Role of Confocal Endomicroscopy in the Diagnosis of Celiac Disease

Venkatesh, Krishnappa; Abou‐Taleb, Ashraf; Cohen, Marta C.; Evans, Clair; Thomas, Steven; Oliver, Philip; Taylor, C.; Thomson, Mike

doi:10.1097/mpg.0b013e3181d1b02c

Cited by 32 publications

(13 citation statements)

References 24 publications

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“…Such diagnostic protocols have even been applied to pediatric endoscopy in 19 children from 2-12.66 years and have shown good sensitivity and specificity of 100% and 80%, resp. [25] 4. Lower gastrointestinal tract…”

Section: Endomicroscopy Of the Small Intestinementioning

confidence: 99%

Confocal laser endomicroscopy in gastrointestinal diseases

Goetz

Watson

Kießlich

2011

Journal of Biophotonics

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Confocal laser endomicroscopy (CLE) is a novel endoscopic technique permitting in vivo microscopy (optical biopsies) of the gastrointestinal mucosa. CLE has been studied in a multitude of diseases of the upper and lower gastrointestinal tract, including Barrett's esophagus, gastric inflammation and cancer, celiac disease, colorectal adenoma and carcinoma, and inflammatory bowel diseases. CLE has recently evolved and been studied for bile duct and liver imaging. CLE has shown overall high accuracy and enabled smart, targeted biopsies rather than untargeted sampling. Furthermore, the availability of real time microscopic information during endoscopy has immediate impact on therapeutic decisions and guides endoscopic interventions. CLE is also a unique tool for observation of (patho-)physiologic events in their natural environment (functional imaging) and has been linked to molecular imaging of gastrointestinal neoplasia in vivo, thereby broadening our understanding of mucosal pathology in clinical and basic science.

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Section: Endomicroscopy Of the Small Intestinementioning

confidence: 99%

Confocal laser endomicroscopy in gastrointestinal diseases

Goetz

Watson

Kießlich

2011

Journal of Biophotonics

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“…oceniali przydatność endomikroskopii konfokalnej w rozpoznawaniu choroby trzewnej. Według autorów przy powiększeniu obrazu endoskopowego około 1000 razy można ocenić błonę śluzową dwunastnicy z dokład -nością porównywalną z badaniem histopatologicznym i potwierdzić rozpoznanie choroby trzewnej [11]. [1].…”

Section: Wprowadzenieunclassified

New guidelines for diagnosis and treatment of coeliac disease in children and adolescents

Iwańczak¹,

Iwańczak²

2012

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StreszczenieW ostatnich latach ukazały się nowe wytyczne dotyczące rozpoznawania i leczenia choroby trzewnej u dzieci i młodzieży opracowane przez ekspertów ESPGHAN, NASPGHAN i AGA Institute. W pracach tych przedstawiono definicję i klasyfikację choroby trzewnej, wskazania do diagnozowania, aspekty kliniczne, znaczenie badania HLA, badań serologicznych i biopsji dwunastnicy. Przedstawiono także algorytmy postę-powania diagnostycznego z pacjentami z objawami i bez objawów chorobowych oraz algorytm monitorowania leczenia. AbstractIn the last years new guidelines for the diagnosis and treatment of coeliac disease in children and adolescents, developed by ESPGHAN, NASPGHAN and AGA Institute, were published. These publications presented the definition and clas sification of coeliac disease, indications for diagnostic investigation, clinical aspects, importance of HLA and serological investigation as well as duodenal biopsy. The diagnostic algorithm in patients with and without symptoms and the algorithm for treatment monitoring were described.

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“…CLE has even been studied in children for the diagnosis of celiac disease. In 19 patients, sensitivity and specificity were 100% and 80%, respectively [45].…”

Section: Endomicroscopy Of the Small Intestinementioning

confidence: 99%

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Goetz

2012

ISRN Pathology

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Confocal laser endomicroscopy (CLE) is a novel tool in the endoscopist's armamentarium. It allows on-site histological information. The ability of gastroenterologists to interpret such microscopic information has been demonstrated in multiple studies from the upper and lower gastrointestinal tract. Recently, the field of application has expanded to provide hepatobiliary and intra-abdominal CLE imaging. CLE allows "smart," targeted biopsies and is able to guide endoscopic interventions. But CLE is also translational in its approach and permits functional imaging that significantly impacts on our understanding of gastrointestinal diseases. Molecular imaging with CLE allows detection and characterization of lesions and may even be used for prediction of response to targeted therapy. This paper provides a comprehensive review over current applications of CLE in clinical applications and translational science.

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Role of Confocal Endomicroscopy in the Diagnosis of Celiac Disease

Abstract: Confocal endomicroscopy offers the prospect of diagnosis of CD during ongoing endoscopy. It also enables targeting biopsies to abnormal mucosa and thereby increasing the diagnostic yield, especially when villous atrophy is patchy in the duodenum.

Cited by 32 publications

References 24 publications

Confocal laser endomicroscopy in gastrointestinal diseases

Confocal laser endomicroscopy in gastrointestinal diseases

New guidelines for diagnosis and treatment of coeliac disease in children and adolescents

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

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