Risk Factors for Juvenile Dermatomyositis: Exposure to Tobacco and Air Pollutants During Pregnancy

Abstract

Objective. To evaluate the influence of exposure to inhaled environmental factors during pregnancy on the diagnosis of juvenile dermatomyositis (DM).Methods. We performed a case-control study comprising 20 juvenile DM patients and 56 healthy controls matched by age and sex who were residents in the metropolitan region of a large city. A questionnaire assessed demographic data and environmental inhalation exposure during pregnancy (occupational exposure to demolition, chalk, construction and/or quarry dust, paints, varnish, gasoline vapor, and/or battery fluids; stationary sources of inhaled pollution near the mother's home; and maternal tobacco exposure). Daily concentrations of inhaled particulate matter, SO 2 , NO 2 , O 3 , and carbon monoxide (CO) were evaluated throughout the gestational period. Results. Maternal occupational exposure to school chalk dust/gasoline vapor in the juvenile DM group was significantly higher compared with controls (50% versus 4.6%; P ‫؍‬ 0.001). Smoking mothers and secondhand smoke exposure at home during pregnancy were significantly higher in the juvenile DM group versus controls (smoking mothers: 20% versus 1.7%; P ‫؍‬ 0.01, and secondhand smoke: 35% versus 19%; P ‫؍‬ 0.07). In univariate logistic regression models, maternal smoking, occupational exposure to inhaled agents, and the highest tertile of tropospheric CO (3.2-5.4 parts per million) in the third trimester were significantly associated with juvenile DM (P < 0.05). In the multivariate analysis, smoking mother (odds ratio [

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Poluentes atmosféricos associados ao peso insuficiente ao nascimento

“…Many studies found associations between pollution and birth weight [24][25][26][27][28] . Medeiros et al 22 observed in their study that the maternal exposure in the first pregnancy trimester to air pollution may contribute to lower gain of weight of the child at birth.…”

Geospatial Correlation of Amyopathic Dermatomyositis With Fixed Sources of Airborne Pollution: A Retrospective Cohort Study

“…Important contributors include point sources, which denote emissions from larger, stationary industrial and commercial facilities, on-road sources, produced by vehicles on roads, and secondary sources, which are formed from the chemical reactions of other emitted pollutants (22). Since DM has been associated with airborne pollutants, this dataset may be useful in analyzing exposure patterns (11–13).…”