Risk and efficacy of human‐enabled interspecific hybridization for climate‐change adaptation: response to Hamilton and Miller (2016)

Kovach, Ryan P.; Luikart, Gordon; Lowe, Winsor H.; Boyer, Matthew; Muhlfeld, Clint C.

doi:10.1111/cobi.12678

Cited by 26 publications

(26 citation statements)

References 32 publications

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“…However, we think this is a fruitful field for further research, given (a) the accumulating evidence for adaptation through aneuploidy (Selmecki et al, ; Yona et al, ), (b) the evidence that hybrid meiosis leads to high rates of aneuploidy in yeast (Rogers et al, ), and (c) the circumstance that both aneuploidy and hybridisation occur in stressful and perturbed habitats (Garroway et al, ; Muhlfeld et al, ). Whether hybridisation will generally assist or hamper adaptation to changing environments, with or without aneuploidy, is itself a debated topic (Hamilton & Miller, ; Kovach, Luikart, Lowe, Boyer, & Muhlfeld, ; Miller & Hamilton, ). In pathogenic microbes, this has particular relevance due to the medical risk of new hybrid pathogens emerging through genetic exchange with potentially increased virulence, larger host ranges, or increased drug resistance (Ochman, Lawrence, & Groisman, ).…”

Section: Discussionmentioning

confidence: 99%

“…Whether hybridisation will generally assist or hamper adaptation to changing environments, with or without aneuploidy, is itself a debated topic Kovach, Luikart, Lowe, Boyer, & Muhlfeld, 2016;. In pathogenic microbes, this has particular relevance due to the medical risk of new hybrid pathogens emerging through genetic exchange with potentially increased virulence, larger host ranges, or increased drug resistance (Ochman, Lawrence, & Groisman, 2000).…”

Section: Figurementioning

confidence: 99%

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Aneuploidy in yeast: Segregation error or adaptation mechanism?

Gilchrist

Stelkens

2019

Yeast

104

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Aneuploidy is the loss or gain of chromosomes within a genome. It is often detrimental and has been associated with cell death and genetic disorders. However, aneuploidy can also be beneficial and provide a quick solution through changes in gene dosage when cells face environmental stress. Here, we review the prevalence of aneuploidy in Saccharomyces, Candida, and Cryptococcus yeasts (and their hybrid offspring) and analyse associations with chromosome size and specific stressors. We discuss how aneuploidy, a segregation error, may in fact provide a natural route for the diversification of microbes and enable important evolutionary innovations given the right ecological circumstances, such as the colonisation of new environments or the transition from commensal to pathogenic lifestyle. We also draw attention to a largely unstudied cross link between hybridisation and aneuploidy. Hybrid meiosis, involving two divergent genomes, can lead to drastically increased rates of aneuploidy in the offspring due to antirecombination and chromosomal missegregation. Because hybridisation and aneuploidy have both been shown to increase with environmental stress, we believe it important and timely to start exploring the evolutionary significance of their co‐occurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Aneuploidy in yeast: Segregation error or adaptation mechanism?

Gilchrist

Stelkens

2019

Yeast

104

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“…Increasing the adaptability of the species would demand the careful consideration of novel but controversial genetic restoration approaches such as facilitated adaptation, genome editing, or assisted adaptive introgression [56, 57]. Although the evidence for recent natural introgression could encourage the use of Eurasian lynx as a source for the latter, such drastic measure should require the careful evaluation of hybrid fitness and the associated risks of maladaptation and hybrid swarm [58]. In any case, existing examples of species with long-term persistence and widespread distribution despite depleted genetic diversity [59] allow for some measure of hope and argue for the maintenance of current conservation efforts.…”

Section: Discussionmentioning

confidence: 99%

Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx

et al. 2016

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BackgroundGenomic studies of endangered species provide insights into their evolution and demographic history, reveal patterns of genomic erosion that might limit their viability, and offer tools for their effective conservation. The Iberian lynx (Lynx pardinus) is the most endangered felid and a unique example of a species on the brink of extinction.ResultsWe generate the first annotated draft of the Iberian lynx genome and carry out genome-based analyses of lynx demography, evolution, and population genetics. We identify a series of severe population bottlenecks in the history of the Iberian lynx that predate its known demographic decline during the 20th century and have greatly impacted its genome evolution. We observe drastically reduced rates of weak-to-strong substitutions associated with GC-biased gene conversion and increased rates of fixation of transposable elements. We also find multiple signatures of genetic erosion in the two remnant Iberian lynx populations, including a high frequency of potentially deleterious variants and substitutions, as well as the lowest genome-wide genetic diversity reported so far in any species.ConclusionsThe genomic features observed in the Iberian lynx genome may hamper short- and long-term viability through reduced fitness and adaptive potential. The knowledge and resources developed in this study will boost the research on felid evolution and conservation genomics and will benefit the ongoing conservation and management of this emblematic species.Electronic supplementary materialThe online version of this article (doi:10.1186/s13059-016-1090-1) contains supplementary material, which is available to authorized users.

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“…One of the reasons for this is that maintenance of species’ evolutionary potential via genetic rescue may have opposing effects in species of conservation concern (Kovach, Luikart, Lowe, Boyer, & Muhlfeld, 2016; Miller & Hamilton, 2016). On the one hand, the introduction of novel variation may limit demographic and genetic consequences of limited population size, providing the necessary variation to adapt to changing conditions (Carlson et al., 2014; Hufbauer et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Genetic conservation and management of the California endemic, Torrey pine (Pinus torreyanaParry): Implications of genetic rescue in a genetically depauperate species

Hamilton

Royauté

Wright

et al. 2017

Ecology and Evolution

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Rare species present a challenge under changing environmental conditions as the genetic consequences of rarity may limit species ability to adapt to environmental change. To evaluate the evolutionary potential of a rare species, we assessed variation in traits important to plant fitness using multigenerational common garden experiments. Torrey pine, Pinus torreyana Parry, is one of the rarest pines in the world, restricted to one mainland and one island population. Morphological differentiation between island and mainland populations suggests adaptation to local environments may have contributed to trait variation. The distribution of phenotypic variances within the common garden suggests distinct population‐specific growth trajectories underlay genetic differences, with the island population exhibiting substantially reduced genetic variance for growth relative to the mainland population. Furthermore, F1 hybrids, representing a cross between mainland and island trees, exhibit increased height accumulation and fecundity relative to mainland and island parents. This may indicate genetic rescue via intraspecific hybridization could provide the necessary genetic variation to persist in environments modified as a result of climate change. Long‐term common garden experiments, such as these, provide invaluable resources to assess the distribution of genetic variance that may inform conservation strategies to preserve evolutionary potential of rare species, including genetic rescue.

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Risk and efficacy of human‐enabled interspecific hybridization for climate‐change adaptation: response to Hamilton and Miller (2016)

Cited by 26 publications

References 32 publications

Aneuploidy in yeast: Segregation error or adaptation mechanism?

Aneuploidy in yeast: Segregation error or adaptation mechanism?

Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx

Genetic conservation and management of the California endemic, Torrey pine (Pinus torreyanaParry): Implications of genetic rescue in a genetically depauperate species

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