2021
DOI: 10.1016/j.ijbiomac.2021.01.154
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RNA binding protein PUM1 promotes colon cancer cell proliferation and migration

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Cited by 22 publications
(14 citation statements)
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“…Additionally, the function of CSN-5 in FBF stabilization may be relevant for understanding cancer as hCSN5 is upregulated in many human cancers (Lee et al, 2011; Liu et al, 2020). Similarly, a number of cancers overexpress PUM1 and/or PUM2 (Guan et al, 2018; Gor et al, 2021; Shi et al, 2021; Smialek et al, 2021). This PUM protein overexpression in cancer might be borne out through its stabilization via hCSN5 and therefore reflect an unappreciated mechanism promoting cancer cell proliferation.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, the function of CSN-5 in FBF stabilization may be relevant for understanding cancer as hCSN5 is upregulated in many human cancers (Lee et al, 2011; Liu et al, 2020). Similarly, a number of cancers overexpress PUM1 and/or PUM2 (Guan et al, 2018; Gor et al, 2021; Shi et al, 2021; Smialek et al, 2021). This PUM protein overexpression in cancer might be borne out through its stabilization via hCSN5 and therefore reflect an unappreciated mechanism promoting cancer cell proliferation.…”
Section: Discussionmentioning
confidence: 99%
“…As a result, the tetrazolium salt was reduced to purple formazan crystals by the metabolic activity of the mitochondrial succinate dehydrogenase enzyme. Then dimethyl sulfoxide solution (DMSO, Sigma Aldrich, St. Louis, MO, USA) was used to dissolve the formazan crystals [ 34 , 35 ]. It helped to measure the optical density (OD) intensity of the purple colour solution which directly attributed to the concentration of live cells present [ 36 ].…”
Section: Methodsmentioning
confidence: 99%
“…Pumilio-1 (PUM1) is an RNA-binding pumilio protein with a dramatically increased expression level in various tumor tissues. PUM1 stimulates tumor cell proliferation, motility, and colony formation in colon cancer, and is required to regulate tumor spherification [ 114 ]. TPL therapy decreased PUM1 expression in PC, activating autophagy to enhance TRAIL sensitivity in tumor cells.…”
Section: Natural Products Overcome Autophagy-mediated Tumor Drug Resi...mentioning
confidence: 99%