Covid-19, a once-in-a-century pandemic, has caused a great deal of anxiety worldwide. In addition to the apparent virus-induced morbidity and mortality, pandemicinduced stress has contributed to the lack of human wellbeing during Covid-19. Most efforts have gone into understanding the physical effects and less on the pandemic's mental effects. The new normal of social distancing and work-from-home (WFH), requiring disconcerting home confinement levels, has been a prime cause of stress.The pandemic-induced stress encompasses infection-related suffering, economic and professional loss, social isolation caused by lockdowns, information-induced anxiety, need to integrate work and life-from earlier balancing them, and stress-induced by sudden changes in the routine. The study's primary objective is to develop and validate a scale to measure lockdown and WFH-induced stress among professionals in employment. The result indicates three significant stressors: job stress, social stress, and routine stress affecting professionals due to lockdown and WFH. The study results would help employers, and healthcare professionals measure the lockdown and WFH-induced stress among working professionals, which is a prerequisite for managing the same through appropriate interventions.