Robust, highly elastic and bioactive heparin-mimetic hydrogels

Abstract

We construct robust, highly elastic, and bioactive graphene oxide doped heparin-mimetic hydrogels for use in drug delivery and other potential biomedical applications.

Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications

“…Besides the robust and elastic mechanical properties, the in situ polymerization of vinyl monomers may also introduce multifunctional and biocompatible hydrogels. Cheng and Zhao et al have synthesized heparin-mimetic hydrogels via an one-pot in situ polymerization, Figure . In the heparin-mimetic hydrogel, GO is covalently doped into the networks of heparin-mimetic matrix due to the cross-linking between the initiated macromolecular radicals and sp 2 bonds of GO.…”

Three-Dimensional Graphene Oxide Skeleton Guided Poly(acrylic Acid) Composite Hydrogel Particles with Hierarchical Pore Structure for Hemoperfusion

“…Thus, the PAA hydrogels were formed by being attached to the GO skeleton by hydrogen bonds, and the obtained GO-PAA HPs showed a special hierarchical pore structure, which was totally different from the GO and PAA hybrids prepared by common blending methods. 37 Moreover, it was found that the pore walls of the GO-PAA HPs were much thinner than those of the PAA HPs, which might be attributed to the regulating effect and the super large specific surface area of the GO skeleton. For the GO-PAA25, with the same PAA content as PAA25, the thickness of the pore walls ranged from 347 to 599 nm, which was over 12 times thinner than that of PAA25.…”

“…This special pore structure might be explained as follows: GO sheets could be self-assembled into a porous network by the π–π stacking interaction and van der Waals forces; the high-strength PES template could provide a protective shell for the enwrapped GO aqueous solution, which could maintain the porous network during the process of mixing GO with AA. Thus, the PAA hydrogels were formed by being attached to the GO skeleton by hydrogen bonds, and the obtained GO-PAA HPs showed a special hierarchical pore structure, which was totally different from the GO and PAA hybrids prepared by common blending methods . Moreover, it was found that the pore walls of the GO-PAA HPs were much thinner than those of the PAA HPs, which might be attributed to the regulating effect and the super large specific surface area of the GO skeleton.…”

“…Graphene oxide (GO) is the nanomaterial that is often used as additive during the preparation of hydrogels . Thanks to the unique properties of GO, many performances of the nanocomposite hydrogels, including loading capacities and mechanical properties, can be improved and adjusted. − Various GO-based composite hydrogels with good adsorption capacity and hemocompatibility have been fabricated, indicating that the GO-based hydrogels have the potential application for hemoperfusion; however, there are still some challenges that need to be overcome. On the one hand, the higher swelling ratios made the mechanical properties of hydrogels unsteadied.…”

Graphene oxide and sulfonated polyanion co-doped hydrogel films for dual-layered membranes with superior hemocompatibility and antibacterial activity

“…[30][31][32][33] These functional polar groups enable easy dispersion of GO in many solvents to prepare GO doped sulfonated polyanion hydrogels. 34,35 It was also reported that GO showed good biocompatibility and could serve as a promising candidate for diverse biomedical applications. 36,37 Furthermore, GO also exhibited good compatibility with PES due to the hydrophobic interaction and π-π interaction.…”