Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay

Kim, Si-Ho; Oh, Suhyun; Nham, Eliel; Ko, Jeong‐Hun; Huh, Kyungmin; Cho, Sun Young; Kang, Cheol-In; Chung, Doo Ryeon; Choi, Gyu‐Seong; Kim, Jong Man; Peck, Kyong Ran

doi:10.1016/j.ijid.2021.10.043

Cited by 2 publications

(4 citation statements)

References 25 publications

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“…Prophylaxis with isoniazid is well tolerated even in patients with end-stage liver disorders and in those who have received liver transplants. Kim, 2021 11 Republic of Korea Cross sectional study…”

Section: Resultsmentioning

confidence: 99%

“…Kim, et al (2021) 11 conducted a study with twenty-one patients and showed out of a total of 717 eligible LT recipients who were included in this study acquired active TB. After transplantation, the incidence rates of tuberculosis were as follows: 2,261, 724, and 119 cases/100,000 person-years in the first, second, and less than third years, respectively.…”

Section: Transplant Recipientsmentioning

confidence: 99%

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Tuberculosis in Liver Transplant Recipient : a Systematic Review

Amelia¹

2023

JARMHS

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Background: Despite claims, transplant recipients' TB rates are random. The rate of posttransplant tuberculosis depends on the organ transplanted, pre-transplant latent tuberculosis screening, and previous antituberculosis medication. This rate may also depend on recipient and donor tuberculosis rates. Active tuberculosis after solid organ transplantation increases the risk of graft loss and death four-fold compared to the general population. Aim: This article examines the link between tubercolis and liver transplant recipient. Methods: This study showed that it met all of the requirements by looking at the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 guidelines. So, the experts could make sure that the study was as current as possible. The search method used a number of electronic reference databases, such as Pubmed and SagePub, to look for papers that were published between 2000 and 2023. We didn't look at review papers, articles that had already been published, or articles that were only half done. Result: In the PubMed database, the results of our search brought up 66 articles, whereas the results of our search on SagePub brought up 23 articles. The results of the search conducted for the last year of 2013 yielded a total of 23 articles for PubMed and 18 articles for SagePub. In the end, we compiled a total of 20 papers, 16 of which came from PubMed and four of which came from SagePub. We included five research that met the criteria. Conclusion: Patients who have undergone organ transplantation are at high risk of developing latent TB. This shows the importance of administering prophylactic drugs such as isoniazid in post-liver transplant patients.

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Section: Resultsmentioning

confidence: 99%

Section: Transplant Recipientsmentioning

confidence: 99%

Tuberculosis in Liver Transplant Recipient : a Systematic Review

Amelia¹

2023

JARMHS

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“…The studies encompassed 2 prospective cohort studies [ 16 , 17 ], 2 retrospective cohort studies [ 18 , 19 ], 8 cross-sectional studies [ 20–27 ], and 3 case-control studies [ 8 , 28 , 29 ], describing cytomegalovirus infection to subsequent risk of tuberculosis disease ( Table 1 ). Seven studies reported a dose-response relationship between cytomegalovirus load values or cytomegalovirus antibody levels and risk of active tuberculosis [ 16 , 20–23 , 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…The studies were carried out from 1990 to 2021 with sample sizes ranging from 65 to 30 433 participants. Of these, 6 were undertaken in countries with a high burden of multidrug-resistant tuberculosis [ 8 , 16 , 20 , 24 , 27 , 29 ], 6 in high tuberculosis burden countries [ 19 , 21–23 , 26 , 28 ], 1 in an intermediate tuberculosis burden country [ 18 ], and 2 in low tuberculosis burden countries [ 17 , 25 ]. All studies reported significant association between cytomegalovirus infection and the development of tuberculosis disease, except for 1 study [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Association Between Cytomegalovirus Infection and Tuberculosis Disease: A Systematic Review and Meta-Analysis of Epidemiological Studies

Kua

Chongmelaxme

Lee

2022

The Journal of Infectious Diseases

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Background Tuberculosis is one of the leading causes of mortality worldwide from an infectious disease. This review aimed to investigate the association between prior cytomegalovirus infection and tuberculosis disease. Methods Six bibliographic databases were searched from their respective inception to December 31, 2021. Data were pooled using random-effects meta-analysis. Results Of 5,476 identified articles, 15 satisfied the inclusion criteria with a total sample size of 38,618 patients. Pooled findings showed that individuals with cytomegalovirus infection had a higher risk of tuberculosis disease compared to those not infected with cytomegalovirus (OR: 3.20, 95% CI: 2.18 to 4.70). Age was the only covariate that exerted a significant effect on the result of the association. Meta-analysis of risk estimates reported in individual studies showed a marked and significant correlation of cytomegalovirus infection with active tuberculosis (Adjusted HR: 2.92, 95% CI: 1.34 to 4.51; Adjusted OR: 1.14, 95% CI: 0.71 to 1.57). A clear dose-response relation was inferred between the levels of cytomegalovirus antibodies and the risks of tuberculosis events (OR for high levels of cytomegalovirus antibodies: 4.07; OR for medium levels of cytomegalovirus antibodies: 3.58). Conclusions The results suggest an elevated risk of tuberculosis disease among individuals with a prior cytomegalovirus infection.

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Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay

Cited by 2 publications

References 25 publications

Tuberculosis in Liver Transplant Recipient : a Systematic Review

Tuberculosis in Liver Transplant Recipient : a Systematic Review

Association Between Cytomegalovirus Infection and Tuberculosis Disease: A Systematic Review and Meta-Analysis of Epidemiological Studies

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