Risk Factors for Cancer in Renal Transplant Recipients1

Danpanich, Ekachai; Kasiske, Bertram L.

doi:10.1097/00007890-199912270-00008

Cited by 113 publications

(71 citation statements)

References 20 publications

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“…[9] Other risk factors attributable to development of malignancy in these patients is advancing age, viral infections, cigarette smoking, and transmission of malignancy from donor cells. [10] Thus, strict follow-up and vigilance for signs and symptoms of malignancy should be followed in patients with organ transplantation on immunosuppressive drugs, even after decades of transplant.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of tongue 18 years after renal transplantation: a case report

Poddar¹,

Sharma²,

Kunikullaya³

2016

JCMT

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Solid organ transplant recipients are at increased risk of developing malignancies, even decades after transplant, due to the prolonged use of immunosuppressant drugs. A 35-year-old male underwent renal transplant for end stage renal disease 18 years previously and was on immunosuppressive drugs since that time and was on regular follow up. In 2016, he developed a squamous cell carcinoma of tongue, which was operated and adjuvant radiation therapy was given. The patient is currently on follow up and asymptomatic. Though squamous cell carcinoma of tongue is a relatively common malignancy in the general population, it is very rare in transplant recipients. Hence, such patients require longer follow-up, active surveillance, and screening for early diagnosis and prompt treatment of premalignant and malignant conditions. Key words:Renal transplant, immunosuppression, carcinoma tongue ABSTRACTArticle history:

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Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of tongue 18 years after renal transplantation: a case report

Poddar¹,

Sharma²,

Kunikullaya³

2016

JCMT

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“…In another study conducted on 1334 renal transplant patients, it was shown that cancer incidence in patients who smoked increased compared with patients who did not smoke. 10,11 However, although it causes cardiovascular disease and cancer, smoking is not considered a con traindication for surgical procedures. 12 Because complete smoking history was insufficient in this study, cancer and cardiovascular diseases could not be assessed.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

Exp Clin Transplant

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Objectives: Smoking is the most important remediable risk factor for the progression of renal diseases. Smoking has serious adverse effects, such as cardiovascular disease, kidney function impairment, and cancer in kidney transplant recipients who are already at high risk for these diseases. In this study, our objective was to evaluate descriptive characteristics and smoking status of renal transplant recipients. Materials and Methods: We evaluated 113 patients who underwent renal transplant at Baskent University Hospital between 1990 and 2015. The medical records of all patients were retrospectively reviewed. Patient demographics, cause of renal diseases, mortality status, smoking status, and amount of smoking were recorded. Results: In our study, 82 patients (72.7%) were male and 31 were female. The mean age was 38.50 ± 12.94 years. Causes of renal failure were as follows: 15.9% from hypertension, 12.4% from diabetes mellitus (all types), 8% from glomerulonephritis, 8% from vesicoureteral reflux, 6.2% from polycystic kidney disease, 17.6% other, and 31.9% unknown. Comorbid systemic disease was found in 57.6% of the patients. Fifty patients (44.2%) were current smokers, and 63 patients (55.8%) were nonsmokers. Mean age of smokers was 44.68 ± 10.60 years, with most being male patients (92.0%). There was a statistically significant difference between smoking status and sex (P < .001). The presence of comorbid diseases was significantly different between smokers and nonsmokers (P = .001). The smoking status of patients with hypertension (28.2%) was significantly different (P = .032) than others. Conclusions:Smoking cessation is associated with substantial health benefits for all smokers. For kidney transplant recipients, cigarette smoking has many adverse effects, causing cardiovascular disease and other comorbid diseases. Therefore, every attempt should be made to encourage kidney transplant candidates to stop smoking. Key words: Renal diseases, Smoking, Transplantation IntroductionSmoking is the most important risk factor in the progression of the renal diseases that can be corrected. In chronic renal diseases, cutting down on smoking is the most important factor in decreasing kidney malfunction. 1 Renal transplant recipients have a higher death rate related to diseases of cardiovascular origin than healthy individuals. 2 Smoking itself can be the main reason for cardiovascular mortality in renal transplant patients. Although chronic smoking increases proteinuria, it decreases renal plasma flow. 3 Although many argue that the nephrotoxic effects of smoking also affect renal transplant recipients, studies are scarce regarding the relation between smoking history and smoking habits and the smoking behaviors of patients on renal transplant wait lists. 2 The effect of smoking on the lifespan of renal transplant recipients has been evaluated by a limited number of studies. Because of cardiovascular diseases due to smoking, transplant recipients who smoke have a shorter lifespan. It is known that smoking befor...

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“…This is likely attributed to a combination of risk factors including those common to the general population and the overall immunosuppression burden. Indeed, genetic predisposition and history of pre-transplant malignancy are independent risk factors for the development of malignancy [16]. Patients with a history of invasive cancer before transplantation were found to have more than double the risk of post-transplant cancer compared with patients with no history of malignancy [14].…”

Section: Discussionmentioning

confidence: 99%

De novo papillary carcinoma in a renal allograft: the pros and cons of immunosuppression

2015

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We present a case of a multifocal kidney transplant renal cell carcinoma in a 35-year-old lady, presenting 16 years after kidney transplantation, diagnosed during investigation of recurrent urinary tract infections. The patient underwent a graft nephrectomy and subsequently maintained on haemodialysis. She remained disease-free after 4 years of surveillance and thus reactivated on the transplant list. This case reinforces the fact that immunosuppressive therapy has made kidney transplantation possible; however, it is accompanied by a higher incidence of malignancy. It also reinforces the importance of lifelong screening of both native and renal transplant grafts.

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Risk Factors for Cancer in Renal Transplant Recipients1

Cited by 113 publications

References 20 publications

Squamous cell carcinoma of tongue 18 years after renal transplantation: a case report

Squamous cell carcinoma of tongue 18 years after renal transplantation: a case report

Untitled

De novo papillary carcinoma in a renal allograft: the pros and cons of immunosuppression

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