Role of Endogenous Nitric Oxide in Airflow Obstruction in Smokers

Kanazawa, Hiroshi; Shoji, Seiichi; Hirata, Kazuto; Kurihara, Naotsugu; Yoshikawa, Junichi

doi:10.1378/chest.110.4.927

Cited by 18 publications

(13 citation statements)

References 15 publications

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“…This may not only have consequences for monitoring patients with COPD, but also for the natural history and prognosis of the disease. The positive relationship between exhaled NO levels and FEV 1 12 15 36 is in keeping with the hypothesis that endogenous NO represents an important protective mechanism. This could be particularly relevant in patients with COPD who may require local NO release for antimicrobial host defence26 27 or preservation of ventilation/perfusion matching within the lung 37.…”

Section: Discussionsupporting

confidence: 86%

Exhaled nitric oxide in COPD: glancing through a smoke screen

Sterk

Gouw

Ricciardolo

et al. 1999

Thorax

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Section: Discussionsupporting

confidence: 86%

Exhaled nitric oxide in COPD: glancing through a smoke screen

Sterk

Gouw

Ricciardolo

et al. 1999

Thorax

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“…Moreover, though our findings confirm those of Kanazawa et al 18 who studied levels of exhaled NO in smokers with mild obstruction, they contradict Maziak and co-workers13 who found an inverse correlation between FEV 1 and exhaled NO levels in patients with COPD. This discrepancy could be explained by the fact that Maziak et al 13 correlated levels of exhaled NO and FEV 1 in both stable and unstable COPD patients.…”

Section: Discussionsupporting

confidence: 58%

Increased exhaled nitric oxide in patients with stable chronic obstructive pulmonary disease

Corradi

Majori

Cacciani

et al. 1999

Thorax

133

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Background-Nitric oxide (NO) plays an important role as an inflammatory mediator in the airways. Since chronic obstructive pulmonary disease (COPD) is characterised by airway inflammation, a study was undertaken to determine NO levels in the exhaled air of patients with COPD. Methods-Two groups of patients with clinically stable COPD were studied, 10 current smokers and 10 ex-smokers. Two control groups of healthy subjects consisting of 10 current smokers and 20 nonsmokers were also studied. Exhaled NO levels were measured by the collection bag technique and NO chemiluminescence analyser. Results-Mean (SE) levels of exhaled NO in ex-smokers and current smokers with COPD (25.7 (3.0) ppb and 10.2 (1.4) ppb, respectively) were significantly higher than in non-smoker and current smoker control subjects (9.4 (0.8) ppb and 4.6 (0.4) ppb, respectively). In current smokers with COPD exhaled levels of NO were significantly lower than in ex-smokers. In this latter group of patients there was a significant negative correlation between smoking history (pack years) and levels of exhaled NO (r = -0.8, p = 0.002). A positive correlation was seen between forced expiratory volume in one second (FEV 1 ) and levels of exhaled NO (r = 0.65, p = 0.001) in patients with COPD. Conclusions-These data show that exhaled NO is increased in patients with stable COPD, both current and exsmokers, compared with healthy control subjects.

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“…73 centrations will affect V NO measurements by altering the concentration gradient between tissue and airway/ Smoking alveolus. Experimental results have been discordant with some authors reporting a correlation between Chronic cigarette smokers have lower levels of exhaled FENO and ambient NO values greater than about NO than nonsmokers [74][75][76][77] and there is a correlation 20 ppb. 46,[54][55][56] In fact, when subjects are exposed to between the reduction in exhaled NO and the number variable levels of outdoor pollution, read as increasing of cigarettes smoked.…”

Section: Nasal Nomentioning

confidence: 40%