Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity

Chang, Chin Sung; Lu, Yan Jia; Chang, Hui Hua; Hsu, Shu-Hau; Kuo, Po-Chen; Shieh, Chi Chang; Yao, Wei Jen; Hsu, Mei Chi; Young, Kung Chia; Lin, Wen Yuan; Huang, Kuo Chin; Wu, Chih Hsing; Tsai, Yau Sheng

doi:10.1016/j.orcp.2016.05.003

Cited by 21 publications

(19 citation statements)

References 37 publications

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“…Furthermore, we found that MH subjects had a lower waist circumference compared with their MUH counterparts, even when both had the same body fat percentage. These results are supported by other studies where waist circumference is different between the healthy and unhealthy groups, but there were no differences in body fat percentage [ 24 , 25 , 26 , 27 ]. This suggests that not only the amount of body fat is an important factor in the development of metabolic complications, but also, the way fat is distributed.…”

Section: Discussionsupporting

confidence: 88%

Waist Circumference Is an Anthropometric Parameter That Identifies Women with Metabolically Unhealthy Phenotypes

et al. 2018

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Metabolically healthy (MH) and metabolically unhealthy (MUH) phenotypes can be present in any subject independently of their body mass index (BMI). However, factors related to the presence of these phenotypes are poorly understood. Therefore, the aim of this cross-sectional study is to describe the prevalence and characteristics associated with the MH and MUH phenotypes in Mexican subjects with different BMI categories. Anthropometric and biochemical parameters were evaluated after 12 h of fasting. HMW (High Molecular Weight) adiponectin and insulin levels were measured by ELISA (enzyme-linked immunosorbent assay). A total of 345 subjects were included, of which, 73.9% were women. The prevalence of the MH phenotype was 69.9%, 46.7%, and 19% in normal weight, overweight, and obesity, respectively. ROC (receiver operating characteristic) curve analysis showed that the waist circumference demonstrated a statistical significance (p < 0.01) in detecting the MUH phenotype in each BMI group only in women. Furthermore, subjects with lower HMW adiponectin levels showed a 2.1 increased risk of presenting the MUH phenotype. In conclusion, in this Mexican population, waist circumference was an anthropometric parameter that identified women with the MUH phenotype in all BMI categories and hypoadiponectinemia was a risk factor for the presence of this phenotype.

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Section: Discussionsupporting

confidence: 88%

Waist Circumference Is an Anthropometric Parameter That Identifies Women with Metabolically Unhealthy Phenotypes

et al. 2018

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“…Resistin is secreted mainly by the adipose tissue and is strongly associated with inflammatory markers (Qi et al, 2008). Adiponectin, secreted by adipocytes, has antiinflammatory properties (Chang et al, 2016) and plays important roles in glucolipid metabolism and atherosclerosis prevention (Chang et al, 2016). Adiponectin levels are reduced in obese and insulin-resistant animal models.…”

Section: Effects Of Dgp On Leptin Resistin and Adiponectinmentioning

confidence: 99%

Effects of replacing wheat flour with detoxified ginkgo nut powder on lipid metabolism of obese C57BL/6J male mice

Liu

Pei

Shi

et al. 2017

Food and Agricultural Immunology

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Effects of detoxified ginkgo nut powder (DGP) on lipid metabolism of obese mice were evaluated. Mice were divided into four groups: normal group (NC), hyperlipidaemic group (HC, high-fat feed), HC/ DGP group (high-fat diet + DGP), and HC/flour group (HC/WF, high-fat diet + flour). After 18 weeks, liver and body fat weights of HC/DGP were significantly lower than those of HC and HC/WF, but similar to those of NC. The serum and hepatic levels of serum triglyceride, total cholesterol, low-density lipoprotein cholesterol, leptin and resistin in HC/DGP were similar to those in NC but significantly lower than those in HC and HC/WF. In addition, the expression levels of PPARα (peroxisome proliferator-activated receptor alpha) in liver and of hormone-sensitive lipase, adipose triglyceride lipase, and monoacylglycerol lipase in epididymal fat were higher in HC/DGP than in other groups. The results revealed that DGP may reduce inflammation and promote normal lipid metabolism.

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“…Many studies have found that there exists a statistically significant inverse relationship between adiponectin and the amount of fat [40,41]. The level of serum insulin may be increased due to increased insulin resistance, an indication that the cells are non-responsive to insulin.…”

Section: Discussionmentioning

confidence: 99%

Effects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats

Jia

Liu

Zhou

et al. 2016

IJERPH

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The most widely used plasticizer, di-(2-ethylhexyl) phthalate (DEHP), is known to affect lipid metabolism and adipogenesis. We studied the effects of dietary DEHP exposure on metabolism in rats as well as the role of the JAK/STAT pathway in this process. Eighty rats were exposed to DEHP (0, 5, 50 and 500 mg/kg/d) through dietary intake for 4 weeks. We then collected blood samples, liver, and adipose tissues to detect modifications in the levels of serum lipids, leptin, adiponectin and insulin. JAK3, STAT5a and PPARγ expression were detected at both the gene and protein levels. The activation of JAK3 and STAT5a was also detected. The DEHP-exposed rats had increased body weight, serum lipid, insulin, and leptin levels. Moreover, the JAK3/STAT5a pathway was activated in the adipose tissue; however, this pathway was not activated in the liver. The mRNA of SREBP-1c in the liver was increased significantly among each of the groups, in contrast to the levels found in the mature SREBP-1c protein form. Furthermore, the expression of FABP4, Acox and FASn was decreased in the liver, but increased in adipose tissue. Thus, we conclude that exposure to DEHP reduces the hydrolysis of lipid and promotes triglyceride accumulation by oppositely regulating the activation state of JAK/STAT pathway in the liver and adipose tissue, resulting in the disorder of body lipid metabolism and obesity.

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Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity

Cited by 21 publications

References 37 publications

Waist Circumference Is an Anthropometric Parameter That Identifies Women with Metabolically Unhealthy Phenotypes

Waist Circumference Is an Anthropometric Parameter That Identifies Women with Metabolically Unhealthy Phenotypes

Effects of replacing wheat flour with detoxified ginkgo nut powder on lipid metabolism of obese C57BL/6J male mice

Effects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats

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