Risk factors for new-onset diabetes mellitus after living donor kidney transplantation in Korea - a retrospective single center study

Abstract

BackgroundNew-onset diabetes mellitus after transplantation (NODAT) is a serious complication following renal transplantation. The aim of this study was to identify the risk factors for the development of NODAT in Korean transplant patients.MethodsRecipients who underwent living donor kidney transplantation between January 2009 and April 2012 at Asan Medical Center were reviewed. Diagnosis of NODAT was defined according to the American Diabetes Association criteria.ResultsA total of 418 patients were enrolled. NODAT was diagnosed in 85 (20.4 %) patients within 1 year. By multivariate analysis, old age (odds ratio [OR], 1.05; 95 % Confidence interval [CI]: 1.01–1.08), family history of diabetes mellitus (OR, 2.48; 95 % CI: 1.04–5.94), pre-transplant high serum glucose level (OR, 1.04; 95 % CI: 1.01–1.08), and obesity (OR, 3.46; 95 % CI: 1.55–7.73) were independent risk factors for NODAT.ConclusionOld age, family history of diabetes, pre-transplant high plasma glucose level, and obesity are independent factors associated with the development of diabetes after renal transplantation. In contrast, serum magnesium levels and the use of tacrolimus are not associated with the development of NODAT.Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-016-0321-8) contains supplementary material, which is available to authorized users.

Risk factors for new-onset diabetes mellitus after kidney transplantation (NODAT): a Brazilian single center study

“…N ew-onset diabetes after transplant, or NODAT, is one of the major complications after solid organ transplantation (1,2). There is a five-to six-fold higher incidence of new-onset diabetes mellitus (DM) in the first year post kidney transplantation in comparison to waiting-listed patients (3).…”

Effects of preoperative hepatitis B virus infection, hepatitis C virus infection, and coinfection on the development of new‐onset diabetes after kidney transplantation

“…Moreover, incident NODAT directly imposes an extra financial burden on KTRs . Several risk factors for NODAT have been identified thus far, including advanced recipient age, a family history of diabetes, obesity, elevated preoperative fasting plasma glucose (FPG), and chronic exposure to immunosuppressants …”

“…5 Several risk factors for NODAT have been identified thus far, including advanced recipient age, a family history of diabetes, obesity, elevated preoperative fasting plasma glucose (FPG), and chronic exposure to immunosuppressants. 6,7 In recent years, considerable attention has been paid to hepatitis viruses, especially hepatitis B virus (HBV) and hepatitis C virus (HCV), as well as their extrahepatic effects on glucose metabolism. Results from the non-transplant population suggested a notable association between HCV infection and diabetes, [8][9][10] but the association between HBV infection and diabetes remained controversial.…”

The Effect of Posttransplantation Diabetes Mellitus on the Prognosis of Transplantation: a Prospective Cohort Study

“…In recent years, several studies have reported the incidence of PTDM, which was defined by the 2009 KDIGO criteria. In the USA [8] , the incidence of PTDM was reported as 11%, and in Japan [9] and Korea [10] , it was 11.3% and 20.4%, respectively. The prevalence rate in our study, including patients who all came from China, was similar to that in other countries, especially the east Asian countries.…”