Role of antimicrobial photodynamic therapy in the treatment of aggressive periodontitis: A systematic review

Vohra, Fahim; Akram, Zohaib; Safii, Syarida Hasnur; Vaithilingam, Rathna Devi; Ghanem, Alexis; Sergis, Konstantinos; Javed, Fawad

doi:10.1016/j.pdpdt.2015.06.010

Cited by 99 publications

(45 citation statements)

References 38 publications

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“…The application of PIB has been investigated predominantly in vitro , elaborately reviewed in Wainwright et al ., less frequently in animal models or ex vivo , and only rarely in clinical studies. Among the few clinical studies, PIB application was studied in dentistry but very rarely in skin …”

mentioning

confidence: 99%

Photodynamic inactivation of bacteria to decolonize meticillin-resistant Staphylococcus aureus from human skin

et al. 2018

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mentioning

confidence: 99%

Photodynamic inactivation of bacteria to decolonize meticillin-resistant Staphylococcus aureus from human skin

et al. 2018

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“…Subsequently, antibiotics have been used to meet the challenges posed by bacterial infections in clinical and pharmacological research [22][23][24][25]. Early in the prevention or treatment of dental caries, systemic antibiotics showed potential efficacy [26,27]. We have highlighted some systemic antibiotics, including penicillin, tetracyclines, metronidazole, macrolides, and clindamycin, describing their application, mechanisms, side effects, and resistance.…”

Section: Systemic Antibioticsmentioning

confidence: 99%

Application of Antibiotics/Antimicrobial Agents on Dental Caries

Qiu

Zhou

et al. 2020

BioMed Research International

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Dental caries is the most common oral disease. The bacteriological aetiology of dental caries promotes the use of antibiotics or antimicrobial agents to prevent this type of oral infectious disease. Antibiotics have been developed for more than 80 years since Fleming discovered penicillin in 1928, and systemic antibiotics have been used to treat dental caries for a long time. However, new types of antimicrobial agents have been developed to fight against dental caries. The purpose of this review is to focus on the application of systemic antibiotics and other antimicrobial agents with respect to their clinical use to date, including the history of their development, and their side effects, uses, structure types, and molecular mechanisms to promote a better understanding of the importance of microbial interactions in dental plaque and combinational treatments.

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“…Then, the special fiber should be inserted 1 mm short of the pocket base and lased. 30 Photodynamic therapy has also been used to disinfect caries dentin before restoration, disinfecting oral tissues before or during surgical procedures, treating denture stomatitis, and treating oral candidiasis in immunocompromised patients. 31,32 With regard to bacteria involved in dental caries, Burns et al 33 showed that tolonium chloride (25 g/mL)…”

Section: Photodynamic Therapy In Dentistrymentioning

confidence: 99%

Photodynamic Therapy in Endodontics

Mohammadi¹,

Jafarzadeh²,

Shalavi³

et al. 2017

The Journal of Contemporary Dental Practice

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Commonly used irrigants do not always eradicate the entire microbial flora in infected root canals. Therefore, several other strategies, such as photodynamic therapy (PDT) have been developed. Photoactivated disinfection is based on the interaction of a photosensitive antibacterial agent and a light source. It uses a nontoxic dye named photosensitizer (PS) and lowintensity visible light. In oxygen presentation, these combine to produce some cytotoxic species. The PS molecules attach to bacteria membrane. Irradiation with a specific wavelength of the light may lead to the production of singlet oxygen, resulting in rupture of the microbial cell wall. There are several applications for PDT in dentistry. A successful periodontal treatment is based on elimination of bacteria from the infected area. Phenothiazinium PSs have been shown to be highly effective and safe for this purpose. However, scaling/root planing should be performed before the PDT. While performing the PDT, PS should be first injected in the periodontal pocket and allowed to pigment. Then, the special fiber should be inserted 1 mm short of the pocket base and lased. Photodynamic therapy has also been used to disinfect caries dentin before restoration, disinfecting oral tissues before or during surgical procedures, treating denture stomatitis, and treating oral candidiasis in immunocompromised patients. Photodynamic therapy can be used in combination with mechanical instrumentation and chemical antimicrobial agents, such as sodium hypochlorite, too. The purpose of this study was to review historical perspective, mechanism of action, and applications of PDT in dentistry and especially in endodontics was reviewed. Furthermore, the effects of PDT on dentin bonding and endotoxin are discussed.Clinical significance: Photodynamic therapy has been advocated to increase the disinfection level of the root canal system.

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Role of antimicrobial photodynamic therapy in the treatment of aggressive periodontitis: A systematic review

Cited by 99 publications

References 38 publications

Photodynamic inactivation of bacteria to decolonize meticillin-resistant Staphylococcus aureus from human skin

Photodynamic inactivation of bacteria to decolonize meticillin-resistant Staphylococcus aureus from human skin

Application of Antibiotics/Antimicrobial Agents on Dental Caries

Photodynamic Therapy in Endodontics

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