Risk factors for extended-spectrum b-lactamases-producing Escherichia coli urinary tract infections in a tertiary hospital

Alcántar‐Curiel, María Dolores; Alpuche-Aranda, Celia; Varona-Bobadilla, Héctor Javier; Gayosso-Vázquez, Catalina; Jarillo-Quijada, Ma Dolores; Frías-Mendivil, Mauricio; Sanjuan-Padrón, Lucio; Santos-Preciado, José Ignacio

doi:10.21149/spm.v57i5.7621

Cited by 15 publications

(15 citation statements)

References 31 publications

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“…The ESBL producer E. coli was implicated in community and hospital acquired infection and thus limited the treatment options of the infections induced by such bacteria [26]. The extent of resistance rate that was demonstrated in this study of ESBL E. coli isolates was consistent with previous reports [26][27][28][29][30][31].…”

Section: Discussionsupporting

confidence: 90%

“…ESBL positive E. coli was with significantly higher resistance rate to tetracycline and aziteonam than ESBL negative isolates. ESBL positive E. coli isolates were higher resistant to cotrimoxazole than ESBL negative isolates and this was in line of previous studies [26,30,31,32,35,36,38]. The resistance rate was significantly higher in ESBL producer E. coli than that of negative isolates to ciprofloxacin, norfloxacin and nalidixic acid of the quinolone antibiotics group.…”

Section: Discussionsupporting

confidence: 90%

“…Antimicrobial resistance is a global health problem with worldwide clinical 14substantial burden and their rate increased with time [25]. ESBL producers bacterial isolates demonstrated higher resistance rate to antibiotics as compared to ESBL negative isolates [26][27][28][29][30][31]. Although the rate of resistance was higher in ESBL positive as compared to ESBL negative producers E. coli isolates for all tested antibiotics, however, the differences were significant for Amoxicillin-Clav and pipercillin from penicillin group, while the differences in susceptibility did not reach significant level for ampicillin and carbencillin.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Antibiotic Sensitivity between Extended Spectrum Beta Lactamase Producers and ESBL Negative Escherichia coli Clinical Isolates

Alsamarai¹,

Ali

2018

IJMS

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Background: Recurrent urinary tract infection [UTI] and treatment failure were common challenges in the control of UTI in Iraqi community. Objective: To determine the difference in antibiogram and multidrug resistance between ESBL positive and negative E. coli clinical isolates. Materials and methods: prospective cross-sectional study was conducted during the period from 1st of June 2015 to the end of January 2016. The study population was 563 women, of them 425 [75.5%] were outpatients, and 138 [24.5%] were inpatients. Their age range was between 18 and 80 years, with a mean age of 33.59±15.29 years. Urine samples were immediately cultured on blood agar and MacConkey agar by spread plate technique. Bacterial colonies with different morphology were selected, purified and identified according to their biochemical characteristics using conventional standard methods. Results: The rate of resistance was higher in ESBL positive as compared to ESBL negative producers E. coli isolates for all tested antibiotics. A high rate of resistance was demonstrated by most of the tested antibiotics. A low resistance rate in both ESBL positive and negative E. coli were demonstrated against amikacin, imipenem and nitrofurantoin. ESBL producer E. coli isolates were resistant to ≥5 of MDR in 98% of isolates [92/94], while the corresponding value was 71% [29/41], while MDR to ≥7 was 56% [53/94] in ESBL producer and 17% [7/41] in ESBL none producer E. coli. Conclusion: ESBL producing was of significant influence on the emergence of resistance in E. coli clinical isolates

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Comparison of Antibiotic Sensitivity between Extended Spectrum Beta Lactamase Producers and ESBL Negative Escherichia coli Clinical Isolates

Alsamarai¹,

Ali

2018

IJMS

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“…In Kulkarni et al study, in 2017, in the northeast of Carnataka, the highest infection was with Escherichia coli, with an increase in resistance to ampicillin up to 82.53% and an increase in sensitivity to imipenem up to (96.71%) (30). In the Alcántar study in 2015, Escherichia coli showed the highest resistance to cephalosporin and showed the highest susceptibility to carbapenem and amikacin (29), which is contradicted with the data from our study. The cause of creating different resistance and sensitivity patterns can be the unnecessary use of antibiotics and, consequently, drug resistance.…”

Section: Discussioncontrasting

confidence: 88%

Prevalence and pattern of antibiotic resistance of gram-negative bacteria isolated from urinary tract infections in patients referring to Neka laboratories-Iran

Zare¹,

Rostami²,

Shahsafi

2018

IJBMPH

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Introductionrinary tract infection is an inflammatory response of the urethra to the invasion of pathogenic microorganisms (1). This infection is of the highest importance after respiratory tract infection and is the second most common infection in children and adults and the most important infection in infants. In the world, every year, 150 million people are affected by this infection, and includes 35% of hospital infections (2-4). Urinary tract infections are one of the most common infections that occur at different ages and mis-treatment of it can lead to serious complications such as disorders of the urinary tract, hypertension, uremia and early delivery and even abortions in pregnant women. More than 50% of women get UTIs at least once in their lifetime. The severity of these infections depends on factors such as bacterial virulence. The risk factors for urinary tract infection include host characteristics, host behavior, and bacterial characteristics. Sexual activity and contraceptive methods are also important risk factors for the development of symptomatic urinary tract infection. Cell receptor characteristics, anatomy differences and host genetics are risk factors for recurrence of infection (5-6). Urinary tract infections U

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“…In the current study the ESBL producing E. coli was resistant to ciprofloxacin (100%), levofloxacin (80%), gentamycin (100%),cefotaxime (100%), trimethoprim (60%), amikacin (40%), amoxicillinclavulanic acid (40%), tazobactum+pipracilline (20%), and meropenem(0%).The most potent antibiotic was meropenem (100%).Our study correlate with the previous study that isolated ESBL producing E. coli were highly resistant to ciprofloxacin (100%) and levofloxacin (100%) and the susceptible antibiotic was meropenem (100%) [25].…”

Section: Discussionsupporting

confidence: 87%

Prevalance of Extended Spectrum Beta Lactamases (ESBL) Producing Escherichia Coli Isolated From Clinical Samples at Tertiary Care Hospital Peshawar

2017

AIDT

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Escherichia coli is Gram negative, facultative and non sporulating rod shaped bacteria. It is commonly inhabitant of the gastrointestinal tract of humans and animals. E. coli cause diseases like urinary tract infection cholecystitis, cholangitis and traveler’s diarrhoea and the UTI which is more prevalent worldwide. E. coli cause complication like Hemolytic Uremic Syndrome which leads to renal failure, Thrombotic Thrombocytopenic Purpura, septicemia and peritonitis. Extend spectrum beta lactamase enzyme produce by E. coli which capable of hydrolyzing first and third generation cephalosporin, and is inhibited by beta lactamase inhibitor. A total of 150 clinical samples (blood, urine, wound swab, body fluids) were collected from Post Graduate Lady Reading Hospital Peshawar. Different media used were Nutrient agar, MacConky agar and Cysteine, Lactose and Electrolyte-Deficient agar. E. coligive pink colonies on MacConky agar because it is lactose fermenter. For further confirmation different biochemical tests were performed like triple sugar iron, Indole, and citrate utilization tests. The antibiotics susceptibility and resistivity was checked by disk diffusion method and different antibiotics were used. For ESBL detection combined disk method was performed. In the clinical samples the percentage of Gram positive bacteria in blood was (20%), urine (14.2%), wound swab (83.3%), and body fluids (8%), and the Gram negative in urine was (80%), blood (7%), wound swab (10%), and body fluids (0%). E. coli was more prevalent in urine which was 25(35.71%) and ESBL producing E. coli was 5(20%). The ESBL producing E. coli was resistant to ciprofloxacin (100%), amikacin (40%), amoxicillin+clavulanic acid (40%), levofloxacin (80%), tazobactum+pipracilline (20%), gentamycin (100%), trimethoprim (60%), cefotaxime (100%) and meropenem (0%). Sensitivity toward levofloxacin (20%), tazobactum+pipracilline (80%), gentamycin (0%), trimethoprim (40%), cefotaxime (0%) and meropenem (100%), ciprofloxacin (0%), amikacin (60%), amoxicillin+clavulanic acid (60%). The most effective antibiotic against ESBL producing E. coli was Meropenem while least effective antibiotics against ESBL producing E. coli were Gentamycin and Ciprofloxacin.

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Risk factors for extended-spectrum b-lactamases-producing Escherichia coli urinary tract infections in a tertiary hospital

Cited by 15 publications

References 31 publications

Comparison of Antibiotic Sensitivity between Extended Spectrum Beta Lactamase Producers and ESBL Negative Escherichia coli Clinical Isolates

Comparison of Antibiotic Sensitivity between Extended Spectrum Beta Lactamase Producers and ESBL Negative Escherichia coli Clinical Isolates

Prevalence and pattern of antibiotic resistance of gram-negative bacteria isolated from urinary tract infections in patients referring to Neka laboratories-Iran

Prevalance of Extended Spectrum Beta Lactamases (ESBL) Producing Escherichia Coli Isolated From Clinical Samples at Tertiary Care Hospital Peshawar

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