Role of endogenous opioid peptides in the pathogenesis of motion sickness

Yasnetsov, V. V.; Vakulina, O. P.; Sabaev, V. V.; Mokrousova, A. V.; Карсанова, С. К.; Il'ina, S. L.; Медведев, О. С.; Shashkov, V. A.; Tigranyan, R.A.

doi:10.1007/bf00837379

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…However, to confirm the validity of this finding it would be necessary to design a clinical study to provoke motion sickness in volunteers who have had opioids administered. The previous observation in a study of similar characteristics that naloxone was more efficacious than the reference drug scopolamine, could be said to point the same way [68].…”

Section: Discussionmentioning

confidence: 78%

Prophylactic ondansetron for post-operative emesis: meta-analysis of its effectiveness in patients with and without a previous history of motion sickness

Figueredo

1999

Eur J Anaesthesiol

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The post-operative anti-emetic efficacy of 4 and 8 mg of ondansetron in adult patients with and without a previous history of motion sickness (PHMS) was assessed by meta-analysis. MEDLINE and EMBASE databases were searched for randomized placebo-controlled trials evaluating the anti-emetic effectiveness of ondansetron in a 24-h period. In the 49 studies found, a further selection was with respect to those studies that noted the patient's previous history of motion sickness. Twelve trials involving 2122 patients; 446 previous history of motion sickness(+) patients and 1676 previous history of motion sickness(-) patients met the selection criteria. The dose of 4 mg ondansetron was 71.5% more effective in previous history of motion sickness(+) than in previous history of motion sickness(-) patients. For the 8 mg dose, the odds ratios (95% CI) were: previous history of motion sickness(+) = 3.11 (1.40-6.93) and previous history of motion sickness(-) = 2.08 (1.35-3.21). The calculated number needed to treat was also more favourable in previous history of motion sickness(+) patients for both doses of ondansetron, demonstrating a higher effectiveness in this subgroup of patients.

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Section: Discussionmentioning

confidence: 78%