Risk factors for the incidence and progression of radiographic osteoarthritis of the knee among Japanese

Nishimura, Akinobu; Hasegawa, Masahiro; Kato, Ko; Yamada, Tomomi; Uchida, Atsushi; Sudo, Akihiro

doi:10.1007/s00264-010-1073-x

Cited by 69 publications

(77 citation statements)

References 21 publications

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“…It is interesting, then, to consider that females are well recognised as particularly susceptible to OA [19]. Evidence-based medicine has shown that OA prevalence and incidence are generally higher in females [22,23]. Taken together, these findings suggest that the presence of apelin may contribute to differences in the incidence of OA in males and females.…”

Section: Discussionmentioning

confidence: 86%

Increased apelin serum levels and expression in human chondrocytes in osteoarthritic patients

Tang

Chen

et al. 2010

International Orthopaedics (SICOT)

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Apelin is a recently discovered hormone secreted by adipocytes. The aim of this study, therefore, was to evaluate the distribution of apelin in paired serum and synovial fluid (SF) of osteoarthritis (OA) patients, as compared to that in healthy controls, and to characterise the expression profile of apelin and its cognate receptor APJ in human chondrocytes. Apelin levels in serum and SF were analysed by enzyme-linked immunosorbent assay (ELISA). Expression of apelin and APJ in human chondrocytes was determined by real-time quantitative polymerase chain reaction (PCR). Apelin was found to be present in OA SF, and concentrations were positively correlated with the severity of OA. OA serum exhibited significantly elevated levels of apelin (2.18±0.22 ng/ml) as compared to normal serum (1.31±0.12 ng/ml) (p<0.05), and serum apelin levels exceeded those in paired SF (p < 0.001). The apelin and APJ transcripts were identified in chondrocytes, and levels were significantly higher in OA cartilage than in healthy donors. These findings suggest that apelin may contribute to the onset and/or progression of OA, and may provide new insights into the pathophysiology of OA.

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Section: Discussionmentioning

confidence: 86%

Increased apelin serum levels and expression in human chondrocytes in osteoarthritic patients

Tang

Chen

et al. 2010

International Orthopaedics (SICOT)

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“…10 Female sex, age, and BMI are well-known risk factors for OA, as shown in previous studies. [24][25][26][27][28] Also, in the literature, a low level of education was found to be a significant factor associated with OA. 29,30 Hochman et al 10 compared age, sex, and educational level in knee OA patients between those who used NP descriptors and who did not use NP descriptors.…”

Section: Discussionmentioning

confidence: 99%

Is There a Possible Neuropathic Pain Component in Knee Osteoarthritis?

et al. 2017

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Objectives: This study aims to investigate the neuropathic pain (NP) component in patients with osteoarthritis (OA) of the knee and its association with physical function, risk factors, and stages of OA. Patients and methods: A total of 109 patients (16 males, 93 females; mean age 62.5±8.5 years; range 44 to 81 years) diagnosed with knee OA according to the American College of Rheumatology criteria were enrolled in this study between July 2014 and June 2015. Patients were evaluated with visual analog scale for pain severity, PainDETECT questionnaire for presence and severity of neuropathic pain, Western Ontario and McMaster Universities osteoarthritis index for physical function, and the Kellgren-Lawrence system for severity of OA. Presence of the associated risk factors were also questioned. Results: A total of 12 patients (11%) were classified as having likely NP and 23 patients (21.1%) were classified as having possible NP. PainDETECT scores were significantly correlated with the visual analog scale scores and Western Ontario and McMaster Universities osteoarthritis index pain, physical function and total scores. Patients with neuropathic pain had significantly longer symptom duration than the patients without NP. However, we found no relationship between the other risk factors and NP. Conclusion: This study demonstrated that some of the knee OA patients had a NP component as the underlying cause of knee pain. Patients with NP had longer symptom duration, increased severity of pain, and disability. Therefore, the presence of NP component in these patients should be considered. Once it is determined, appropriate intervention strategies for NP should be incorporated in the routine treatment modalities of knee OA.

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“…Osteoarthritis (OA) is a multivariate degenerative disease of synovial joints resulting from both mechanical and biological factors, among which sex, age, genetic factors, trauma and obesity play the most important role [1]. The influence of obesity on the development of OA was recognised either in respect to the mechanical load leading to increased feasibility of damage of the joint structures [2], or as a result of activation of mechanoreceptors on cartilage surface, which in turn can lead to the synthesis of the inflammatory mediators [3].…”

Section: Introductionmentioning

confidence: 99%

Correlations between serum adipocytokine concentrations, disease stage, radiological status and total body fat content in the patients with primary knee osteoarthritis

Richter

Trzeciak

Rybka

et al. 2016

International Orthopaedics (SICOT)

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Purpose The study was designed to investigate whether serum concentrations of leptin, resistin and adiponectin in obese and normal-weight patients with primary knee osteoarthritis (OA) correlate with clinical and radiological stages of the disease and percentage of total body fat. Methods Seventy-three patients with knee OA, divided into obese and normal-weight groups, were clinically evaluated according to the Knee Society Score (KSS), and radiologically assessed using Kellgren and Lawrence scale. The percentage of total body fat and some anthropometric data were also given. Serum leptin, resistin and adiponectin concentrations were measured by Elisa and were correlated with the clinical, radiological and anthropometric parameters. Results Leptin concentrations were significantly higher (p = 0.001) in the obese patients and positively correlated (R = 0.63) with radiologically assessed OA grade, but only in the normal-weight group. Resistin and adiponectin concentrations were identical in obese and normal-weight patients and negatively correlated (R = −0.41) with the clinical status of obese patients. In both groups, percentage of total body fat positively correlated (R = 0.29 and R = 0.53 for obese and normal-weight respectively) with radiologically assessed OA grade. However, no correlations were found with clinical status of the patients. Conclusions It was found that in the obese patients with knee OA, increased percentage of total body fat and elevated serum leptin concentration might favour the advancement of clinical but not radiologically assessed changes in the joint structures, while in normal-weight patients it correlates only with radiologically assessed changes but does not affect to an appreciable extent the clinical status of the patients.

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Risk factors for the incidence and progression of radiographic osteoarthritis of the knee among Japanese

Cited by 69 publications

References 21 publications

Increased apelin serum levels and expression in human chondrocytes in osteoarthritic patients

Increased apelin serum levels and expression in human chondrocytes in osteoarthritic patients

Is There a Possible Neuropathic Pain Component in Knee Osteoarthritis?

Correlations between serum adipocytokine concentrations, disease stage, radiological status and total body fat content in the patients with primary knee osteoarthritis

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