RNA Sequencing of Peripheral Blood Revealed that the Neurotropic TRK Receptor Signaling Pathway Shows Apparent Correlation in Recovery Following Spinal Cord Injury at Small Cohort

Wang, Chunqing; Lv, Hangzhou; Li, Qing; Gong, Ke; Yang, Lei; Wei, Zean; Pan, Yun; Wang, Mingyong

doi:10.1007/s12031-019-01273-4

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…Through the use of transcriptomics techniques, it was discovered that a number of RNAs showed abnormalities in SCI (22) and that these differentially expressed genes were primarily enriched in the neurotrophin TRK receptor signaling pathway, which indirectly suggested that the neurotrophin TRK receptor signaling pathway may be involved in the start of neurological regeneration. LncRNA and miRNA can be used to diagnose SCI, just like other RNAs.…”

Section: Transcriptomicsmentioning

confidence: 99%

Multi-omics in Spinal Cord Injury: Diagnosis, Prognosis, and Treatment

Xu¹,

Zhao²,

Zhou³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Section: Transcriptomicsmentioning

confidence: 99%

Multi-omics in Spinal Cord Injury: Diagnosis, Prognosis, and Treatment

Xu¹,

Zhao²,

Zhou³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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“…These biomarkers in general represent molecules released from damaged cells and the acute inflammatory response (acute biomarkers), molecules released during the cellular and immunological response while healing the injury (subacute biomarkers) (Kwon et al 2019 ). As peripheral blood is easily accessible and requires less invasive procedures, it was widely used in both animal studies and clinical trials for biomarker screening (Wang et al 2019 ). Such protein markers, including tumor necrosis factor-α (TNF-α) and interleukins (ILs), were identified in previous studies (Yousefifard et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Plasma Erythropoietin, IL-17A, and IFNγ as Potential Biomarkers of Motor Function Recovery in a Canine Model of Spinal Cord Injury

et al. 2020

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Traumatic spinal cord injury (SCI) is a devastating neurological disease for which an accurate, cost-effective prediction of motor function recovery is in pressing need. A plethora of neurochemical changes involved in the pathophysiological process of SCI may serve as a new source of biomarkers for patient outcomes. Five dogs were included in this study. We characterized the plasma cytokine profiles in acute phase (0, 1, and 3 days after SCI) and subacute phase (7, 14, and 21 days after SCI) with microarray analysis. The motor function recovery following SCI was monitored by Olby scores. The expression level of differentially expressed proteins (DEPs) was measured with enzyme-linked immunosorbent assay (ELISA). Then, correlations with the Olby scores and receiver operating characteristic curve (ROC) analysis were performed. We identified 12 DEPs including 10 pro-inflammatory and 2 anti-inflammatory cytokines during the 21-day study period. Among those, the expression levels of erythropoietin (EPO), IL-17A, and IFNγ significantly correlated with the Olby scores with R2 values of 0.870, 0.740, and 0.616, respectively. The results of the ROC analysis suggested that plasma EPO, IL-17A, and IFNγ exhibited a significant predictive power with an area under the curve (AUC) of 0.656, 0.848, and 0.800 for EPO, IL-17A, and IFNγ, respectively. Our results provide a longitudinal description of the changes in plasma cytokine expression in the acute and subacute stages of canine SCI. These data reveal novel panels of inflammation-related cytokines which have the potential to be evaluated as biomarkers for predicting motor function prognosis after SCI.

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The roles, molecular interactions, and therapeutic value of CDK16 in human cancers

Wang

Liu

et al. 2023

Biomedicine & Pharmacotherapy

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RNA Sequencing of Peripheral Blood Revealed that the Neurotropic TRK Receptor Signaling Pathway Shows Apparent Correlation in Recovery Following Spinal Cord Injury at Small Cohort

Cited by 4 publications

References 54 publications

Multi-omics in Spinal Cord Injury: Diagnosis, Prognosis, and Treatment

Multi-omics in Spinal Cord Injury: Diagnosis, Prognosis, and Treatment

Plasma Erythropoietin, IL-17A, and IFNγ as Potential Biomarkers of Motor Function Recovery in a Canine Model of Spinal Cord Injury

The roles, molecular interactions, and therapeutic value of CDK16 in human cancers

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