Role of Depression in Predicting Time to Conversion to Mild Cognitive Impairment

Dean, Katherine; Oulhaj, Abderrahim; Zamboni, Giovanna; de-Jager, Celeste; Wilcock, Gordon

doi:10.1016/j.jagp.2012.12.025

Cited by 18 publications

(17 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our finding that depression or depressive symptoms at baseline were associated with incident MCI after adjusting for potential confounders is in accordance with prior community-based studies on this topic with longitudinal design which have also shown that baseline depressive disorder [10,52] or depressive symptomatology [11,44,53,54,55,56,57,58,59] are significant predictors of incident MCI. For instance, a study by Steenland et al [52] found that depression, based on clinical judgment, significantly predicted incident MCI in 5,607 individuals with a mean age of 73 years.…”

Section: Discussionsupporting

confidence: 92%

The Impact of Depression on the Development of Mild Cognitive Impairment over 3 Years of Follow-Up: A Population-Based Study

Lara¹,

Koyanagi²,

Domènech‐Abella³

et al. 2017

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: In the absence of effective treatments for dementia, major efforts are being directed towards identifying the risk factors of the prodromal phase of the disease. We report the incidence rates of mild cognitive impairment (MCI) in a Spanish population sample and assess the effect of depression at baseline on incident MCI (or MCI subtypes) at a 3-year follow-up. Methods: A total of 1,642 participants (age ≥50 years) were examined as part of a Spanish nationally representative longitudinal study. MCI was defined as the presence of cognitive concerns, objective evidence of impairment in one or more cognitive domains, preservation of independence in functional abilities, and no dementia. Depression was assessed through an adaptation of the Composite International Diagnostic Interview (CIDI 3.0). Binary and multinomial logistic regression analyses were carried out to assess the associations. Results: The overall MCI incidence rate was 33.19 (95% CI = 26.02, 43.04) per 1,000 person-years. Depression at baseline predicted the onset of MCI at follow-up after controlling for sociodemographics, cognitive functioning, and other physical health conditions (OR = 2.79; 95% CI = 1.70, 4.59). The effect of baseline depression on incident MCI subtypes was as follows: amnestic MCI, OR = 3.81 (95% CI = 1.96, 7.43); nonamnestic MCI, OR = 2.03 (95% CI = 0.98, 4.21). Conclusion: Depression significantly increases the risk for MCI. Targeting depression among those at risk for dementia may help delay or even prevent the onset of dementia.

show abstract

Section: Discussionsupporting

confidence: 92%

The Impact of Depression on the Development of Mild Cognitive Impairment over 3 Years of Follow-Up: A Population-Based Study

Lara¹,

Koyanagi²,

Domènech‐Abella³

et al. 2017

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…We concur with the observation that "Functional recovery after a major depressive episode (MDE) requires both clinical remission and preservation of cognitive skills" [30]. Study of the prevalence and impact of cognitive impairment in relatively young patients with MDD is limited but a detrimental interplay between MDD and cognition is amply documented in older adults: depression may accelerate the conversion to overt cognitive impairment [9], while impaired executive function has been linked to worse responses to treatments for depression [31] and greater costs of depression treatment [13]. Particularly for younger adults with parental and employment responsibilities, executive functioning is probably the most important aspect of cognition.…”

Section: Discussionsupporting

confidence: 80%

“…Impairment of cognitive function is a frequent comorbidity associated with major depressive disorders (MDD) and one of the most widely encountered residual sequelae of MDD, persisting even in remitted MDD [1][2][3]. The precise nature of the physiological, anatomical and functional inter-relations between depression and cognitive impairment is complex and incompletely understood at present although it is being explored in various lines of research [4][5][6][7][8][9][10][11]. Much of this research is focused on older adults but the connection between MDD and cognitive limitation is also apparent in younger adults, in whom it may have a direct negative impact on work productivity, especially in the form of 'presentee-ism' [12], and perhaps wider consequences with regard to their capacity to discharge the responsibilities of adult life as well as affecting the costs of care [13].…”

Section: Introductionmentioning

confidence: 99%

Effects of Fluvoxamine on Cognitive Function in Outpatients with Depression in Remission: Results of an Open-Label Pilot Study

Бобров¹,

Краснослободцева²,

Mutnykh³

2017

J Psychiatry

View full text Add to dashboard Cite

A prospective, non-comparative, single-centre, single-group study was conducted in 50 adult patients with currently remitted recurrent depressive disorder according to the criteria of the International Classification of Diseases, 10th revision in order to assess changes in cognitive function during preventive therapy with fluvoxamine. Responses to therapy were evaluated using the Stroop Color and Word Test as the primary efficacy outcome. The revised Addenbrooke's Cognitive Examination, Frontal Assessment Battery, Hamilton Rating Scale for Depression and Social Adaptation Self-evaluation Scale were used as secondary indices. Fluvoxamine was administered at doses of 50-150 mg/day for 24 weeks. Fluvoxamine therapy was associated with a range of 'pro-cognitive' responses that resulted in improvement in executive functions, including improved voluntary regulation of inhibitory control and restoration of verbal fluency. No dose relation was apparent for these effects. The incidence of treatmentrelated adverse events was low and no serious or severe events were recorded. These findings indicate that further studies of fluvoxamine are warranted and feasible to characterize possible beneficial effects on cognitive processes in patients with depression.

show abstract

“…We included an abbreviated depression scale, which should help to discriminate dementia from depression. However, depression may be either a risk factor for, or a consequence of, memory loss [ 24 ]. We found that the screen positives had higher self-reports of depressive symptoms than the screen negatives.…”

Section: Discussionmentioning

confidence: 99%

Dementia Prevalence in a Rural Region of South Africa: A Cross-Sectional Community Study

Jager

Msemburi

Pepper

et al. 2017

JAD

View full text Add to dashboard Cite

Background:Dementia is a growing concern for low- and middle-income countries where longevity is increasing and service provision is poor. Global prevalence estimates vary from 2% to 8.5% for those aged 60 years and older. There have been few dementia studies in sub-Saharan Africa, and prevalence data are lacking for South Africa.Objective:To conduct a large dementia prevalence study in a low income rural population in South Africa.Methods:1,394 Xhosa-speaking community dwellers, aged ≥60 y (mean age±sd 71.3±8.3 y), in three clinic catchment areas, were screened at home. Trained community health workers administered the brief Community Screening Instrument for Dementia (CSID) to participants and informants to assess cognitive and functional capacity. Depressive symptoms were assessed with three questions from the EURO-D.Results:The prevalence estimate using published CSID sensitivity/specificity values was 0.8 (95% CI: 0.06–0.09). Using CSID cut-off scores the estimated prevalence was 0.12 (95% CI: 0.10–0.13), with 161 screen-positives. Both methods gave a rate of 0.11 (95% CI: 0.09–0.13) for those over 65 years (n = 1051). 68.6% of participants were female and 69.8% had less than 7 years of education. Dementia risk was associated with older age and symptoms of depression, but not with sex. The association with education was not significant when controlled for by age.Conclusions:Dementia prevalence estimates were higher than expected for this low-income rural community. There is a need for increased dementia awareness and feasible support interventions. We also need further studies of regional prevalences, dementia subtypes, and modifiable risk factors in South Africa.

show abstract

Role of Depression in Predicting Time to Conversion to Mild Cognitive Impairment

Cited by 18 publications

References 36 publications

The Impact of Depression on the Development of Mild Cognitive Impairment over 3 Years of Follow-Up: A Population-Based Study

The Impact of Depression on the Development of Mild Cognitive Impairment over 3 Years of Follow-Up: A Population-Based Study

Effects of Fluvoxamine on Cognitive Function in Outpatients with Depression in Remission: Results of an Open-Label Pilot Study

Dementia Prevalence in a Rural Region of South Africa: A Cross-Sectional Community Study

Contact Info

Product

Resources

About