Role of duodenal mucosal nerve endings in the acid‐induced duodenogastric sensorimotor reflex: Effect of benzocaine in healthy humans

Vanuytsel, Tim; Karamanolis, George; Vos, Rita De; Oudenhove, Lukas Van; Farré, Ricard; Tack, Jan

doi:10.1111/nmo.12126

Cited by 6 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings suggested that duodenal acid infusion could induce dyspeptic symptoms in health, further confirming that increased duodenal acid exposure may be a pathogenic factor in FD . Increased duodenal acid exposure further provoked gastroduodenal reflex that induced gastric relaxation and sensitized the proximal stomach to distension, a finding confirmed in later studies …”

Section: Pathogenesissupporting

confidence: 54%

Functional dyspepsia and duodenal eosinophilia: A new model

Fan

Talley

2017

J of Digest Diseases

View full text Add to dashboard Cite

Functional dyspepsia (FD) is a highly prevalent disorder that affects more than 10% of the population. In the past decade, the theoretical underpinning of the concept of FD has begun to change, in light of new data on the underlying pathophysiological mechanisms of this disorder, with a focus on the duodenum. The Rome IV criteria, published in 2016, note that gastroesophageal reflux disease and irritable bowel syndrome overlap with FD more than expected by chance, suggesting that they may be part of the same disease spectrum. Infection by Helicobacter pylori (H. pylori) may explain a minority of cases of FD and in the Rome IV criteria H. pylori-associated dyspepsia (defined as symptom relief after eradication therapy) is considered a separate entity. Duodenal inflammation characterized by increased eosinophils and in some cases mast cells, may impair the intestinal barrier. Post-infectious gastroenteritis is now an established risk factor for FD. Other risk factors may include atopy, owning herbivore pets and exposure to antibiotics, together with gastroduodenal microbiome disturbances. Small bowel homing T cells and increased cytokines in the circulation occur in FD, correlating with slow gastric emptying, and a possible association with autoimmune rheumatological disease supports background immune system activation. A genetic predisposition is possible. FD has been linked to psychological disorders, but in some cases psychological distress may be driven by gut mechanisms. Therapeutic options are limited and, aside from responders to H. pylori eradication, provide only modest and temporary relief. Advances in understanding FD may alter clinical practice, and the treatment of duodenal inflammation or microbiome alterations may lead to a cure for a subset of these patients in the future.

show abstract

Section: Pathogenesissupporting

confidence: 54%

Functional dyspepsia and duodenal eosinophilia: A new model

Fan

Talley

2017

J of Digest Diseases

View full text Add to dashboard Cite

show abstract

“…Another mechanism is a modified duodenogastric reflux due to duodenal hypersensitivity to acid. This duodenogastric reflux determines gastric relaxation, inhibition of antral motility, and sensitization of the proximal stomach to distension 23 . All these influence the perception, interpretation, and the responses to environmental factors which at their turn can be also involved 10,24,25 .…”

Section: Pathogenesis Of Fdmentioning

confidence: 99%

Treatment with probiotics in functional dyspepsia

Surdea-Blaga¹,

Chira²,

Dumitraşcu³

2021

NGL

View full text Add to dashboard Cite

“…41,42 A su vez, se demostró que la administración exógena de ácido en el duodeno disminuye el umbral de sensibilidad frente a la distensión gástrica con balón e inhibe la acomodación gástrica posprandial. 43,44 La infusión intraduodenal de lípidos sensibiliza al estómago a la distensión en pacientes con DF, 45 lo que podría explicar el motivo por el cual las comidas grasas pueden empeorar los síntomas relacionados al llenado gástrico.…”

Section: Disfunción Motora Y Sensorial Gastroduodenalunclassified

Dispepsia funcional y gastroparesia: ¿dos entidades superpuestas? De la fisiopatología a la terapéutica

Manresa¹,

Carboné²,

Díez³

2021

Acta gastroenterol. latinoam.

View full text Add to dashboard Cite

Functional dyspepsia and gastroparesis represent the most common sensory-motor disorders of the upper gastrointestinal tract. Scientific advances in the last decade have shown that there is significant overlap between them. This review aims to address current knowledge about their pathophysiology, diagnosis and treatment. Functional dyspepsia is a medical condition that is characterized by one or more of the following symptoms: early satiety, postprandial fullness, and epigastric pain or burning. The pathophysiological mechanisms involved are: the gastroduodenal motility and sensory abnormalities, the immune dysfunction, the duodenal inflammation, the gastrointestinal infections, the alterations in the gastrointestinal microbiota and the dysfunction of the gut-brain axis. The Rome IV criteria make possible to establish a presumptive diagnosis of functional dyspepsia in most patients, although it continues to be a diagnosis of exclusion that requires the performance of an upper digestive video endoscopy to confirm it. The recommended therapeutic options are: the eradication of Helicobacter pylori, the proton pump inhibitors, the tricyclic antidepressants and prokinetics. Gastroparesis is a chronic disorder characterized by delayed gastric emptying in the absence of a mechanical obstruction. The pathophysiology is caused by neuromuscular abnormalities of gastric motor function. Gastric emptying scan is the current gold standard for diagnosis. The mainstays of treatment are restoration of hydration and nutrition, and pharmacological treatment with prokinetics and antiemetics.

show abstract

Role of duodenal mucosal nerve endings in the acid‐induced duodenogastric sensorimotor reflex: Effect of benzocaine in healthy humans

Cited by 6 publications

References 33 publications

Functional dyspepsia and duodenal eosinophilia: A new model

Functional dyspepsia and duodenal eosinophilia: A new model

Treatment with probiotics in functional dyspepsia

Dispepsia funcional y gastroparesia: ¿dos entidades superpuestas? De la fisiopatología a la terapéutica

Contact Info

Product

Resources

About