Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampin‐based regimen

Neogi, Devdatta Suhas; Yadav, Chandra Shekhar; Madhuri, Phani

doi:10.1080/17453670710015418

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…We also found that use of RIF combinations was associated with improved outcome of staphylococcal PVGI when compared to other antibiotic regimens, consistent with results of previous studies on other device-related infections such as those linked to orthopedic devices [20,36,37] and prosthetic valvular endocarditis [17,38]. Use of RIF combinations in these infections is supported by its intense and rapid bactericidal activity against staphylococci, its ability to penetrate into the biofilm and its persistent activity against microorganisms in stationary growth phase that are present at the surface of infected implants, including vascular grafts [13-16].…”

Section: Discussionsupporting

confidence: 90%

Factors predictive of treatment failure in staphylococcal prosthetic vascular graft infections: a prospective observational cohort study: impact of rifampin

et al. 2014

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BackgroundThere exists considerable debate concerning management of prosthetic vascular graft infection (PVGI), especially in terms of antimicrobial treatment. This report studies factors associated with treatment failure in a cohort of patients with staphylococcal PVGI, along with the impact of rifampin (RIF).MethodsAll data on patients with PVGI between 2006 and 2010 were reviewed. Cure was defined as the absence of evidence of infection during the entire post-treatment follow-up for a minimum of one year. Failure was defined as any other outcome.Results84 patients (72 M/12 F, median age 64.5 ± 11 y) with diabetes mellitus (n = 25), obesity (n = 48), coronary artery disease (n = 48), renal failure (n = 24) or COPD (n = 22) were treated for PVGI (median follow-up was 470 ± 469 d). PVGI was primarily intracavitary (n = 47). Staphylococcus aureus (n = 65; including 17 methicillin-resistant S. aureus) and coagulase-negative Staphylocococcus (n = 22) were identified. Surgical treatment was performed in 71 patients. In univariate analysis, significant risk factors associated with failure were renal failure (p = 0.04), aortic aneurysm (p = 0.03), fever (p = 0.009), aneurysm disruption (p = 0.02), septic shock in the peri-operative period (p = 0.005) and antibiotic treatment containing RIF (p = 0.03). In multivariate analysis, 2 variables were independently associated with failure:septic shock [OR 4.98: CI 95% 1.45-16.99; p=0.01] and antibiotic containing rifampin [OR: 0.32: CI95% 0.10-0.96; p=0.04].ConclusionResults of the present study suggest that fever, septic shock and non-use of antibiotic treatment containing RIF are associated with poor outcome.

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Section: Discussionsupporting

confidence: 90%

Factors predictive of treatment failure in staphylococcal prosthetic vascular graft infections: a prospective observational cohort study: impact of rifampin

et al. 2014

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“…Additionally, an influence of the substrate bias voltage on the wettability was determined. This could be related to a change in content of sp 3 and sp 2 hybridization in the a-C:H matrix [77,87]. The low wettability of the a-C:H:Cu layers is critical in terms of their biocompatibility, but beneficial to their antibacterial properties.…”

Section: Discussionmentioning

confidence: 99%

“…Upon closer examination of the coatings deposited with and without applying a substrate bias voltage in Figure 6, the coatings deposited with a substrate bias voltage had a slightly reduced contact angle. This can be attributed to an increase in the sp 3 -content in the a-C:H matrix. With high amounts of X Cu > 70%, no significant difference in contact angle with applied substrate bias was observed [(p = 0.204) > (α = 0.05)].…”

Section: Contact Anglementioning

confidence: 99%

“…Early infections can occur up to 90 days after operation and are usually acquired during the surgical procedure or as a result of implant-associated infections (peri-implantitis) [1]. Infection rates range between 0.3% and 1.7% after primary total hip replacement [2][3][4] and approximately 0.8% to 1.9% after primary total knee replacement [2,5,6]. When focusing on screw implants in orthodontics, the average success rate of dental mini-and microimplants is 84-88% according to various meta-analyses of clinical trials [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Surface Characterization and Copper Release of a-C:H:Cu Coatings for Medical Applications

et al. 2019

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This paper focuses on the surface properties of a-C:H:Cu composite coatings for medical devices and how the release of Cu2+ ions from such coatings can be controlled. The released Cu ions have the potential to act as a bactericidal agent and inhibit bacterial colonization. A PVD–PECVD hybrid process was used to deposit a-C:H:Cu composite coatings onto Ti6Al4V substrates. We examine the layer surface properties using atomic force microscopy and static contact angle measurements. An increasing surface roughness and increasing contact angle of Ringer’s solution was measured with increasing copper mole fraction (XCu) in the coatings. The contact angle decreased when a supplementary bias voltage of −50 V was used during the a-C:H:Cu deposition. These findings are in line with earlier published results regarding these types of coatings. The release of Cu2+ ions from a-C:H:Cu coatings in Ringer’s solution was measured by anodic stripping voltammetry. Different layer structures were examined to control the time-resolved Cu release. It was found that the Cu release depends on the overall XCu in the a-C:H:Cu coatings and that an additional a-C:H barrier layer on top of the a-C:H:Cu layer effectively delays the release of Cu ions.

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“…However, the reported success rate of debridement with prosthesis retention and long-term antibiotics is highly variable and has a wide range 8 9 10) . The reported rate of eradication varies from 21-89% 32 33) , but also in very recent ones, success rate 92.8% has been reported 24 34) .…”

Section: Main Subjectsmentioning

confidence: 95%

Management of Periprosthetic Hip Joint Infection

2015

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Total hip joint replacement offers dramatic improvement in the quality of life but periprosthetic joint infection (PJI) is the most devastating complication of this procedure. The infection threatens the function of the joint, the preservation of the limb, and occasionally even the life of the patient due to long term hospitalization and high cost. For the surgeon it is a disastrous burden, which requires repeated, complicated procedures to eradicate infection and to provide a mobile joint without pain. Yet in the absence of a true gold standard, the diagnosis of PJI can be elusive. Synovial fluid aspiration, diagnostic imaging, traditional culture, peripheral serum inflammatory markers, and intraoperative frozen sections each have their limitations but continue to be the mainstay for diagnosis of PJI. Treatment options mainly include thorough irrigation and debridement with prosthesis retention, or a two-stage prosthesis exchange with intervening placement of an antibiotic-loaded spacer. Success in treating PJI depends on extensive surgical debridement and adequate and effective antibiotic therapy. Treatment in two stages using a spacer is recommended for most chronic PJI. Debridement, antibiotics and implant retention is the obvious choice for treatment of acute PJI, with good success rates in selected patients. This article presents an overview of recent management concepts for PJI of the hip emphasizing diagnosis and the clinical approach, and also share own experience at our institution.

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Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampin‐based regimen

Cited by 8 publications

References 18 publications

Factors predictive of treatment failure in staphylococcal prosthetic vascular graft infections: a prospective observational cohort study: impact of rifampin

Factors predictive of treatment failure in staphylococcal prosthetic vascular graft infections: a prospective observational cohort study: impact of rifampin

Surface Characterization and Copper Release of a-C:H:Cu Coatings for Medical Applications

Management of Periprosthetic Hip Joint Infection

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