Rituximab induces a transient fluctuation of peripheral and follicular helper T cells in neuromyelitis optica spectrum disorder

Huang, Zhenning; Liu, Ye; An, Xu; Zhang, Chen; Zhang, Tianxiang; Li, Huining; Feng, Bin; Li, Yanyan; Zhang, Chao

doi:10.1016/j.jneuroim.2023.578167

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Depletion of B cells with rituximab and inebilizumab was frequently used to prevent relapse. Rituximab was found to induce the fluctuation of Tfh and PD‐1 + CXCR5‐CD4 + T peripheral helper (Tph) cells, which can both contribute to plasma cell differentiation and antibody production (Huang et al., 2023 ). Tfh cells are essential for the differentiation of B cells to antibody‐secreting cells; moreover, Tfh cells were presumed to play an important role in autoantibodies generation and contributed to autoimmune diseases (Tangye et al., 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Duan,

Rui,

Yang

et al. 2024

Brain and Behavior

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BackgroundNeuromyelitis optica spectrum disorder (NMOSD) associated with cognitive impairment (CI) is acknowledged. However, the underlying pathogenesis and involvement of the immune system remain unclear.ObjectivesThis study aimed to investigate the alterations in immune cells, cytokines, and GABA+ levels in NMOSD patients with cognitive deficits.MethodsThirty‐eight NMOSD patients and 38 healthy controls (HCs) were included. NMOSD patients were stratified as NMOSD‐CI and NMOSD‐CP groups. The difference in cognitive functions, Tfh and cytokines, and GABA+ levels were assessed, and their correlations were calculated.ResultsNMOSD‐CI patients showed worse performance on all cognitive tests, and the percentage of circulating follicular helper T cells (cTfh) was significantly elevated. The frequency of cTfh was positively and negatively correlated with Stroop‐A and AVLT long‐delayed scores, respectively. IL‐21 was remarkably higher in NMOSD‐CI and NMOSD‐CP. The level of GABA+ in medial prefrontal cortex (mPFC) was significantly decreased in NMOSD‐CI and was proved positively and negatively correlated with Symbol Digit Modalities Test and the frequency of circulating Tfh cells, respectively.ConclusionIn NMOSD‐CI patients, all cognitive domains were impacted, , while GABA+ levels in mPFC were decreased. GABA+ levels in NMOSD‐CI were negatively correlated with the frequency of cTfh, suggesting the underlying coupling mechanism between immune responses and neurotransmitter metabolism in CI in NMOSD patients.

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Section: Discussionmentioning

confidence: 99%

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Duan,

Rui,

Yang

et al. 2024

Brain and Behavior

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Peripheral helper T cells in human diseases

Zou,

Huo,

Sun

et al. 2024

Journal of Autoimmunity

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Seronegative NMOSD patients display distinctive peripheral blood T-cell subset frequencies

Sanli,

Karaaslan,

Yilmaz

et al. 2024

Clinical and Experimental Immunology

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Rituximab induces a transient fluctuation of peripheral and follicular helper T cells in neuromyelitis optica spectrum disorder

Cited by 3 publications

References 39 publications

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Peripheral helper T cells in human diseases

Seronegative NMOSD patients display distinctive peripheral blood T-cell subset frequencies

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Rituximab induces a transient fluctuation of peripheral and follicular helper T cells in neuromyelitis optica spectrum disorder

Cited by 3 publications

References 39 publications

Correlation of GABA+ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Correlation of GABA+ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Peripheral helper T cells in human diseases

Seronegative NMOSD patients display distinctive peripheral blood T-cell subset frequencies

Contact Info

Product

Resources

About

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment

Correlation of GABA⁺ levels in the medial prefrontal cortex and circulating follicular helper T cells in neuromyelitis optica spectrum disorder patients with cognitive impairment