Risk of coeliac disease in children of patients and effect of HLA genotype.

Dennis, N R; Stokes, Chris R.

doi:10.1136/jmg.15.1.20

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…The identity of the additional factor(s) involved is obscure, and could reflect either genetic or environmental influences. However, reports of identical twins concordant for DH [23] and several studies indicative of increased risk of DH and celiac disease in first-degree relatives [24][25][26] strongly support the involvement of one or more additional genes.…”

Section: Smentioning

confidence: 99%

Epidemiology and the Genetics of Psoriasis.

Rp²,

Jj³

1994

J Invest Dermatol

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Section: Smentioning

confidence: 99%

Epidemiology and the Genetics of Psoriasis.

Rp²,

Jj³

1994

J Invest Dermatol

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“…Numerous studies attest to the involvetnent of specific HLA alleles in psoriasis [19][20][21][22][23][24][25]. The serologically-defined class I antigens HLA-B13, B17, B39, B57, Cw6, and Cw7, and the class II antigens HLA-DR4 and DR7 all show increased association with psoriasis in population studies.…”

Section: Smentioning

confidence: 99%

“…In other words, each predisposing gene would need to be present in 50% of the population. Such a multigene model would seem a better fit for an uncommon, HLA-associated disease such as dermatitis herpetifortnis, in which the HLA association with DQw2 is virtually complete and yet only a very small fraction (less than 0.03%) of HLA-DQw2-positive individuals go on to develop disease [17][18][19]. In contrast, in psoriasis nearly 10% of HLA-Cw6-positive individuals develop psoriasis (Fig 1), suggestive of the involvement of only a limited number of independent genetic factors.…”

Section: How Many Genes?mentioning

confidence: 99%

Of Genes and Antigens: The Inheritance of Psoriasis.

Elder¹,

Henseler²,

Christophers³

et al. 1994

J Invest Dermatol

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Psoriasis is one of a number of autoimmune diseases that display significant HLA associations. In particular, individuals with onset of disease prior to 40 years of age display striking associations with HLA-Cw6 and are much more likely to have a positive family for psoriasis. However, only about 10% of Cw6-positive individuals develop disease, suggesting that other genetic and/or environmental factors must be involved. Several compelling lines of epidemiologic evidence indicate that psoriasis susceptibility is inherited, albeit not in a simple monogenic fashion, and that genetic, rather than environmental, factors are primarily responsible for the variability in inheritance of psoriasis. Taken together, these observations suggest that one or more loci in addition to HLA are necessary for the development of psoriasis. The number of additional loci is likely to be small, because i) the disease is very common ii) substantial excess risk of psoriasis is observed in first degree relatives, and iii) nevoid variants of psoriasis have been reported, suggestive of somatic mutation of a single gene during development. The substantial homogeneity of the psoriatic phenotype and the clear evidence for increased HLA association and heritability in juvenile onset disease indicate that despite its complexity, psoriasis is a common disease whose etiology is amendable to elucidation through the techniques of modern molecular genetics.

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“…Coeliac disease (CD) is familial, and most cases carry the HLA-Dw3 allele; 10% of subjects from the families affected by the disease have jejunal villous atrophy (Dennis and Stokes, 1978). Identical twins with CD whose genotype was homozygous HLA1-B8 are now reported.…”

Section: Introductionmentioning

confidence: 99%