2011
DOI: 10.1523/jneurosci.5564-10.2011
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Role of Extracellular Signal-Regulated Kinase in Synaptic Transmission and Plasticity of a Nociceptive Input on Capsular Central Amygdaloid Neurons in Normal and Acid-Induced Muscle Pain Mice

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Cited by 72 publications
(69 citation statements)
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“…In this study, the greatest amount of ΔFosB was seen in the CeC of both sexes. It is known that the CeC contains cocaine-amphetamine-regulated transcript (CART) which has known roles in stress and reward (Cheng et al 2011), and is seen here as well as in other studies to be highly immunoreactive for ENK (Chieng et al 2006). The increased activation of this region in a long-term setting may thus be related to the effects of alcohol on the reward systems.…”
Section: Discussionsupporting
confidence: 59%
“…In this study, the greatest amount of ΔFosB was seen in the CeC of both sexes. It is known that the CeC contains cocaine-amphetamine-regulated transcript (CART) which has known roles in stress and reward (Cheng et al 2011), and is seen here as well as in other studies to be highly immunoreactive for ENK (Chieng et al 2006). The increased activation of this region in a long-term setting may thus be related to the effects of alcohol on the reward systems.…”
Section: Discussionsupporting
confidence: 59%
“…In most studies, animal models of MTrPs are generated by the injection of acetylcholine and/or other chemical agents into the animal muscle. [4][5][6][7][8] A reliable model of MTrPs based on direct injury of animals has not yet been reported. However, injury is one of the main factors that causes MTrPs in clinical practice.…”
Section: Introductionmentioning
confidence: 99%
“…The calcium channel α 2 δ sub unit expresses primarily in the amygdala, hippocampus and neocortex through immunostaining technique [33]. A recent study has indicated that activation of postsynaptic extracellular-regulated kinase (ERK)-dependent component in the central amygdala is required to development of the postsynaptic potentiation in the acid-induced muscle pain [14]. Infusion of pregabalin into the amygdala exhibits comparable analgesic effect as that observed via oral administration by gavage (unpublished results).…”
Section: Discussionmentioning
confidence: 93%
“…Recently, acid-induced CWP animal model has shown comorbid anxiety-and depression-like behaviors [12]. This CWP animal model has been used for studying the mechanisms of peripheral and central sensitization [13][14][15]. Previous studies have shown acute effect of pregabalin on reducing hyperalgesia in the acid-induced CWP model [11].…”
Section: Introductionmentioning
confidence: 99%