Risk factors for asthma among children in Maputo (Mozambique)

Mavale‐Manuel, S.; Alexandre, Fernanda Antunes; Duarte, N.P.; Albuquerque, Olga Maria Ramalho de; Scheinmann, P.; Poisson-Salomon, A.-S.; Blic, J. de

doi:10.1046/j.1398-9995.2003.00333.x

Cited by 20 publications

(16 citation statements)

References 33 publications

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“…This is in conformity with many previous studies that have demonstrated an association between maternal asthma and development of childhood asthma and further emphasizes the important role of genetic susceptibility in development of asthma [5,20]. The precise mechanism for this is not clearly understood, but several workers have postulated that multiple genes are involved in pathogenesis of asthma such as; production of allergen-specific Immunoglobulin E(IgE), expression of broncho hyper-responsiveness, generation of inflammatory mediators such as cytokines and chemokines, and modulation of Th2 response to antigens [25-27].…”

Section: Discussionsupporting

confidence: 92%

“…In Africa, the majority of studies on childhood asthma were carried out among children aged 7-14 years [1-4]. Although evidence suggests that asthma starts in infancy, few researchers have studied risk factors for asthma in young children [5]. Hitherto, factors associated with asthma among children less than five years have not been established in Uganda.…”

Section: Introductionmentioning

confidence: 99%

“…In Africa, studies have revealed factors associated with asthma that can guide clinicians in asthma case detection and management [2,5]. In these studies, childhood asthma has been associated with genetic factors such as a family history of asthma and allergy as well as male gender.…”

Section: Introductionmentioning

confidence: 99%

“…In these studies, childhood asthma has been associated with genetic factors such as a family history of asthma and allergy as well as male gender. Environmental factors such as in-door and out-door allergens, air pollution, second hand smoking and respiratory tract infections have also been linked to childhood asthma [5-7]. Most of these studies were in developed countries, yet, asthma phenotypes and, the role and extent of the factors associated with asthma differ in developed and low-income countries [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with asthma among under-fives in Mulago hospital, Kampala Uganda: a cross sectional study

et al. 2013

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BackgroundAsthma is the most common chronic childhood illness, with rapidly increasing prevalence in low-income countries. Among young children, asthma is often under-diagnosed.We investigated the factors associated with asthma among under-fives presenting with acute respiratory symptoms at Mulago hospital, Uganda.MethodsA hospital-based cross sectional study of 614 children with cough and/or difficult breathing, and fast breathing, was conducted between August 2011 and June 2012. A questionnaire focusing on clinical history of the child was administered to the caretakers. A physical examination and, laboratory and radiological investigations were done. Asthma was defined according to GINA (Global Initiative for Asthma) guidelines which were modified by excluding the symptom of “chest tightness”, spirometry/peak expiratory flow measurements and by adding chest x-ray findings to distinguish asthma from pneumonia. A panel of three paediatricians reviewed the participants’ case reports and, guided by the study definitions, made a diagnosis of asthma or other. Multivariable logistic regression analysis was done to determine factors independently associated with asthma.ResultsOf the 614 children, 128 (20.8%) had asthma, 125 (20.4%) bronchiolitis, 167 (27.2%) bacterial pneumonia only, 163 (26.5%) viral pneumonia while 31 (5.1%) had other diagnoses including pulmonary tuberculosis. The majority (71.1%) of children with asthma were aged ≥ 12 months. Factors associated with asthma included maternal asthma (AOR 2.4, 95% CI 1.2, 4.6), a history of allergy in the patient (AOR 2.6, 95% CI 1.2, 5.4,), use of gas for cooking (AOR 3.8, 95% CI 1.2, 13.3), prematurity (AOR 9.3, 95% CI 1.2, 83.3) and high level of education of caretaker (AOR 9.1, 95% CI 1.1, 72.8).ConclusionMaternal asthma, a history of allergy in the patient, use of gas for cooking, prematurity and high level of education of caretaker were significantly associated with asthma. There is need for studies to explore the role of the above factors in development and exacerbation of childhood asthma to provide information that can be used to design strategies for asthma prevention and control.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors associated with asthma among under-fives in Mulago hospital, Kampala Uganda: a cross sectional study

et al. 2013

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“…However, another study by the same group, carried out in Maputo and involving 100 asthmatic children and 99 nonasthmatic children aged between 18 months and 8 years (mean age of around 3 years for both groups), showed that having been born or living in inner Maputo were independent and significant risk factors for bronchial asthma 59. Curiously, another South African study suggested that urban–rural differences in the prevalence of atopy may be partly due to differences in dietary components in the 2 areas 60…”

Section: Modifiers Of Expression Of Allergic Diseases In Southern Africamentioning

confidence: 96%

Socio-epidemiological Aspects of Respiratory Allergic Diseases in Southern Africa

Taborda-Barata

Potter

2012

World Allergy Organization Journal

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The prevalence of respiratory allergic diseases has been increasing in Southern Africa both in urban and in rural environments. Various factors may contribute toward this situation, namely, exposure to aeroallergens, such as grass pollens and house dust mites. However, other irritant environmental triggers, such as exposure to tobacco smoke and certain indoor and outdoor fumes, may also play a relevant part. Furthermore, certain parasitic and mycobacterial infections may act as allergic disease risk modifiers, although such an influence should be confirmed. Finally, certain cultural and socioeconomic factors may also influence accessibility to healthcare and adherence to treatment of these diseases.

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Allergic rhinitis and non‐allergic rhinitis in children in the tropics: Prevalence and risk associations

Chiang

Chen

Tan

et al. 2012

Pediatric Pulmonology

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Risk factors for asthma among children in Maputo (Mozambique)

Abstract: Childhood asthma was strongly associated with a family history of asthma and rhinitis, the place of residence, having smokers as parents and early weaning from maternal breast milk. These results highlight the need to reassess the management of asthmatic children in Maputo.

Cited by 20 publications

References 33 publications

Factors associated with asthma among under-fives in Mulago hospital, Kampala Uganda: a cross sectional study

Factors associated with asthma among under-fives in Mulago hospital, Kampala Uganda: a cross sectional study

Socio-epidemiological Aspects of Respiratory Allergic Diseases in Southern Africa

Allergic rhinitis and non‐allergic rhinitis in children in the tropics: Prevalence and risk associations

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