Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females

Abstract

C1q complement/tumor necrosis factor (TNF)—related protein (CTRP) family comprises of 15 proteins that posses important implications in energy homeostasis, infection and inflammation. However, their roles in diabetes mellitus (DM) and its vascular complications have not been completely assessed. This works aims to study the association of two CTRPs; 3 and 9, with pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery disease (CAD).Methods: Biochemical markers and serum levels of CTRPs and MCP-1 were measured in 86 postmenopausal females. Subjects were divided over four groups; 13 apparent healthy subjects as control (group I), 29 patients with CAD (group II), 29 patients with T2D ≥5 years (group III) and 15 patients with CAD secondary to T2D (group IV). Serum CTRP3, CTRP9, MCP-1 and insulin were measured by ELISA.Results: Serum CTRP3 levels were found to be significantly higher in group III and IV, whereas, it was significantly lower in group II on comparing to group I. While, CTRP9 levels were significantly decreased in group II, III and IV on comparing to group I. MCP-1 levels were found to be significantly increased in groups II, III and IV on comparison with group I. Both CTRPs were significantly negatively correlated with each other. While MCP-1 was significantly correlated negatively to CTRP9.Conclusion: This study associates the possible role of CTRP3, CTRP9 and MCP-1/CCL2 in the diagnosis/prognosis of CAD complication in T2D postmenopausal females.

Cytokines and Abnormal Glucose and Lipid Metabolism

“…In contrast, MCP-1 knockout mice and inhibition of MCP-1 activity exhibited improvements in insulin resistance and hepatic steatosis (96, 97). Consistent with the findings in mice, humans show increased plasma levels of MCP-1 in T2D (98).…”

RETRACTED: Protective Effect of Xinmailong Injection on Rats With Myocardial Infarction

“…The inflammatory response is one of major causes of myocardial damage. The levels of inflammatory factors and chemokines in the myocardial tissue are elevated rapidly after myocardial injury in AMI, further exacerbate the inflammatory response and aggravate myocardial infarction, ventricular remodeling, and other forms of cardiac dysfunction ( Ahmed et al, 2018 ). In this study, the levels of inflammatory factors CRP, and myocardial markers such as CK and CK-MB, were significantly lower in the Xinmailong group compared with the control group, suggesting that Xinmailong injection has certain anti-inflammatory effects and protect against myocardial damage.…”

C1q/TNF‐related protein‐9 is elevated in hypertension and associated with the occurrence of hypertension‐related atherogenesis

“…In an earlier study, Wang et al reported that both CTRP9 levels in serum and CTRP9 mRNA expression in epicardial adipose tissue were decreased in coronary artery disease (CAD) patients compared with non‐CAD patients (Wang et al, 2015; Yu et al, 2018). In a study of postmenopausal women, Ahmed et al (2018) found that CTRP9 levels were decreased in both T2DM and CAD and further decreased in T2DM patients with CAD. Moreover, in patients with chronic heart failure and reduced ejection fraction, plasma CTRP9 levels were observed to be decreased compared with control patients, and CTRP levels were gradually reduced in the New York Heart Association (NYHA) functional Class II, NYHA III, and NYHA IV groups and positively correlated with left ventricular ejection fraction (LVEF) but negatively correlated with N‐terminal pro‐brain natriuretic peptide (NT‐proBNP; Gao et al, 2019).…”