2002
DOI: 10.1016/s0969-8051(02)00307-4
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Robotic preparation of Sodium Acetate C 11 Injection for use in clinical PET

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Cited by 24 publications
(10 citation statements)
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“…Both LAPC-4 (androgen responsive) (Dr. Charles Sawyer at UCLA) and CWR22 (androgen responsive) (Bristol Myers Squibb) tumors were implanted and maintained by animalto-animal passage. 11 C-Labeled acetate was prepared by the reaction of 11 C-labeled carbon dioxide with a Grignard reagent as described previously (28). Radiochemical purity was always $99%.…”
Section: Generalmentioning
confidence: 99%
“…Both LAPC-4 (androgen responsive) (Dr. Charles Sawyer at UCLA) and CWR22 (androgen responsive) (Bristol Myers Squibb) tumors were implanted and maintained by animalto-animal passage. 11 C-Labeled acetate was prepared by the reaction of 11 C-labeled carbon dioxide with a Grignard reagent as described previously (28). Radiochemical purity was always $99%.…”
Section: Generalmentioning
confidence: 99%
“…Recently, solid phase extraction (SPE) has been used [191,192] instead of liquid-liquid extraction to isolate [190]. In a new automated system, a combination of a "loop method" for Grignard [ 11 C]carboxylation, where the radiochemical reaction takes place in an HPLC injector loop, and the SPE technique was employed in a very simple system which routinely produces 500 mCi of [ 11 C]acetate in about 12 minutes of total synthesis.…”
Section: Grignard Reagents [ 11 C]acetate Synthesismentioning
confidence: 99%
“…Because the MRI results were indeterminate for local recurrence of prostate carcinoma versus granulation tissue, a clinical PET study with 1-11 C acetate was requested. 1-11 C acetate was synthesized by a two-step carbonation/hydrolysis reaction, as previously described [29]. An injection of 39.7 mCi activity was administered.…”
Section: Case Reportmentioning
confidence: 99%