Role of CD4- and CD8-Positive T Cells in Breast Cancer Progression and Outcome: A Pilot Study of 47 Cases in Central India Region

Deshmukh, Abhay Vilas; Gupta, Anupama; Rathod, Raju Ratansingh; Gangane, Nitin

doi:10.1007/s40944-020-00454-z

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…We performed a deep-immunophenotyping of CD45 pos cells through the evaluation of immune cells, with particular reference to the lymphocyte subpopulations and monocytes. According to recent observations of our research group in peripheral blood [ 34 ], we found that in the case of BC onset the tumor microenvironment featured by a higher percentage of CD4 pos T cells in comparison to fibroadenoma, as previously reported [ 35 , 36 , 37 ]. However, the percentage of activated CD4+ T cells was lower in case of BC malignancies.…”

Section: Discussionsupporting

confidence: 80%

Identification of Immune Cell Components in Breast Tissues by a Multiparametric Flow Cytometry Approach

Coppola¹,

Smaldone²,

D’aiuto³

et al. 2022

Cancers

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Immune cell components are able to infiltrate tumor tissues, and different reports described the presence of infiltrating immune cells (TILs) in several types of solid tumors, including breast cancer. The primary immune cell component cells are reported as a lymphocyte population mainly comprising the cytotoxic (CD8+) T cells, with varying proportions of helper (CD4+) T cells and CD19 + B cells, and rarely NK cells. In clinical practice, an expert pathologist commonly detects TILs areas in hematoxylin and eosin (H&E)-stained histological slides via light microscopy. Moreover, other more in-depth approaches could be used to better define the immunological component associated with tumor tissues. Using a multiparametric flow cytometry approach, we have studied the immune cells obtained from breast tumor tissues compared to benign breast pathologies. A detailed evaluation of immune cell components was performed on 15 and 14 biopsies obtained from breast cancer and fibroadenoma subjects, respectively. The percentage of tumor-infiltrating T lymphocytes was significantly higher in breast cancer patients compared to patients with fibroadenoma. Infiltrating helper T lymphocytes were increased in the case of malignant breast lesions, while cytotoxic T lymphocytes disclosed an opposite trend. In addition, our data suggest that the synergistic effect of the presence/activation of NK cells and NKT cells, in line with the data in the literature, determines the dampening of the immune response. Moreover, the lymphocyte-to-monocyte ratio was calculated and was completely altered in patients with breast cancer. Our approach could be a potent prognostic factor to be used in diagnostic/therapeutic purposes for the improvement of breast cancer patients’ management.

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Section: Discussionsupporting

confidence: 80%

Identification of Immune Cell Components in Breast Tissues by a Multiparametric Flow Cytometry Approach

Coppola¹,

Smaldone²,

D’aiuto³

et al. 2022

Cancers

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“…There are studies which show increase intertumoral infiltration of CD4+ T cells in breast cancer but it did not bode well with prognosis of the disease [40]. There is also the involvement of soluble factors like IL-10, TGF-β, IL-6 and PGE2 in this conversion.…”

Section: Immunomodulatory Effects Of Mscs On T Cellsmentioning

confidence: 95%

The Multifunction Role of Tumour-Associated Mesenchymal Stem Cells and their Interaction with Immune Cells

Gautam¹

2022

J Oncology

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Mesenchymal Stem Cells (MSCs) are multipotent stromal cells that are present in the various parts of the body. MSCs tends to migrate towards inflamed regions and they are also seen to migrate to a tumour. The immunomodulatory properties of the MSCs were being studied for the past decade and it has been observed that these immunomodulatory properties of MSCs have been exploited by the cancer stoma.

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The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer

Chauhan,

Agarwal,

Masih

et al. 2023

Immunological Investigations

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Role of CD4- and CD8-Positive T Cells in Breast Cancer Progression and Outcome: A Pilot Study of 47 Cases in Central India Region

Cited by 3 publications

References 23 publications

Identification of Immune Cell Components in Breast Tissues by a Multiparametric Flow Cytometry Approach

Identification of Immune Cell Components in Breast Tissues by a Multiparametric Flow Cytometry Approach

The Multifunction Role of Tumour-Associated Mesenchymal Stem Cells and their Interaction with Immune Cells

The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer

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