Robust Revascularization, Despite Impaired VEGF Production, After Meniscus Allograft Transplantation in Rabbits

Xue, Cong; Zhang, Lei; Feng, Shi Ting; Zhang, Yadong; Zhang, Yichao; Luo, Dan; Kang, Xiaoqi; Wang, Xishun; Hou, Shuxun; Zhong, Hongshan

doi:10.1177/0363546513499139

Cited by 6 publications

(7 citation statements)

References 36 publications

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“…A study evaluating the post-transplantation properties of sheep meniscus using fresh sheep donor allografts demonstrated vascularity in all allografts at 4 months and, in fact, showed hypervascularity compared with the native knee 14 . One of the most robust studies to date on the revascularization of meniscus transplants occurred in rabbits and compared cryopreserved allografts with autografts 15 . In this study, vascularity was evaluated in numerous ways, including direct measurements of blood circulation through the various anatomic regions of the meniscus and histologic and genomic evaluations.…”

Section: Biologic Response To Transplantmentioning

confidence: 99%

A Transplant or a Patch? A Review of the Biologic Integration of Meniscus Allograft Transplantation

Lichtig,

Bedi,

Koh

et al. 2023

JBJS Reviews

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» After transplantation revascularization does occur although data are only available for animal models.» The time zero biomechanics, that is, the biomechanical properties at the time of transplant, of a meniscus allograft transplantation appear to appropriately mimic the original so long as the graft is sized correctly within 10% of the original and bone plug fixation is used.» Allograft type, that is, fresh vs. frozen, does not appear to affect the integration of the allograft.

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Section: Biologic Response To Transplantmentioning

confidence: 99%

A Transplant or a Patch? A Review of the Biologic Integration of Meniscus Allograft Transplantation

Lichtig,

Bedi,

Koh

et al. 2023

JBJS Reviews

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“…Xue et al [45] Neovascularization was defined as vessel growth mainly at the adhesion margin for less than one-third of the meniscus body ransverse diameter.…”

Section: Fenwick Et Al [2]mentioning

confidence: 99%

“…Blood vessels mainly origin from the medial and lateral geniculate arteries. However, in the mature skeleton, only the peripheral 10-25% of the meniscus receives blood supply from vessels attached to the synovial membrane [45]. This area is called the red-red zone [56].…”

Section: Neovascularization In Meniscal Lesions and Its Therapeutic Potentialmentioning

confidence: 99%

“…On the other hand, the neovascularization in the meniscus may be a regenerative response similar to the one observed in the tendinous tissue. The revascularization in the meniscus structure after transplantation is commonly observed and crucial to the healing process [45]. In the last decade, there has been a growing interest in using biological agents to enhance the healing of degenerative tissues in the knee joint [66][67][68].…”

Section: Neovascularization In Meniscal Lesions and Its Therapeutic Potentialmentioning

confidence: 99%

“…Xue et al revealed that, after meniscus transplantation, the meniscus body showed new vessel ingrowth mainly at the adhesion margin, while no significant vascular distribution was found at the free margin [45]. Moreover, blood circulation in vessels peaked after 8 weeks in the meniscus, mimicking the VEGF expression, which showed a progressive decrease with time, even though the vascular endothelial cells gradually increased over time.…”

Section: Neovascularization In Meniscal Lesions and Its Therapeutic Potentialmentioning

confidence: 99%

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Neovascularization in Meniscus and Tendon Pathology as a Potential Mechanism in Regenerative Therapies: Special Reference to Platelet-Rich Plasma Treatment

Szwedowski

Jaworski²,

Szwedowska³

et al. 2021

Applied Sciences

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Neovascularization is a complex, multistep process that includes the activation of endothelial cells, degradation of the basement membrane surrounding the blood vessel, formation of tip cells, the sprouting, migration and proliferation of endothelial cells into the interstitial space, and then the generation of space in the matrix to allow for the formation of a new, proper lumen of a newly formed blood vessel. Abundant neovascularization can be found in tendinous tissue obtained from asymptomatic athletes or the meniscus early after the injury. The concept of neovascularization in musculoskeletal system disorders seems to be mainly associated with pain and poor clinical outcomes. On the one hand, this phenomenon allows for tissue regeneration, but on the other, it is present during the degeneration process in connective tissue. Establishing the current concept on neovascularization is also needed. A narrative review of the current literature was conducted using databases including Embase, PubMed and Cochrane. This review aims to investigate the exact role of the neovascularization process in tendon and meniscus lesions and its role as a potential target in clinics, specifically in platelet-rich plasma (PRP) therapy. The stabilization of the neovessels required to achieve the healed tissue, together with the standardization of the PRP injections, can offer an alternative future therapeutic approach for the treatment of tendinopathy and meniscal injuries.

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Meniscal allograft transplantation. Part 1: systematic review of graft biology, graft shrinkage, graft extrusion, graft sizing, and graft fixation

Samitier

Alentorn-Geli

Taylor

et al. 2014

Knee Surg Sports Traumatol Arthrosc

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Robust Revascularization, Despite Impaired VEGF Production, After Meniscus Allograft Transplantation in Rabbits

Abstract: Our data provide test reference for clinical rehabilitation after meniscus autograft.

Cited by 6 publications

References 36 publications

A Transplant or a Patch? A Review of the Biologic Integration of Meniscus Allograft Transplantation

A Transplant or a Patch? A Review of the Biologic Integration of Meniscus Allograft Transplantation

Neovascularization in Meniscus and Tendon Pathology as a Potential Mechanism in Regenerative Therapies: Special Reference to Platelet-Rich Plasma Treatment

Meniscal allograft transplantation. Part 1: systematic review of graft biology, graft shrinkage, graft extrusion, graft sizing, and graft fixation

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