Risk of premature luteinization in IVF cycles and its impact on clinical pregnancy rate

Choudhary, Manisha; Sharma, Sangita; Swarankar, M L; Bhardwaj, Shiv Lal

doi:10.18203/2320-6012.ijrms20160020

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…[17] As per the latest Indian study, PL (>1.5 ng/ml) was noticed in 16% cases in the agonist group and 6% in the antagonist group (p-0.002). [12] The overall incidence of PL in our study was 12.8% without any significant difference between agonist and antagonist protocol. A study by Houmard et al .…”

Section: Discussionmentioning

confidence: 62%

“…Many studies including a meta-analysis have shown that PL is associated with a decreased probability of pregnancy during IVF. [111213] On the contrary, some previous researchers did not find any significant differences in pregnancy rates during IVF with high- or low-progesterone levels on the day of ovulation trigger. [14] Two recent studies have shown that serum progesterone level on ovulation trigger day did not affect clinical pregnancy rate.…”

Section: Introductionmentioning

confidence: 92%

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Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome

Nagaraja¹,

Talwar²,

Mukherjee³

et al. 2019

J Hum Reprod Sci

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Background: Premature luteinization (PL) is defined as a premature rise in serum progesterone concentration on or before the day of ovulation trigger with human chorionic gonadotropin. The incidence of PL varies between 5% and 30% during in vitro fertilization and embryo transfer (IVF-ET). Materials and Methods: The prospective observational study comprising 380 patients undergoing IVF-ET. Blood samples were collected for serum progesterone level estimation on the day of ovulation trigger. Ovum pickup was done 36 h later and serum progesterone levels were correlated with IVF-ET outcome. Study Outcome: To correlate serum progesterone level on the day of ovulation trigger during IVF and its effect on treatment outcome. Results: Mean serum progesterone level in the positive pregnancy group and negative pregnancy group was 0.892 ± 0.752 ng/ml and 0.91 ± 0.688 ng/ml, respectively ( P = 0.961). The overall incidence of PL was 12.8% with 12.7% and 13.6% in the agonist and antagonist protocol respectively ( P = 0.9001). PL incidence was 13.5% and 13.4% in positive pregnancy and negative pregnancy group ( P = 0.223). Conclusion: PL has been associated with 12.8% of the IVF cycles. There was no statistically significant difference observed in the incidence of PL between different IVF stimulation protocols. PL does not seem to affect IVF outcome.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 92%

Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome

Nagaraja¹,

Talwar²,

Mukherjee³

et al. 2019

J Hum Reprod Sci

View full text Add to dashboard Cite

show abstract

“…8.3% and 6.8% respectively at p=0.117 (Venetis et al, 2015;Ecochard et al, 2013). Recently, studies on Indians about PL incidence amongagonist and antagonist subgroups were found to be in 16% cases only at p=0.02 level (Choudhary et al, 2016). An observed value of PL occurrence was 13.33% in studied groups but no significant difference was found among agonist and antagonist subgroups.…”

Section: Discussionmentioning

confidence: 80%

Association of raised serum progesterone level with ovulation trigger and histology of endometrium in stimulated cycles

Wang

Zhu

Gong

2022

Braz. J. Pharm. Sci.

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This was a forthcoming study of those patients, who undergo in-vitro fertilization (IVF) and freeze-all embryo, who acquiesce for the study. The number of participated patients (n=350) in this study, underwent for IVF. The blood sample was collected from patients to evaluate the level of serum progesterone in vacuum vials on the day of ovulation trigger. After 36 hrs of ovulation trigger, ovum picked up was done. Quantitative methods were used to estimate the level of serum progesterone through the electrochemiluminescence immunoassay and correlation of serum progesterone with embryo transfer (ET) outcomes. Main outcome of this current study was to evaluate the value of mean serum progesterone level i.e.0.868± 0.712 ng/ml and 0.88±0.723 ng/ml was found in case of pregnancy positive and negative respectively, at p=0.216 value. In antagonist (n=40) and agonist (n=310) cases, it was 8(20%) and 37(11.94%) PL occurrence was noted at p=0.143 respectively. An overall value of the premature lutenization (PL) occurrences was 13.63% and 15.25% observed in both positive and negative cases of pregnancy at p=0.216 respectively. This study concluded that 12.66% of PL occurrences were recorded in the case of IVF. Study results proved, there were no significant effect of PL on pregnancy outcomes.

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Risk of premature luteinization in IVF cycles and its impact on clinical pregnancy rate

Cited by 2 publications

References 24 publications

Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome

Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome

Association of raised serum progesterone level with ovulation trigger and histology of endometrium in stimulated cycles

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