Risk of breast cancer in women with non-lactational mastitis

Chang, Chin-Chun; Lin, Mei‐Chen; Yin, Weiqiang

doi:10.1038/s41598-019-52046-3

Cited by 18 publications

(15 citation statements)

References 39 publications

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“…In addition, women who had comorbidity, such as hyperlipidemia, had an increased risk of breast cancer. Our findings are consistent with previous studies [13,14]. In their 2009 cohort study, Lambe et al identified from their database 8411 women who had a diagnosis of mastitis.…”

Section: Discussionsupporting

confidence: 93%

“…When women with breast cancer were compared with those who had no recorded mastitis, the incidence rate of breast cancer was higher in women with mastitis [13]. Another study conducted by Chang et al identified that women with nonlactational mastitis faced a higher risk of breast cancer [14], which is similar to our results. In addition, our study focused on women aged ≥40.…”

Section: Discussionsupporting

confidence: 89%

“…Lambe et al showed that women who had a record of mastitis would be mildly more at risk of breast cancer [13]. Moreover, Chang et al reached a similar conclusion in their study with a population of adult women [14]. Furthermore, after conducting a systemic review, Nolan et al recently presented the hypothesis that mastitis might be a risk factor for breast cancer [15].…”

Section: Introductionmentioning

confidence: 90%

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Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

et al. 2020

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Background and objectives: Breast cancer is a common cancer in women and has been the fourth leading cause of death in Taiwanese women. Risk factors for breast cancer include family history of breast cancer, genetic factors, and not breastfeeding. Several studies have reported an association between repeated inflammation at a young age, especially among lactating women, and cancer; however, the number of studies about the association of mastitis and breast cancer in nonlactating women is still limited. Therefore, the aim of this study was to determine the relationship between mastitis in women aged ≥40 years and breast cancer. Materials and Methods: This was a retrospective cohort study design. The data source was the Longitudinal Health Insurance Database 2010 (LHID 2010), comprising data collected by Taiwan’s National Health Insurance program. Cases of newly diagnosed mastitis in women aged ≥40 years (ICD-9-CM code = 611.0) were selected from the years 2010 to 2012. Women not diagnosed with mastitis were selected as the control group, and their data for the years 2009 to 2013 were obtained through the database. In addition, the non-mastitis group was matched 1:10 by age. Results: A total of 8634 participants were selected from the LHID 2010, which included 734 cases with mastitis and 7900 cases without mastitis. After adjustment for age, hypertension, hyperlipidemia, diabetes, hypothyroidism, and autoimmune diseases, the Cox proportional hazard model showed that patients with mastitis had a higher risk of breast cancer (aHR = 3.71, 95% CI = 1.9–7.02) compared with the non-mastitis group. The Kaplan–Meier curve also showed that women with mastitis had a higher risk of developing breast cancer. Conclusions: This study confirmed that women with mastitis have a higher risk of developing breast cancer. Therefore, women aged ≥40 years could reduce breast cancer risk by taking precautions to prevent mammary gland infection and mastitis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 90%

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Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

et al. 2020

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Section: Methodsmentioning

confidence: 99%

“…The insurance premium was divided into 4 subgroups: 0 to 15 840 new Taiwan dollars (NTD) (equivalent to 0 to 528 United States dollars [USD]), 15 841 to 28 800 NTD (528 to 960 USD), 28 801 to 45 800 NTD (960 to 1526 USD), and >45 800 NTD (>1526 USD) per month 22 . We set 15 840 NTD as the low socioeconomic status cutoff point because it is the government‐regulated minimum salary specified for a full‐time worker in Taiwan 22 . The NHRI stratified all townships and city districts in Taiwan into 7 urbanization levels based on population density (people/km 2 ), population ratio of habitants with higher educational degree, elder older than 65 years, and agriculture and the number of physicians per 100 000 people.…”

Section: Methodsmentioning

confidence: 99%

Exploring the Relationship Between Colorectal Cancer and Allopurinol: A Taiwanese Population‐Based Propensity‐Matched Case‐Control Study

Hsu

Huang

Lin

et al. 2021

The Journal of Clinical Pharma

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The role of allopurinol usage in colorectal cancer (CRC) has no definite conclusion. The aim of this study was to explore the correlation between allopurinol usage and CRC risk in Taiwan. Using the National Health Insurance Database, we conducted a case‐control study of cases who were ≥20 years old and had newly diagnosed CRC for the period from 2000 to 2013. The controls were matched to cases by age, sex, index year, comorbidities, and socioeconomic status using propensity scores. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were measured by the conditional logistic regression model. We examined 4372 cases and 4372 matched controls. A statistically significant correlation was noted between allopurinol usage and CRC risk (OR, 0.79; 95%CI, 0.69‐0.90). We used the cumulative‐defined daily doses (cDDDs) in a further subgroup analysis, the ORs decreased from tertile 1 (T1; low dose, <12 cDDDs), T2 (medium dose, 12 to 88.5 cDDDs), to T3 (high dose, >88.5 cDDDs). These values were 0.85 (95%CI, 0.69‐1.06), 0.77 (95%CI, 0.62‐0.95), to 0.76 (95%CI, 0.61‐0.94). The results indicated a dose‐response relationship between allopurinol usage and CRC risk (P for trend < .001). We thus inferred that patients with medium and high doses of allopurinol (≥12 cDDDs) had a statistically significantly decreased CRC risk.

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Is there an association between mastitis and breast cancer? a retrospective cohort study from Germany

Krishnan,

Kostev,

Kalder

2024

Cancer Causes Control

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Purpose The aim of the study was to explore the association between mastitis and subsequent breast cancer. Methods This retrospective cohort study included women aged ≥ 18 years with an initial mastitis diagnosis from 315 office-based gynecologists in Germany between January 2005 and December 2021. Women without mastitis were matched to women with mastitis using propensity score matching based on age, index year, average yearly consultation frequency during the follow-up period, and coexisting diseases such as obesity, benign mammary dysplasia, hypertrophy of the breast, unspecified lump of breast, and other disorders of the breast. The 10-year cumulative incidence of breast cancer for the mastitis-cohort and non-mastitis-cohort was studied with Kaplan–Meier curves using the log-rank test. The association between mastitis and breast cancer was studied separately for four age groups with univariable Cox regression analyses. Results In the follow-up period of 7 months to 10 years after the index date, 2.9% of mastitis patients and 2.4% of matched non-mastitis patients were diagnosed with breast cancer. A Cox regression analysis revealed a significant association between mastitis and subsequent breast cancer (HR: 1.37; 95% CI: 1.11–1.70). According to the age-stratified analyses, a strong and significant association was only observed in the age group > 50 years (HR: 1.73; 95% 1.25–2.40). Conclusion The findings of our retrospective cohort study support an association between mastitis and subsequent breast cancer diagnoses in women aged > 50 years. The pathophysiological basis and possibility of confounders however requires further investigation.

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Risk of breast cancer in women with non-lactational mastitis

Cited by 18 publications

References 39 publications

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

Exploring the Relationship Between Colorectal Cancer and Allopurinol: A Taiwanese Population‐Based Propensity‐Matched Case‐Control Study

Is there an association between mastitis and breast cancer? a retrospective cohort study from Germany

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