Risk factors for bronchiolitis, recurrent wheezing, and related hospitalization in preterm infants during the first year of life

Pérez-Yarza, Eduardo González; Moreno‐Galdó, Antonio; Ramilo, Octavio; Rubí, Teresa; Escribano, Amparo; Torres, A. De Castro; Sardón, Olaia; Oliva, Concepción; Pérez, Guadalupe; Cortell, Isidoro; Rovira‐Amigo, Sandra; Pastor-Vivero, Maria Dolores; Pérez‐Frías, Javier; Velasco, Valle; Torres-Borrego, J.; Figuerola, Joan; Barrio, María Isabel; García‐Hernández, Gloria; Mejías, Asunción

doi:10.1111/pai.12414

Cited by 30 publications

(24 citation statements)

References 33 publications

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“…Fifteen pediatric hospitals in Spain participated in the study (Table ). Interim results for the first year have been previously reported, and the complete data for the study including the second and third years are included in the present report. The study protocol was approved by the Ethics Committees, and all the procedures followed the principles outlined in the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Recurrent wheezing during the first 3 years of life in a birth cohort of moderate‐to‐late preterm infants

Moreno‐Galdó

Pérez-Yarza

Ramilo

et al. 2019

Pediatric Allergy Immunology

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Section: Methodsmentioning

confidence: 99%

Recurrent wheezing during the first 3 years of life in a birth cohort of moderate‐to‐late preterm infants

Moreno‐Galdó

Pérez-Yarza

Ramilo

et al. 2019

Pediatric Allergy Immunology

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“…More recent analysis from a large population based, data-linkage study reported a 12% increase in the overall frequency of infection-related hospitalisation during childhood for each week reduction in gestational age [6]. In addition to reduced gestational age, low birth weight, although at least partly inter-dependent with gestational age, has also been attributed to a 19% increase in the proportion of infants hospitalised with acute respiratory infection for each 500 g reduction in birth weight [6,41]. …”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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“…Infants colonized with Clostridium difficile were found to be at higher risk for developing eczema, recurrent wheeze, and allergic sensation, while Escherichia coli was associated with eczema (Penders et al, ). Low birth weight is one of the risks for development of both bronchiolitis and asthma in the first year of life (Perez‐Yarza et al, ). In a study of 432 children with parental history of atopy, the odds ratio for development of asthma in those children born by Cesarean was 2.1 (Pistiner et al, ).…”

Section: Part IImentioning

confidence: 99%

The very low birth weight infant microbiome and childhood health

Groër

Gregory

Louis‐Jacques

et al. 2015

Birth Defects Research Pt C

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This review describes current understandings about the nature of the very low birth weight infant (VLBW) gut microbiome. VLBW infants often experience disruptive pregnancies and births, and prenatal factors can influence the maturity of the gut and immune system, and disturb microbial balance and succession. Many VLBWs experience rapid vaginal or Caesarean births. After birth these infants often have delays in enteral feeding, and many receive little or no mother's own milk. Furthermore the stressors of neonatal life in the hospital environment, common use of antibiotics, invasive procedures and maternal separation can contribute to dysbiosis. These infants experience gastrointestinal dysfunction, sepsis, transfusions, necrotizing enterocolitis, oxygen toxicity, and other pathophysiological conditions that affect the normal microbiota. The skin is susceptible to dysbiosis, due to its fragility and contact with NICU organisms. Dysbiosis in early life may resolve but little is known about the timing of the development of the signature gut microbiome in VLBWs. Dysbiosis has been associated with a number of physical and behavioral problems, including autism spectrum disorders, allergy and asthma, gastrointestinal disease, obesity, depression, and anxiety. Dysbiosis may be prevented or ameliorated in part by prenatal care, breast milk feeding, skin to skin contact, use of antibiotics only when necessary, and vigilance during infancy and early childhood.

show abstract

Risk factors for bronchiolitis, recurrent wheezing, and related hospitalization in preterm infants during the first year of life

Cited by 30 publications

References 33 publications

Recurrent wheezing during the first 3 years of life in a birth cohort of moderate‐to‐late preterm infants

Recurrent wheezing during the first 3 years of life in a birth cohort of moderate‐to‐late preterm infants

The impact of respiratory viruses on lung health after preterm birth

The very low birth weight infant microbiome and childhood health

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