited by 16 publications

(10 citation statements)

References 28 publications

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“…Compounds 44 to 49 showed moderate activity against the chloroquine-sensitive HB3 and the chloroquine-resistant K-1 strains of P. falciparum , with respective anti-plasmodial IC 50 values of 14.7, 9.3, 59.0, 53.0, and 56.9 μM [ 72 ]. Compound 50 (maculosidine), derived from Vepris uguenensis (Rutaceae), exhibited anti-malarial activities at 13.8 and 40.4 μg mL -1 against the 3D7 (chloroquine susceptible, CQS) and FCM29 (chloroquine resistant, CQR) strains of P. falciparum , respectively [ 73 ].…”

Section: Introductionmentioning

confidence: 99%

The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids

Ntie‐Kang

Onguéné

Lifongo

et al. 2013

Malar J

166

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Traditional medicine caters for about 80% of the health care needs of many rural populations around the world, especially in developing countries. In addition, plant-derived compounds have played key roles in drug discovery. Malaria is currently a public health concern in many countries in the world due to factors such as chemotherapy faced by resistance, poor hygienic conditions, poorly managed vector control programmes and no approved vaccines. In this review, an attempt has been made to assess the value of African medicinal plants for drug discovery by discussing the anti-malarial virtue of the derived phytochemicals that have been tested by in vitro and in vivo assays. This survey was focused on pure compounds derived from African flora which have exhibited anti-malarial properties with activities ranging from “very active” to “weakly active”. However, only the compounds which showed anti-malarial activities from “very active” to “moderately active” are discussed in this review. The activity of 278 compounds, mainly alkaloids, terpenoids, flavonoids, coumarines, phenolics, polyacetylenes, xanthones, quinones, steroids, and lignans have been discussed. The first part of this review series covers the activity of 171 compounds belonging to the alkaloid and terpenoid classes. Data available in the literature indicated that African flora hold an enormous potential for the development of phytomedicines for malaria.

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Section: Introductionmentioning

confidence: 99%

The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids

Ntie‐Kang

Onguéné

Lifongo

et al. 2013

Malar J

166

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“…Our compound has antioxidant properties similar to uguenenprenol and 7-O-methylaromadenrin against removal of the hydroxyl radical in vitro. On the other hand, compounds 11a and the elemodiol furoquinoline skimmianine alkaloids demonstrated lower antioxidant capacity at all concentrations tested in vitro (Kiplimo et al, 2012).…”

Section: Discussionmentioning

confidence: 86%

Phytochemical Profile and Qualification of Biological Activity of an Isolated Fraction of Bellis perennis

et al. 2013

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This study describes the isolation and identifi cation of apigenin-7-O-glucopyranoside, a fl avonoid isolated from the fl owers of Bellis perennis L., Asteraceae, an species with a broad spectrum of biological activities. The in vitro antioxidant activity and the inhibition of the enzyme acetylcholinesterase were evaluated. The fl avonoid showed strong in vitro antioxidant potential, because of the capacity of removal of hydroxyl radicals and nitric oxide, and also prevented the formation of thiobarbituric acid-reactive substances. These parameters were inhibited at the highest concentration of ApG at rates of 77.7%, 72% and 73.4%, respectively, in addition to inhibiting acetylcholinesterase, suggesting potential use in the treatment of neurodegenerative diseases.

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“…The DPPH free radical scavenging activity was evaluated according to the method followed by Kamble et al [27]. The hydroxyl radical scavenging activity was done according to the method described by Kiplimo et al [28].…”

Section: Antioxidant Activity Assaysmentioning

confidence: 99%

Characterization of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg Roots and their effects on antioxidant activity and H2O2-induced oxidative damage in RAW 264.7 cells

Huang

Khudoyberdiev

et al. 2021

BMC Chemistry

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This work presents an investigation on the composition and structure of polysaccharides from the roots of Tetrastigma hemsleyanum (THP) and its associated antioxidant activity. It further explores the protective effect of THP on RAW264.7 cells against cytotoxicity induced by H2O2. Ion chromatography (IC) revealed that THP contained glucose, arabinose, mannose, glucuronic acid, galactose and galacturonic acid, in different molar ratios. Furthermore, gel permeation chromatography-refractive index-multiangle laser light scattering (GPC-RI-MALS) was employed to deduce the relative molecular mass (Mw) of the polysaccharide, which was 177.1 ± 1.8 kDa. Fourier transform infrared spectroscopy (FT-IR) and Congo red binding assay highlighted that the THP had a steady α-triple helix conformation. Similarly, assays of antioxidant activity disclosed that THP had reasonable concentration-dependent hydroxyl radical and superoxide radical scavenging activities, peroxidation inhibition ability and ferrous ion chelating potency, in addition to a significant 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity. Moreover, THP could protect RAW264.7 cells against H2O2-induced cytotoxicity by decreasing intracellular ROS levels, reducing catalase (CAT) and superoxide dismutase (SOD) activities, increasing lactate dehydrogenase (LDH) activity and increment in malondialdehyde (MDA) level. Data retrieved from the in vitro models explicitly established the antioxidant capability of polysaccharides from T. hemsleyanum root extracts.

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Ring A-seco limonoids and flavonoids from the Kenyan Vepris uguenensis Engl. and their antioxidant activity

Cited by 16 publications

References 28 publications

The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids

The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids

Phytochemical Profile and Qualification of Biological Activity of an Isolated Fraction of Bellis perennis

Characterization of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg Roots and their effects on antioxidant activity and H2O2-induced oxidative damage in RAW 264.7 cells

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